Results 101 to 110 of about 1,031,133 (262)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Development of A Computer-Aided Detection (CAD) Tool For Contrast Micro Computed Tomography Imaging In Diagnosing Liver Metastases [PDF]

, 2012
High morbidity of metastatic tumors in the liver has been observed in several different types of cancers. Liver failure from metastases is one of the primary causes of death in these patients.
Peck, Anderson Steadham
core  

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Development and validation of a nomogram to predict liver metastasis in patients with pancreatic ductal adenocarcinoma: a large cohort study

, 2019
Chaobin He,1.* Lixin Zhong,2,* Yu Zhang,3,* Zhiyuan Cai,1 Xiaojun Lin11Department of Hepatobiliary and Pancreatic Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer
He C, Zhang Y, Cai Z, Lin X, Zhong L
core  

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models [PDF]

, 2014
Melanomas are highly lethal skin tumours that are frequently treated by surgical resection. However, the efficacy of such procedures is often limited by tumour recurrence and metastasis. Caveolin-1 (CAV1) has been attributed roles as a tumour suppressor,
Bieneck, S, Muñoz, N, Quest, AF, Bennett, DC, Silva, V, Sviderskayae, Elena V., Lobos González, Lorena, Muñoz, Nicolás, Fernandez, JG, Silva, Verónica, Hossain, Mehnaz, Bennett, Dorothy C., Fernández Ruiz, Jaime Gonzalo, Quest, Andrew F. G., Burzio, V, Leyton, L, Quest, Andrew F.G., Lobos-Gonzalez, L, Bieneck, Simone, Sviderskaya, EV, Burzioc, Verónica, Aguilar Guzmán, Lorena, Hossain, M, Aguilar Guzmán, Lorena Andrea, Aguilar-Guzmán, L, Leyton Campos, Lisette   +25 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Decreased Hepatic Nerve Fiber Innervation in Patients with Liver Cirrhosis

, 2020
Background/Aims: Hepatic nerve innervation plays important roles in hepatic metabolism and hemodynamic mechanisms. We compared the distribution patterns of hepatic nerves between normal livers and two liver diseases to elucidate the effects of liver ...
유권, 김태헌, 정규원
core  

FTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cells [PDF]

, 2012
Background: Surgical procedures such as liver resection and liver transplantation are the first-line treatments for hepatocellular carcinoma (HCC) patients.
Fan Sheung Tat, Ng Kevin T. P., Shao, Y, Chang Chun Ling, Li, CX, Lo Chung Mau, Man Kwan, Ling Chang Chun, Wei Geng, Fan, ST, Ling, CC, Yuen Yuen Ma, Ma, YY, Liu Xiao Bing, Yan Shao, Xiao Bing Liu, Liu, XB, Lo, CM, Chang Xian Li, Li Chang Xian, Ma Yuen Yuen, Sheung Tat Fan, Chung Mau Lo, Geng Wei, Kevin T P Ng, Kwan Man, Shao Yan, Man, K, Geng, W, Ng, KTP   +29 more
core   +2 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source