Results 81 to 90 of about 1,031,133 (262)

METACHRONOUS COLORECTAL LIVER METASTASIS

ABCD. Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
ABSTRACT Deaths related to colorectal cancer are generally associated with its metastases that affect the liver (50%) through the hematogenous route. Approximately 20-25% of these patients already have synchronous metastases in the liver at the time of primary tumor diagnosis.
Cássio Virgílio Cavalcante de OLIVEIRA, Rodolfo Carvalho SANTANA, Felipe José Fernandez COIMBRA, Alfred KOW, Timothy M. PAWLIK, Rene ADAM, Olivier SOUBRANE, Paulo HERMAN, Ricardo Lemos COTTA-PEREIRA   +8 more
openaire   +3 more sources

A PRELIMINARY EUROPEAN LIVER AND INTESTINE TRANSPLANT ASSOCIATION -EUROPEAN LIVER TRANSPLANT REGISTRY STUDY ON INFORMED RECIPIENT CONSENT AND EXTENDED CRITERIA LIVER DONATION

, 2013
The European Liver and Intestine Transplant Association (ELITA) and the European Liver Transplant Registry (ELTR) coordinated the distribution to European liver transplantation centers of an electronic questionnaire, developed by the first author ...
D. Giannarelli, BRUZZONE, Paolo, the European Liver, the European Liver Transplant Registry, Intestine Transplant Association, R. Adam   +5 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The liver-first approach for synchronous colorectal liver metastasis: a 5-year single-centre experience [PDF]

, 2011
BackgroundFor patients who present with synchronous colorectal carcinoma and colorectal liver metastasis (CRLM), a reversed treatment sequence in which the CRLM are resected before the primary carcinoma has been proposed (liver-first approach).
Beets, G.L., Steven W.M. Olde Damink, van Dam, R.M., Olde Damink, S., Mechteld C. de Jong, Ronald M. van Dam, Dejong, C.H.C., Cornelis H.C. Dejong, Dejong, Cornelis H.C., Olde Damink, S.; id_orcid, de Jong, Mechteld C., Geerard L. Beets, van Dam, Ronald M., Monique Maas, Beets, Geerard L., Marc H.A. Bemelmans, Maas, Monique, Bemelmans, Marc H.A., Olde Damink, Steven W.M., de Jong, M.C., Maas, M., Bemelmans, M.H.A.   +21 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Histopathological Growth Patterns Determine the Outcomes of Colorectal Cancer Liver Metastasis Following Liver Resection

Introduction: Colorectal cancer liver metastasis (CRCLM) remains a lethal diagnosis, with an overall 5-year survival rate of 5–10%. Two distinct histopathological growth patterns (HGPs) of CRCLM are known to have significantly differing rates of ...
Oran Zlotnik, Petrillo, Stephanie K., Zlotnik, Oran, Lazaris, Anthoula, Anthoula Lazaris, Stephanie K. Petrillo, Gao, Zu-Hua, Peter Metrakos, Lucyna Krzywoń, Zu-Hua Gao, Krzywoń, Lucyna, Metrakos, Peter   +11 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Evaluation of resectability after neoadjuvant chemotherapy for primary non-resectable colorectal liver metastases: A multicenter study [PDF]

, 2016
Background/Aim: The Kyushu Study Group of Clinical Cancer (KSCC) previously reported the safety and efficacy of neoadjuvant chemotherapy with mFOLFOX6 + bevacizumab for H2/H3 liver metastases of colorectal cancer.
Takatsuki, Mitsuhisa, Emi, Yasunori, Akagi, Yoshito, Oki, Eiji, Sakoda, Masahiko, Ueno, Shinichi, Ogata, Yutaka, Maehara, Yoshihiko, Tokunaga, Shoji, Uchida, Shinji, Baba, Hideo, Shirabe, Ken, Beppu, Toru, Eguchi, Susumu, Natsugoe, Shoji   +14 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source