Results 61 to 70 of about 1,031,133 (262)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

GP73-dependent regulation of exosome biogenesis promotes colorectal cancer liver metastasis

Molecular Cancer
Colorectal cancer (CRC) liver metastasis is the main cause of cancer-related mortality. How liver influences intercellular communication to support CRC liver metastasis remains unknown.
Linfei Huang, Meng Wei, Huilong Li, Mingxin Yu, Luming Wan, Ruzhou Zhao, Qi Gao, Lijuan Sun, Xufeng Hou, Yunhai Mo, Qing Huang, Lan Zhen, Xiaopan Yang, Jingfei Li, Nan Wang, Chundong Zhang, Haoran Jin, Li Zhou, Yixin Xu, Haotian Lin, Xuhui Zhang, Boan Li, Yue Han, Jing Yuan, Rui Zhang, Feixiang Wu, Hui Zhong, Congwen Wei   +27 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Clinical characteristics and prognoses in pediatric neuroblastoma with bone or liver metastasis: data from the SEER 2010–2019

BMC Pediatrics
Background To investigate clinical characteristics, prognoses, and impacts of treatments on prognoses of neuroblastoma patients with bone or liver metastasis. Methods This retrospective cohort study extracted data from the Surveillance, Epidemiology, and
Xudong Zhao, Zhuofan Xu, Xiaochuan Feng
doaj   +1 more source

The role of liver microenvironment cells in colorectal cancer liver metastasis [PDF]

Waike lilun yu shijian
The liver is the most common site of metastasis in patients with colorectal cancer(CRC). The liver microenvironment is a diverse assemblage of cells, which has their own unique biological characteristics and functions, supplemented by the interaction ...
ZHAO Yiming, WU Zong, WANG Lu
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Baseline liver steatosis has no impact on liver metastases and overall survival in rectal cancer patients

BMC Cancer, 2021
Background The liver is one of the most frequent sites of metastases in rectal cancer. This study aimed to evaluate how the development of synchronous or metachronous liver metastasis and overall survival are impacted by baseline liver steatosis and ...
Giulia Besutti, Angela Damato, Francesco Venturelli, Candida Bonelli, Massimo Vicentini, Filippo Monelli, Pamela Mancuso, Guido Ligabue, Pierpaolo Pattacini, Carmine Pinto, Paolo Giorgi Rossi   +10 more
doaj   +1 more source

Impact of immunotherapy on liver metastasis

World Journal of Gastrointestinal Surgery
This editorial discusses the article “Analysis of the impact of immunotherapy efficacy and safety in patients with gastric cancer and liver metastasis” published in the latest edition of the World Journal of Gastrointestinal Surgery . Immunotherapy has achieved outstanding success in tumor treatment.
Fu, Zhuo, Wang, Ming-Wei, Liu, Ya-Hui, Jiao, Yan   +3 more
openaire   +2 more sources

Increased growth of colorectal liver metastasis following partial hepatectomy [PDF]

, 2013
Nearly 50 % of colorectal cancer (CRC) patients develop liver metastases with liver resection being the only option to cure patients. Residual micrometastases or circulating tumor cells are considered a cause of tumor relapse.
P. Krause, Krause, Petra, Koenig, S, Helms, Gunther, Monin, Malte B., Cantanhede, G., Ghadimi, BM, Ghadimi, M, Monin, M, Hosseini, Ali Seif Amir, Krause, P, M. Monin, Seif Amir Hosseini, A, Koenig, S., B. M. Ghadimi, Cantanhede, G, H. Flikweert, S. Koenig, Seif, A, Flikweert, H., Helms, Gunther,, G. Helms, G. Cantanhede, Helms, G., A. Seif Amir Hosseini, Helms, G, Lund University., Flikweert, H, König, S, Ghadimi, B. Michael   +29 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source