Results 121 to 130 of about 23,262 (271)

Purpose‐Adaptable Reinforced 3D Hyaluronic‐Acid Based Platform to Study Pathomechanisms of the Central Nervous System

Advanced Healthcare Materials, EarlyView.
Platform system to create biofabricated 3D spinal cord tissue models: Combining high resolution PCL fiber placement, a customized, hyaluronic acid‐based hydrogel, two cell types (spinal cord neurons and astrocytes) together with three distinct laminin isoforms allow the formation of functional cell–cell network interactions.
Nicoletta Murenu, Esra Tuerker, Anna‐Lena Wiessler, Jessica Faber, Ievgenii Liashenko, Jeanette Weigelt, Jörg Tessmar, Paul D. Dalton, Sibylle Jablonka, Mateo S. Andrade Mier, Carmen Villmann, Silvia Budday, Natascha Schaefer   +12 more
wiley   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Poking Pluripotency: Nanoinjection Into Human iPSCs

Advanced Materials, EarlyView.
Nanoinjection into hiPSCs: silicon nanotubes effectively transfect human induced pluripotent stem cells (hiPSCs) with mRNA, enabled by a delayed extracellular matrix application and enhanced surface functionalization. Nanoinjection is demonstrated with several reporter mRNA, including co‐transfection of mCherry and GFP.
Jann Harberts, Vuong Thi Thanh Xuan Ho, Yuqi Yang, Yuan Jiang, Roey Elnathan, Nicolas H. Voelcker   +5 more
wiley   +1 more source

Integrating Bioartificial Liver Systems and Liver Organoids for Enhancing Tertiary Prevention of Liver Diseases: A Review [PDF]

علوم بهداشتی ایران
Background and Purpose: Liver diseases remain a major global health challenge, with limited therapeutic options primarily due to donor organ scarcity and inadequate preclinical models.
Tamer A. Addissouky
doaj  

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Parenteral nutrition emulsion inhibits CYP3A4 in an iPSC derived liver organoids testing platform.

Journal of Pediatric Gastroenterology and Nutrition - JPGN
OBJECTIVES Parenteral nutrition (PN) is used for patients of varying ages with intestinal failure to supplement calories. Premature newborns with low birth weight are at a high risk for developing PN associated liver disease (PNALD) including steatosis ...
Sean P Harrison, Saphira F Baumgarten, M. Chollet, B. Stavik, Anindita Bhattacharya, Runar Almaas, Gareth J. Sullivan   +6 more
semanticscholar   +1 more source

Advanced Mounting Technique for Improved Imaging and Analysis of Embedded Spheroids and Migrating Cells in Light Sheet Fluorescence Microscopy

Advanced Materials Technologies, EarlyView.
A novel sample holder compatible with the Zeiss Lightsheet 7 microscope improves imaging of spheroids embedded in collagen matrices. By enabling dual‐sided illumination, it enhances image quality and quantitative analysis of migrating cells. This method advances 3D light sheet microscopy for studying tumor invasion and therapeutic responses.
Masoumeh Mohamadian Namaqi, Franziska Moll, Robert Römer, Andreas Grodrian, Doris Heinrich, Karen Lemke   +5 more
wiley   +1 more source

Generation of Highly Functional Hepatocyte-like Organoids from Human Adipose-Derived Mesenchymal Stem Cells Cultured with Endothelial Cells

Cells
Previously, we successfully established a highly functional, three-dimensional hepatocyte-like cell (3D-HLC) model from adipose-derived mesenchymal stem cells (ADSCs) via a three-step differentiation protocol.
Shuhai Chen, Yu Saito, Yuhei Waki, Tetsuya Ikemoto, Hiroki Teraoku, Shinichiro Yamada, Yuji Morine, Mitsuo Shimada   +7 more
doaj   +1 more source

Environmental Toxin Screening Using Human-Derived 3D Bioengineered Liver and Cardiac Organoids

Frontiers in Public Health, 2018
IntroductionEnvironmental toxins, such as lead and other heavy metals, pesticides, and other compounds, represent a significant health concern within the USA and around the world.
Steven D. Forsythe, Mahesh Devarasetty, Thomas Shupe, Colin Bishop, Anthony Atala, Anthony Atala, Shay Soker, Shay Soker, Shay Soker, Shay Soker, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal, Aleksander Skardal   +13 more
doaj   +1 more source

Distinct toxicity of microplastics/TBBPA co-exposure to bioprinted liver organoids derived from hiPSCs of healthy and patient donors

International Journal of Bioprinting
Bioprinted tissues derived from human-induced pluripotent stem cells (hiPSCs) can provide precise information on disease mechanisms and toxicity. The detection of microplastics (MPs) in the liver tissues of patients with liver cirrhosis has raised ...
Shaojun Liang, Yixue Luo, Yijun Su, Dawei Zhang, Shi-jie Wang, Mingen Xu, Rui Yao   +6 more
semanticscholar   +1 more source