Results 91 to 100 of about 1,031,133 (262)

Lipid Nanoparticles-Based Therapy in Liver Metastasis Management: From Tumor Cell-Directed Strategy to Liver Microenvironment-Directed Strategy

International Journal of Nanomedicine, 2023
Yuhan Wang,1 Zhenyu Yin,1 Lei Gao,1 Bin Ma,1 Jianming Shi,1 Hao Chen2 1Lanzhou University Second Hospital, Lanzhou, 730030, People’s Republic of China; 2Department of Surgical Oncology, Key Laboratory of the Digestive System Tumors of Gansu Province ...
Wang Y, Yin Z, Gao L, Ma B, Shi J, Chen H   +5 more
doaj  

Association of Enterotoxigenic Bacteroides fragilis with Immune Modulation in Colorectal Cancer Liver Metastasis

Background: Enterotoxigenic Bacteroides fragilis (ETBF) carries the bft toxin gene, which influences the host immune response and inflammatory pathways and promotes colorectal cancer (CRC).
Yu Takahashi, Yuji Miura, Shunji Takahashi, Rumiko Saito, Manabu Takamatsu, Gulanbar Amori, Kentaro Inamura, Yasuyuki Shigematsu, Mahmut Amori, Hiroaki Kanda, Kengo Takeuchi, Kenji Nishida   +11 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

A Comparative Study of Clinical and Molecular Features of Microsatellite Stable Colorectal Cancer With and Without Liver Metastases

Background: The molecular and clinical underpinnings of worse overall survival outcomes with liver metastasis of CRC are not well-defined. We therefore aimed to investigate molecular and clinical characteristics of liver metastasis of CRC in this ...
Kahramangil Baytar, Doga, Tara Magge, Syed, Masood Pasha, Aatur Singhi, Jambunathan, Bhaghyasree, Masood Pasha Syed, Sahin, Ibrahim Halil, Doga Kahramangil Baytar, Mcfarquhar, Ashley, Singhi, Aatur, Zinser Peniche, Paola, Svea Cheng, Saeed, Anwaar, Paola Zinser Peniche, Ibrahim Halil Sahin, Magge, Tara, Shuaichao Wang, Wang, Shuaichao, Anwaar Saeed, Bhaghyasree Jambunathan, Cheng, Svea, Ashley Mcfarquhar   +21 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Mechanical Force‐Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis

Advanced Science
Liver metastasis is the main cause of cancer‐related mortality. During the metastasis process, circulating carcinoma cells hardly pass through narrow capillaries, leading to nuclear deformation.
Xurui Zhang, Na Huang, Yanhua Mu, Haiyan Chen, Mengchen Zhu, Shaoying Zhang, Pengfei Liu, Hailong Zhang, Huan Deng, Keping Feng, Qi Shang, Xi Liu, Chen Zhang, Mengjiao Shi, Lan Yang, Jin Sun, Guangyao Kong, Jing Geng, Shemin Lu, Zongfang Li   +19 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Construction of a nomogram model based on biomarkers for liver metastasis in non‐small cell lung cancer

Thoracic Cancer
Background Patients with non‐small cell lung cancer (NSCLC) with liver metastasis have a poor prognosis, and there are no reliable biomarkers for predicting disease progression.
Tian Zhang, Yajuan Zhang, Yunfeng Ni, Xiaohui Jia, Yanlin Li, Ziyang Mao, Panpan Jiang, Xiaolan Fu, Min Jiao, Lili Jiang, Wenjuan Wang, Hui Guo, Ying Zan, Mengjie Liu   +13 more
doaj   +1 more source

Living donor liver transplantation for acute liver failure in pediatric patients caused by the ingestion of fireworks containing yellow phosphorus

, 2011
Yellow phosphorus is a protoplasmic toxicant that targets the liver. The ingestion of fireworks containing yellow phosphorus, either by children who accidentally consume them or by adults who are attempting suicide, often results in death due to acute ...
Işık, Burak, Selimoğlu, Mukadder Ayşe, Kayaalp, Cüneyt, Yılmaz, Sezai, Aydın, Cemalettin, Ara, Cengiz, Ateş, Mustafa, Yılmaz, Mehmet, Özgör, Dinçer, Dirican, Abuzer   +9 more
core   +1 more source