Results 111 to 120 of about 1,031,133 (262)

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

The role of microRNAs in colorectal liver metastasis: Important participants and potential clinical significances

Tumor Biology, 2017
Colorectal cancer is one of the most common cancers in the world, and liver metastasis is the leading direct cause of cancer-related deaths in colorectal cancer.
Dongxu Wang, Jie Liu, Tingting Huo, Yaowen Tian, Lei Zhao   +4 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

SLC38A4 promotes Kupffer cell phagocytosis and suppresses tumor liver metastasis

Experimental and Molecular Medicine
Metastasis is the main cause of cancer-related death. The liver is an organ with high metastatic tropism for various malignancies. Hepatic-resident macrophage Kupffer cells are the major non-parenchymal cells in the liver that phagocytize disseminated ...
Jie Li, Yong-Da Liu, Renjie Wang, Xing-Yi Lin, Yi-Qing Zhu, Wan-Peng Lu, Yan-Fang Tang, Xing-Peng Guo, Yu-Han Ai, Ting-Ting Xu, Sen Lin, Mei Huang, Jinghan Wang, Xiao-Ting Zhu, Ji-Hang Yuan   +14 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Predictive Value of Immune Inflammation Combined with Liver Function Hematological Indicators for Metastasis of Colorectal Cancer

Zhongliu Fangzhi Yanjiu
ObjectiveTo explore the predictive value of immune inflammation combined with liver function hematological indicators for the metastasis of colorectal cancer.
Xuelei CHU, Chen AN, Lingze XI, Hongting XIE, Mingtong ZONG, Peng XUE, Shijie ZHU   +6 more
doaj   +1 more source

Exosome Released from Nuclear Met Expressing Cells Promote Liver Cancer Metastasis and Formation of Lung Premetastatic Niche

, 2017
Introduction: Our previous study have provided the first evidence about the clinical relevance of nMet in hepatocellular carcinoma (HCC). The present study was aimed to assess the role of exosomes isolated from nMet overexpressing cell line in promoting
Tey, SK, Mao, X, Yam, JWP
core  

DMBT1-liver metastasis

The liver is a major target organ for breast cancer metastasis, while the regulatory mechanism of liver colonization of breast cancer remains largely unclear.
Hu, Guohong
core   +1 more source

Abstract 3057: Gut microbiome controls liver metastasis

, 2017
Aim: The gut microbiome can modify tumor immunity and has been suggested to be involved in the development of liver cancer. However, it remains unknown how the gut microbiome controls hepatic immune responses.
Qiong Fu, Tim Greten, Chi Ma
core   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source