Results 131 to 140 of about 26,671 (292)
BLOC: Buildable and Linkable Organ on a Chip
Advanced Materials Technologies, EarlyView.We developed a “Buildable and Linkable Organ on a Chip” (BLOC) that can construct diverse microphysiological systems (MPSs). The BLOC is standardized to the same size and has one of the functions of “Culture,” “Control,” or “Analysis.” Users can freely configure various MPSs, including developing perfusion, cytotoxicity analysis, and biochemical ...
Yusuke Kimura +7 more
wiley +1 more source
hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation
Advanced ScienceLiver zonation, essential for diverse physiological functions, is lacking in existing organoid models, hindering their ability to recapitulate liver development and pathogenesis.
Yuying Zhang +13 more
doaj +1 more source
Cell Transplantation, 2019 Organ failure manifests severe symptoms affecting the whole body that may cause death. However, the number of organ donors is not enough for patients requiring transplantation worldwide. Illegal transplantation is also sometimes conducted.
Yoshiki Kuse, Hideki Taniguchi
doaj +1 more source
Hydrogel Confinement Strategies for 3D Cell Culture in Microfluidic Systems
Advanced Materials Technologies, EarlyView.Hydrogel confinement structures are key to organizing 3D cell cultures in microfluidic devices. This review classifies five structural strategies (micropillar, phaseguide, porous membrane, stepped‐height, and support‐free) and examines their trade‐offs alongside fabrication methods.
Soohyun Kim, Min Seok Lee, Sung Kyun Lee
wiley +1 more source
Advanced Materials Technologies, EarlyView.This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang +4 more
wiley +1 more source
Validating Well-Functioning Hepatic Organoids for Toxicity Evaluation
Toxics“Organoids”, three-dimensional self-organized organ-like miniature tissues, are proposed as intermediary models that bridge the gap between animal and human studies in drug development.
Seo Yoon Choi +9 more
doaj +1 more source
An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids
Advanced Materials Technologies, EarlyView.This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto +6 more
wiley +1 more source
A human liver organoid screening platform for DILI risk prediction. [PDF]
J Hepatol, 2023 Zhang CJ +9 more
europepmc +1 more source
4D cell biology: big data image analytics and lattice light-sheet imaging reveal dynamics of clathrin-mediated endocytosis in stem cell-derived intestinal organoids. [PDF]
, 2018 New methods in stem cell 3D organoid tissue culture, advanced imaging, and big data image analytics now allow tissue-scale 4D cell biology, but currently available analytical pipelines are inadequate for handing and analyzing the resulting gigabytes and ...
Betzig, Eric +6 more
core
Biohybrid Actuators in Compact Arrangement with Embedded X Electrode
Advanced Robotics Research, EarlyView.Selective control of multimuscle biohybrid actuators is crucial for achieving complex movements of biohybrid robots. In this study, embedded X electrodes are fabricated to selectively control multiple muscles, realizing the robotic finger's bidirectional movements.
Tingyu Li, Minghao Nie, Shoji Takeuchi
wiley +1 more source