Results 21 to 30 of about 2,424,188 (403)
Inflammasomes in Liver Fibrosis [PDF]
Seminars in Liver Disease, 2017 AbstractCell death and inflammation are two central elements in the development of liver fibrosis. Inflammasomes are intracellular multiprotein complexes expressed in both hepatocytes and nonparenchymal cells in the liver that are key regulators of inflammation and cell fate.
Ariel E. Feldstein +3 more
openaire +3 more sources
Frontiers in Medicine, 2022 Background and aimsAccess to Hepatitis B virus (HBV) DNA testing to determine treatment eligibility is limited in low-income countries. Therefore, this study aimed to assess and validate the TREAT-B score proposed as the treatment threshold in an Asian ...
Kessarin Thanapirom +13 more
doaj +1 more source
In Vivo and In Vitro Models to Study Liver Fibrosis: Mechanisms and LimitationsSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Liver fibrosis is a common result of liver injury owing to various kinds of chronic liver diseases. A deeper understanding of the pathophysiology of liver fibrosis and identifying potential therapeutic targets of liver fibrosis is important because liver
Young-Sun Lee, Ekihiro Seki
doaj +1 more source
Cellular and Molecular Mechanisms Underlying Liver Fibrosis Regression
Cells, 2021 Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation process consisting in altered deposition of extracellular matrix.
A. Caligiuri +4 more
semanticscholar +1 more source
Reversibility of liver fibrosis [PDF]
Fibrogenesis & Tissue Repair, 2012 Liver fibrosis, and its end stage cirrhosis are a major cause of morbidity and mortality and therapeutic options are limited. However, the traditional view of liver disease as an irreversible process is obsolete and it is now evident that the development of liver fibrosis is a dynamic and potentially bidirectional process.
Pellicoro, Antonella +2 more
openaire +4 more sources
Hepatology, 2021 Cirrhosis, highly prevalent worldwide, develops after years of hepatic inflammation triggering progressive fibrosis. Currently, the main etiologies of cirrhosis are non‐alcoholic fatty liver disease and alcohol‐related liver disease, although chronic ...
P. Ginés +28 more
semanticscholar +1 more source
Current Pathobiology Reports, 2015 Hepatocyte death, inflammation, and liver fibrosis are the hallmarks of chronic liver disease. Tumor necrosis factor-α (TNFα) is an inflammatory cytokine involved in liver inflammation and sustained liver inflammation leads to liver fibrosis. TNFα exerts inflammation, proliferation, and apoptosis.
Yang, Yoon Mee, Seki, Ekihiro
openaire +5 more sources
eLife, 2020 Hepatocellular carcinoma (HCC) is a liver tumor that usually arises in patients with cirrhosis. Hepatic stellate cells are key players in the progression of HCC, as they create a fibrotic micro-environment and produce growth factors and cytokines that ...
Nataša Pavlović +6 more
doaj +1 more source
Frontiers in Medicine, 2021 An increasing percentage of people have or are at risk to develop non-alcoholic fatty liver disease (NAFLD) worldwide. NAFLD comprises different stadia going from isolated steatosis to non-alcoholic steatohepatitis (NASH).
Leen Heyens +4 more
semanticscholar +1 more source
Liver inflammation and fibrosis [PDF]
Journal of Clinical Investigation, 2017 Chronic liver inflammation leads to fibrosis and cirrhosis, which is the 12th leading cause of death in the United States. Hepatocyte steatosis is a component of metabolic syndrome and insulin resistance. Hepatic steatosis may be benign or progress to hepatocyte injury and the initiation of inflammation, which activates immune cells.
Koyama, Yukinori, Brenner, David A
openaire +5 more sources