Results 151 to 160 of about 26,671 (292)

Author Correction: Dialysis based-culture medium conditioning improved the generation of human induced pluripotent stem cell derived-liver organoid in a high cell density. [PDF]

Sci Rep, 2023
Torizal FG, Utami T, Lau QY, Inamura K, Nishikawa M, Sakai Y.   +5 more
europepmc   +1 more source

Engineered Living Systems With Self‐Organizing Neural Networks: From Anatomy to Behavior and Gene Expression

Advanced Science, EarlyView.
Ectodermal tissue excised from Xenopus embryos self‐organizes into a three‐dimensional mucociliary organoid. Here, we generate a neural variant, termed neurobot, by implanting neural precursor cells. Neurobots develop mature neurons, adopt distinct morphologies, exhibit more complex motility, and respond differentially to neuroactive compounds. Imaging
Haleh Fotowat, Laurie O'Neill, Léo Pio‐Lopez, Megan M. Sperry, Patrick Erickson, Tiffany Lin, Michael Levin   +6 more
wiley   +1 more source

Human liver organoid derived intra-hepatic bile duct cells support SARS-CoV-2 infection and replication. [PDF]

Sci Rep, 2022
Lui VC, Hui KP, Babu RO, Yue H, Chung PH, Tam PK, Chan MC, Wong KK.   +7 more
europepmc   +1 more source

Bioprinting of Microtissues Within Mechanically Tunable Support Baths to Engineer Anisotropic Musculoskeletal Tissues

Advanced Science, EarlyView.
This study presents a novel 4D bioprinting platform for engineering biomimetic musculoskeletal grafts. By tuning the mechanical properties of support baths, we enhance tissue fusion, collagen alignment, and cell differentiation. Using this strategy, we successfully fabricate scaled‐up, anisotropic tissues such as meniscus, articular cartilage, and ...
Francesca D. Spagnuolo, Gabriela S. Kronemberger, Daniel J. Kelly   +2 more
wiley   +1 more source

Dialysis based-culture medium conditioning improved the generation of human induced pluripotent stem cell derived-liver organoid in a high cell density. [PDF]

Sci Rep, 2022
Torizal FG, Utami T, Lau QY, Inamura K, Nishikawa M, Sakai Y.   +5 more
europepmc   +1 more source

Calcium Shock Enables Efficient and Programmable Particle Delivery for Genome Editing Applications

Advanced Science, EarlyView.
Classical transfection and transduction are inefficient, particularly with confluent cells and organoids, and lack cell type‐specific programmability. This study presents calcium shock (CaSh), a method that dramatically improves particle delivery into single cells, colonies, and organoids.
Nicole Vo, Lorena de Oñate, Maximillian Frank, Xian Hu, Sophie M. Blackburn, Dana V. Foss, Jasmine Villegas, Kunica Asija, Dirk Hockemeyer, Hongxia Fu, Raymond J. Monnat, Ross C. Wilson, Benjamin S. Freedman   +12 more
wiley   +1 more source

Electromembrane Extraction and Mass Spectrometry for Liver Organoid Drug Metabolism Studies. [PDF]

Anal Chem, 2021
Skottvoll FS, Hansen FA, Harrison S, Boger IS, Mrsa A, Restan MS, Stein M, Lundanes E, Pedersen-Bjergaard S, Aizenshtadt A, Krauss S, Sullivan G, Bogen IL, Wilson SR.   +13 more
europepmc   +1 more source

Prediction for oxaliplatin‐induced liver injury using patient‐derived liver organoids

Cancer Medicine
AbstractBackgroundLiver injury associated with oxaliplatin (L‐OHP)‐based chemotherapy can significantly impact the treatment outcomes of patients with colorectal cancer liver metastases, especially when combined with surgery. To date, no definitive biomarker that can predict the risk of liver injury has been identified.
Kumiko Tatsumi, Hiroshi Wada, Shinichiro Hasegawa, Kei Asukai, Shigenori Nagata, Tomoya Ekawa, Takashi Akazawa, Yu Mizote, Shintaro Okumura, Ryosuke Okamura, Masayuki Ohue, Kazutaka Obama, Hideaki Tahara   +12 more
openaire   +3 more sources

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Establishment and long-term expansion of adult hepatobiliary organoids co-cultured with liver endothelial cells

Heliyon
The liver has a unique ability to regenerate in response to injury or disease with hepatocytes and biliary epithelial cells (BECs) driving the regenerative response.
Hyun-Soo Roh, Da-Eun Kim, Gahee Kim, Jongsu Kim, Dengxia Fan, Hong Sook Kim, Yong-Hee Kim, Jae-Hee Lee, Byung Gak Kim, Min-Ok Ryu, Hwan Soo Kim, Kwan-Hyuck Baek, Dong Ha Bhang   +12 more
doaj   +1 more source