Results 81 to 90 of about 2,360,733 (398)

Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial [PDF]

, 2018
BACKGROUND: Although surgical resection has been considered the only curative option for colorectal liver metastases (CLM), thermal ablation has recently been suggested as an alternative curative treatment.
van Laarhoven, C. J. H. M., Stephen Morris, Twiddy, M, Croft, Julie, de Wilt, Johannes H. W., Gurusamy, Kurinchi, Damink, Steven Olde; id_orcid, C. J. H. M. van Laarhoven, Kurinchi Gurusamy, Steve Bandula, Prasad, R, Brian R. Davidson, Neil Corrigan, Gurusamy, K, Morris, Stephen, Hochhauser, Daniel, Jakowiw, Nicholas, Twiddy, Maureen, Damink, SO, Laarhoven, C.J.H.M. van, Davidson, BR, Nick Woodward, de Wilt, JHW, Corrigan, Neil, Croft, J, Jakowiw, N, Wilt, J.H.W. de, Brown, J, Hochhauser, D, Daniel Hochhauser, Woodward, N, Alison Pullan, Davidson, B.R., Maureen Twiddy, Raj Prasad, Corrigan, N, Woodward, Nick, Davidson, Brian R., Julie Croft, Bandula, S, Bandula, Steve, Steven Olde Damink, Gurusamy, K., Napp, V, de Wilt, Johannes H.W., Napp, Vicky, van Laarhoven, CJHM, Brown, Julia, Nicholas Jakowiw, Prasad, Raj, van Laarhoven, C. J.H.M., Morris, S, Johannes H. W. de Wilt, Damink, Steven Olde, Pullan, A, Pullan, Alison, Julia Brown, Vicky Napp, Morris, S.   +58 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study

BMC Cancer, 2017
Background Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (
Johannes Baur, Tjark-Ole Büntemeyer, Felix Megerle, Timo Deutschbein, Christine Spitzweg, Marcus Quinkler, Peter Nawroth, Matthias Kroiss, Christoph-Thomas Germer, Martin Fassnacht, Ulrich Steger, on behalf of the German Adrenocortical Carcinoma Study Group   +11 more
doaj   +1 more source

Recommendations for management of patients with neuroendocrine liver metastases

, 2014
Many management strategies exist for neuroendocrine liver metastases. These strategies range from surgery to ablation with various interventional radiology procedures, and include both regional and systemic therapy with diverse biological, cytotoxic, or ...
Caplin, Martyn, G. Grazi, Dik Kwekkeboom, Russell, Christopher, de Herder, W.W., Stefan Breitenstein, Catherine Klersy, Martyn Caplin, for the Working Group on Neuroendocrine Liver Metastases, Breitenstein, S, Schilsky, Richard, Irvin M. Modlin, Solcia, Enrico, Klersy, C, Russell, C, Siegler, M, Enrico Solcia, Mark Siegler, Kidd, M, Richard Schilsky, Schilsky, R, Lau, Wan-yee, Kwekkeboom, Dik, Andrea Frilling, Frilling, Andrea, Caplin, M, Salem, Riad, Wan-yee Lau, Klersy, Catherine, Davidson, B, Christopher Russell, Kidd, Mark, ), Vilgrain, Valerie, Davidson, Brian, Valerie Vilgrain, Modlin, IM, Modlin, Irvin M, Frilling, A, Solcia, E, Salem, R, Lau, WY, Vilgrain, V, Riad Salem, Siegler, Mark, Breitenstein, Stefan, Mark Kidd, Brian Davidson   +47 more
core   +1 more source

Semi-automatic 3D-volumetry of liver metastases from neuroendocrine tumors to improve combination therapy with 177Lu-DOTATOC and 90Y-DOTATOC [PDF]

, 2016
PURPOSEPatients with neuroendocrine tumors (NET) often present with disseminated liver metastases and can be treated with a number of different nuclides or nuclide combinations in peptide receptor radionuclide therapy (PRRT) depending on tumor load and ...
Tim Holland-Letz, Walter Mier, Jan Moltz, Clemens Kratochwil, Hans-Ulrich Kauczor, Peter Choyke, Uwe Haberkorn, Frederik L. Giesel, Matthaeus Cieciera   +8 more
core   +1 more source

Actual 10-year survival following hepatic resection of colorectal liver metastases: what factors preclude cure?

Surgery, 2018
Background: Hepatic resection of colorectal liver metastases is associated with long‐term survival. This study analyzes actual 10‐year survivors after resection of colorectal liver metastases, reports the observed rate of cure, and identifies factors ...
J. Creasy, E. Sadot, B. Koerkamp, J. Chou, M. Gonen, N. Kemeny, V. Balachandran, P. Kingham, R. DeMatteo, P. Allen, L. Blumgart, W. Jarnagin, M. D'Angelica   +12 more
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

The evolving role of radiation therapy as treatment for liver metastases

Journal of the National Cancer Center, 2022
Liver metastases occur commonly in many solid malignancies. With advances in systemic therapies and increased life expectancy, the role of using local therapies in oligo-metastases is rapidly increasing.
Khalid Alrabiah, Guixiang Liao, Qi Shen, Chi-Leung Chiang, Laura A. Dawson   +4 more
doaj   +1 more source

Imaging of Hepatocellular Carcinoma by Computed Tomography and Magnetic Resonance Imaging: State of the Art [PDF]

, 2009
Hepatocellular carcinoma (HCC) is a very frequent tumor worldwide. Its incidence is linked to the distribution of liver cirrhosis and viral hepatitis, which are the main risk factors for the development of HCC.
Reiser, Maximilian F., Herrmann, Karin A., Zech, Christoph J.   +2 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source