Results 251 to 260 of about 509,312 (356)

Endoplasmic Reticulum-Targeting Natural Compounds: A Novel Frontier in Alleviating Liver Fibrosis. [PDF]

Drug Des Devel Ther
Huang C, Hu W, Qi J, Su B, Yan H, Zhu YZ.   +5 more
europepmc   +1 more source

Bile Acid Analog Intercepts Liver Fibrosis

, 2016
C. Daniel De Magalhaes Filho, Michael Downes, Ronald M. Evans   +2 more
openalex   +1 more source

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, EarlyView.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source

Present and Future Perspectives in the Treatment of Liver Fibrosis. [PDF]

Pharmaceuticals (Basel)
Cerrito L, Galasso L, Iaccarino J, Pizzi A, Termite F, Esposto G, Borriello R, Ainora ME, Gasbarrini A, Zocco MA.   +9 more
europepmc   +1 more source

Acoustic Radiation Force Impulse Elastography with APRI and FIB-4 to Identify Significant Liver Fibrosis in Chronic Hepatitis B Patients

, 2018
Cheng‐Hao Tseng, Chi‐Yang Chang, Lein‐Ray Mo, Jaw‐Town Lin, Chi‐Ming Tai, Daw‐Shyong Perng, Chih‐Wen Lin, Yao‐Chun Hsu   +7 more
openalex   +1 more source

Biodegradable Adhesive Systems for Bio‐Integrated Applications

Advanced Science, EarlyView.
Biodegradable adhesives provide temporary yet reliable adhesion while degrading into safe, non‐toxic by‐products under physiological or environmental conditions. This review summarizes recent developments in physical and chemical adhesion mechanisms—including hydrogen bonding, catechol chemistry, amine‐carboxyl coupling, and emerging diazirine and urea
Won Bae Han, Sungkeun Han, Prashant Shivaji Shewale, Hyewon Cho, Li‐Hyun Kim, Venkata Ramesh Naganaboina, Suk‐Won Hwang   +6 more
wiley   +1 more source

Stem cell therapy: a novel frontier in the treatment of liver fibrosis/cirrhosis. [PDF]

Stem Cell Res Ther
Liu Y, Li J, Su W, Wang S.
europepmc   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

AI-Assisted Drug Re-Purposing for Human Liver Fibrosis. [PDF]

Adv Sci (Weinh)
Guan Y, Cui L, Inchai J, Fang Z, Law J, Brito AAG, Pawlosky A, Gottweis J, Daryin A, Myaskovsky A, Ramakrishnan L, Palepu A, Kulkarni K, Weng WH, Cheng Z, Natarajan V, Karthikesalingam A, Rong K, Xu Y, Tu T, Peltz G.   +20 more
europepmc   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source