Results 11 to 20 of about 2,424,188 (403)
Ferroptosis and Liver Fibrosis [PDF]
International Journal of Medical Sciences, 2021 Ferroptosis is an iron-dependent form of regulated cell death, which is characterized by a large amount of lipid peroxide accumulation and the imbalance of redox state in cells.
Q. Pan, Yi Luo, Q. Xia, K. He
semanticscholar +3 more sources
Cellular Mechanisms of Liver Fibrosis [PDF]
Frontiers in Pharmacology, 2021 The liver is a central organ in the human body, coordinating several key metabolic roles. The structure of the liver which consists of the distinctive arrangement of hepatocytes, hepatic sinusoids, the hepatic artery, portal vein and the central vein, is
P. Acharya +3 more
semanticscholar +6 more sources
Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. [PDF]
, 2015 Reactive oxygen species (ROS) produced by nicotinamide adenine dinucleotide phosphate oxidase (NOX) play a key role in liver injury and fibrosis. Previous studies demonstrated that GKT137831, a dual NOX1/4 inhibitor, attenuated liver fibrosis in mice as ...
Brenner, David A +2 more
core +9 more sources
Journal of Clinical Investigation, 2005 Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation.
Ramón, Bataller, David A, Brenner
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Cell Proliferation, 2021 Evidences demonstrate that sorafenib alleviates liver fibrosis via inhibiting HSC activation and ECM accumulation. The underlying mechanism remains unclear.
Siyu Yuan +7 more
semanticscholar +1 more source
The Turkish Journal of Gastroenterology, 2018 Liver fibrosis is a wound-healing response generated against an insult to the liver that causes liver injury. It has the potential to progress into cirrhosis, and if not prevented, it may lead to liver cancer and liver failure. The activation of hepatic stellate cells (HSCs) is the central event underlying liver fibrosis.
M Merve, Aydın, Kamil Can, Akçalı
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Gut, 2022 Objective Follistatin-like protein 1 (FSTL1) is widely recognised as a secreted glycoprotein, but its role in modulating macrophage-related inflammation during liver fibrosis has not been documented.
J. Rao +14 more
semanticscholar +1 more source
Biomarkers of liver fibrosis [PDF]
Clinical Liver Disease, 2016 Currently the only accepted method (gold standard) for the diagnosis of the fibrotic stages of chronic liver disease (CLD) is liver biopsy, to allow histological assessment. Liver biopsy is an invasive investigation associated with a range adverse events (e.g. pain, haemorrhage) limiting its serial usage in clinical practice.
Morling, Joanne R., Guha, Indra Neil
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Frontiers in Molecular Biosciences, 2020 The study aimed to clarify the role and molecular mechanism of glutamate-cysteine ligase catalytic subunit (GCLC) in modulating Hepatitis C virus (HCV)-related liver fibrosis.
Na Fu +23 more
doaj +1 more source
Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis
Frontiers in Immunology, 2022 Inflammasomes are multiprotein complexes that can sense danger signals and activate caspase-1 to mediate pro-inflammatory cytokines release and pyroptotic cell death.
Can Gan +3 more
semanticscholar +1 more source