Results 41 to 50 of about 431,385 (241)

Liver X receptors regulate adrenal cholesterol balance [PDF]

Journal of Clinical Investigation, 2006
Cholesterol is the obligate precursor to adrenal steroids but is cytotoxic at high concentrations. Here, we show the role of the liver X receptors (LXRalpha and LXRbeta) in preventing accumulation of free cholesterol in mouse adrenal glands by controlling expression of genes involved in all aspects of cholesterol utilization, including the ...
Cummins, C., Volle, D.H., Zhang, Yuan, Mcdonald,, Jeffrey, Sion, Benoît, Lefrançois-Martinez, Anne-Marie, Caira, Francoise, Veyssière, Georges, Mangelsdorf, David, Lobaccaro, Jean-Marc   +9 more
openaire   +2 more sources

Alveolar Soft Part Sarcoma in Pediatric and Young Adult Patients: A Report From the Children's Oncology Group Study ARST0332

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma occurring most commonly in adolescence and young adulthood. Methods We present the clinical characteristics, treatments, and outcomes of patients with newly diagnosed ASPS enrolled on the Children's Oncology Group study ARST0332.
Jacquelyn N. Crane, Wei Xue, Amira Qumseya, Thomas Scharschmidt, Kathryn R. Tringale, Oscar Lopez Nunez, Jiaqi Hu, Donald A. Barkauskas, Rajkumar Venkatramani, Sheri L. Spunt, Aaron R. Weiss, Noah C. Federman   +11 more
wiley   +1 more source

Molecular network-based analysis of the mechanism of liver injury induced by volatile oils from Artemisiae argyi folium

BMC Complementary and Alternative Medicine, 2017
Background Volatile oils from Artemisiae argyi folium (VOAAF) is reported with hepatotoxicity, but the underlying mechanism is still unclear. Methods In the present study this molecular mechanism was explored with the Ingenuity Pathway Analysis (IPA ...
Hongjie Liu, Sha Zhan, Yan Zhang, Yan Ma, Liang Chen, Lingxiu Chen, Hanqiu Dong, Min Ma, Zhe Zhang   +8 more
doaj   +1 more source

Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2017
Objectives— The liver X receptors (LXRs) and farnesoid X receptor (FXR) have been identified in human platelets. Ligands of these receptors have been shown to have nongenomic inhibitory effects on platelet activation by platelet agonists.
Unsworth, AJ, Bye, AP, Tannetta, DS, Desborough, MJR, Kriek, N, Sage, T, Allan, HE, Crescente, M, Yaqoob, P, Warner, TD, Jones, CI, Gibbins, JM   +11 more
openaire   +5 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Liver X receptor gene polymorphisms in tuberculosis: effect on susceptibility.

PLoS ONE, 2014
ObjectivesThe Liver X receptors (LXRs), Liver X receptor A (LXRA) and Liver X receptor B (LXRB), regulate lipid metabolism and antimicrobial response. LXRs have a crucial role in the control of Mycobacterium tuberculosis (M.tb). Lacking LXRs mice is more
Min Han, Li Liang, Li-Rong Liu, Jun Yue, Yan-Lin Zhao, He-Ping Xiao   +5 more
doaj   +1 more source

Liver X receptors as regulators of metabolism

Biomolecular Concepts, 2015
Abstract The liver X receptors (LXR) are crucial regulators of metabolism. After ligand binding, they regulate gene transcription and thereby mediate changes in metabolic pathways. Modulation of LXR and their downstream targets has appeared to be a promising treatment for metabolic diseases especially atherosclerosis and cholesterol ...
Korach-André Marion, Gustafsson Jan-Åke   +1 more
openaire   +3 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis

Journal of Lipid Research, 2005
Cerebrotendinous xanthomatosis (CTX), sterol 27-hydroxylase (CYP27A1) deficiency, is associated with markedly reduced chenodeoxycholic acid (CDCA), the most powerful activating ligand for farnesoid X receptor (FXR). We investigated the effects of reduced
Akira Honda, Gerald Salen, Yasushi Matsuzaki, Ashok K. Batta, Guorong Xu, Takeshi Hirayama, G. Stephen Tint, Mikio Doy, Sarah Shefer   +8 more
doaj   +1 more source

Liver X receptors and epididymal epithelium physiology

Asian Journal of Andrology, 2007
To investigate the roles of liver X receptors (LXR) in the lipid composition and gene expression regulation in the murine caput epididymidis. LXR are nuclear receptors for oxysterols, molecules derived from cholesterol metabolism that are present in mammals as two isoforms: LXRalpha, which is more specifically expressed in lipid-metabolising tissues ...
Saez, Fabrice, Chabory, Eléonore, Cadet, Rémi, Vernet, Patrick, Baron, Silvère, Lobaccaro, Jean-Marc, Drevet, Joël   +6 more
openaire   +2 more sources