Results 91 to 100 of about 1,127,916 (265)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Liver metastases from lung cancer

, 2015
With the improvement of techniques in liver surgery, indications to hepatic resections have been extended in the last decades to liver metastases secondary to non-colorectal, non-neuroendocrine tumors.
PINNA, ANTONIO DANIELE, RAVAIOLI, MATTEO, CESCON, MATTEO, ERCOLANI, GIORGIO, NERI, FLAVIA   +4 more
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Late-onset meningeal metastases in liposarcoma: A case report and review of the literature [PDF]

, 2006
Intracranial metastases from liposarcoma are rare and almost always preceded by the development of systemic tumour spread. We report here a case of liposarcoma with spread to the cranial nervous system 23 years after treatment of the primary tumour.
White, J., Cowie, F., Ferguson, M., Stewart, W.   +3 more
core   +1 more source

Oligometastases in pancreatic cancer (Synchronous resections of hepatic oligometastatic pancreatic cancer: Disputing a principle in a time of safe pancreatic operations in a retrospective multicenter analysis)

Annals of Gastroenterological Surgery, 2019
The aim of the present review was to analyze the current data on surgery of synchronous liver metastases in pancreatic ductal adenocarcinoma (PDAC) in curative intent.
Nina Voss, Jakob R. Izbicki, Michael F. Nentwich   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Whole-liver CT texture analysis in colorectal cancer: Does the presence of liver metastases affect the texture of the remaining liver?

, 2014
BACKGROUND: Liver metastases limit survival in colorectal cancer. Earlier detection of (occult) metastatic disease may benefit treatment and survival.
Heijnen, LA, Lambregts, DMJ, Beets, G.L., Zeng, M.S., van Ommen, W, van Nijnatten, T.J., Verhoef, Kees, Beets-Tan, RGH, Beets-Tan, R.G.H., Rao, S.X., Verhoef, C., Zeng, MS, Rao, SX, Martens, M.H., van Ommen, W., Heijnen, L.A., Martens, MH, Beets, GL, Backes, WH, Schnerr, R.S., Lambregts, D.M., van Nijnatten, TJA, Schnerr, RS, Backes, W.H.   +23 more
core   +1 more source

Late widespread skeletal metastases from myxoid liposarcoma detected by MRI only [PDF]

, 2008
Background Myxoid liposarcoma is the second most commonly occurring sub-type of liposarcomas. In contrast to other soft tissue sarcomas, it is known to have a tendency to spread toward extrapulmonary sites, such as soft tissues, retroperitoneum, and the
Lee A David, Lee Bayliss, Bayliss, L, Briggs, TW, David Lee A, O'Donnell Paul, Briggs Timothy WR, Judson, IR, Qureshi, YA, Paul O'Donnell, Judson Ian R, Ian R Judson, Yassar A Qureshi, Bayliss Lee, Timothy WR Briggs, Hanna, SA, Qureshi Yassar A, Sammy A Hanna, O'Donnell, P, Hanna Sammy A, David, LA   +20 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source