Results 81 to 90 of about 1,127,916 (265)

Deep learning CT reconstruction improves liver metastases detection

Insights into Imaging
Objectives Detection of liver metastases is crucial for guiding oncological management. Computed tomography through iterative reconstructions is widely used in this indication but has certain limitations.
Achraf Kanan, Bruno Pereira, Constance Hordonneau, Lucie Cassagnes, Eléonore Pouget, Léon Appolinaire Tianhoun, Benoît Chauveau, Benoît Magnin   +7 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Ectopic fat in liver and skeletal muscle is associated with shorter overall survival in patients with colorectal liver metastases

, 2021
Background Myosteatosis has been associated with shorter overall survival in cancer patients. The increase in ectopic fat might not be limited to skeletal muscle only and might also extend to other sites such as the liver, resulting in non-alcoholic ...
David P.J. vanDijk, Rensen, S.S.; id_orcid, Damink, S.W.M.O.; id_orcid, Zhao, J.F., David P.J. van Dijk, Vickie E. Baracos, Steven W.M. Olde Damink, Baracos, V.E., Junfang Zhao, Cornelis H.C. Dejong, Dejong, C.H.C., Kemter, K., Sander S. Rensen, Katrin Kemter, Damink, S.W.M.O., Rensen, S.S., van Dijk, D.P.J.   +16 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Predictive factors for time to recurrence, treatment and post-recurrence survival in patients with initially resected colorectal liver metastases [PDF]

, 2015
Background: Despite progress in resection for colorectal liver metastases (CLM), the majority of patients experience recurrence. We aimed to evaluate factors influencing time to recurrence (TTR), treatment and post-recurrence survival (PRS) related to ...
Løes, Inger Marie, Horn, Arild, Asgaut Viste, Inger Marie Løes, Halfdan Sorbye, Eide, Geir Egil, Angelsen, Jon-Helge, Dag Hoem, Jon-Helge Angelsen, Hoem, Dag, Arild Horn, Geir Egil Eide, Sorbye, Halfdan, Viste, Asgaut   +13 more
core   +1 more source

Use of cytoceratin-20 in revealing of colorectal cancer metastases in liver [PDF]

Саратовский научно-медицинский журнал, 2013
The aim of the study is to evaluate the possibilities of immunohistochemical revealing of colorectal cancer micro-metastases in liver and to determine their prognostic significance. Material et metods.
Fedorina Т.A., Yugina 0.V., Vozdvijenski M.0.   +2 more
doaj  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Review article liver metastases [PDF]

, 2011
Liver metastases are a very common site of distant metastases. Detection and accurate characterization of liver metastases is of importance to guide therapy.
C Koelblinger, A Ba-Ssalamah, W Schima, G Lesnik   +3 more
core   +1 more source

Platelet Volume Is Reduced In Metastasing Breast Cancer: Blood Profiles Reveal Significant Shifts

Cancer Management and Research, 2019
Ming-ming Li,1,* Chen-xi Yue,1,* Shuang Fu,1 Xin Zhang,1 Chang-Jiu Zhao,2 Rui-tao Wang1 1Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, People’s Republic of China;
Li M, Yue C, Fu S, Zhang X, Zhao CJ, Wang R   +5 more
doaj  

Liver metastases in patients with curatively treated colorectal cancer

Сибирский онкологический журнал, 2019
Background. The problem of the development of liver metastases in colorectal cancer patients previously treated with curative intent surgery remains little studied. Identification of significant factors affecting the occurrence of metachronous metastasis
R. I. Rasulov, A. A. Yudin, G. I. Songolov   +2 more
doaj   +1 more source