Results 121 to 130 of about 35,405 (287)

Integrating Bioartificial Liver Systems and Liver Organoids for Enhancing Tertiary Prevention of Liver Diseases: A Review [PDF]

علوم بهداشتی ایران
Background and Purpose: Liver diseases remain a major global health challenge, with limited therapeutic options primarily due to donor organ scarcity and inadequate preclinical models.
Tamer A. Addissouky
doaj  

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

Advanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi, Nadia Vertti‐Quintero, Julien Husson, Anne‐Laure Bulteau, Carine Nizard, Karl Pays, Sébastien Sart, Charles N. Baroud   +7 more
wiley   +1 more source

Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling

Advanced Healthcare Materials, EarlyView.
A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl, Daphne Bouwens, Johanna Abele, Aline Hans, Tanja Topic, Daniel Günther, Jitske Jansen, Rafael Kramann, Laura De Laporte   +8 more
wiley   +1 more source

Generation of Highly Functional Hepatocyte-like Organoids from Human Adipose-Derived Mesenchymal Stem Cells Cultured with Endothelial Cells

Cells
Previously, we successfully established a highly functional, three-dimensional hepatocyte-like cell (3D-HLC) model from adipose-derived mesenchymal stem cells (ADSCs) via a three-step differentiation protocol.
Shuhai Chen, Yu Saito, Yuhei Waki, Tetsuya Ikemoto, Hiroki Teraoku, Shinichiro Yamada, Yuji Morine, Mitsuo Shimada   +7 more
doaj   +1 more source

Environmental Toxin Screening Using Human-Derived 3D Bioengineered Liver and Cardiac Organoids

Frontiers in Public Health, 2018
IntroductionEnvironmental toxins, such as lead and other heavy metals, pesticides, and other compounds, represent a significant health concern within the USA and around the world.
Steven D. Forsythe, Mahesh Devarasetty, Thomas Shupe, Colin Bishop, Anthony Atala, Anthony Atala, Shay Soker, Shay Soker, Shay Soker, Shay Soker, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal   +13 more
doaj   +1 more source

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, EarlyView.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source

The vascularised chamber device significantly enhances the survival of transplanted liver organoids [PDF]

, 2023
Denis D. Shi, Evelyn Makris, Yi-Wen Gerrand, Pu‐Han Lo, George C. Yeoh, Wayne A. Morrison, Geraldine M. Mitchell, Kiryu K. Yap   +7 more
openalex   +1 more source

A Biomimetic Buffering Hydrogel Scaffold for Long‐Term Culture of Patient‐Derived Tumor Organoids

Advanced Healthcare Materials, EarlyView.
A biomimetic fibrous buffering hydrogel controls the local acidification at the tumoroid/hydrogel interface at the physiologically relevant level over 21‐day culture. The buffering effect promotes cancer cell proliferation in the tumoroids and supports the structural integrity and mechanical properties of the hydrogel scaffold over long‐term tumoroid ...
Elizaveta Gusarova, Fatemeh Ahmadi, Jennifer Cruickshank, Zheyuan Miao, David W. Cescon, Eugenia Kumacheva   +5 more
wiley   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source