Results 51 to 60 of about 431,385 (241)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Liver X receptors

Pharmacological Research
Liver X Receptors (LXRα and LXRβ) are nuclear receptors that regulate various metabolic processes via transcriptional regulation, including lipid and cholesterol homeostasis. Recent evidence highlights the involvement of LXR activation in myelin synthesis and maintenance.
Richartz, Jule, Yam, Sammie C, Zhan, Na, Schepers, Melissa, Tiane, Assia, Mulder, Monique T, Wens, Inez, Vanmierlo, Tim   +7 more
openaire   +1 more source

Liver X Receptors and Atherosclerosis [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2014
A critical event in the development of atherosclerosis is the recruitment of macrophages to the underlying epithelial layer of blood vessel walls and the uncontrolled uptake of oxidized/modified cholesterol. Continued accumulation of oxidized/modified cholesterol by macrophages and an associated inflammatory response leads to foam cell formation and ...
Irena D, Ignatova, Ira G, Schulman
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

miR-33 inhibition attenuates the effect of liver X receptor agonist T0901317 on expression of liver X receptor alpha in mice liver

ARYA Atherosclerosis, 2017
BACKGROUND: microRNAs play pivotal roles in metabolism and other aspects of cell biology. microRNA-33 and liver X receptor (LXR) affect lipid metabolism and cholesterol trafficking.
Abbas Mohammadi, Hossein Fallah, Beydolah Shahouzehi, Hamid Najafipour   +3 more
doaj  

Fatty acid binding profile of the liver X receptor α

Journal of Lipid Research, 2017
Liver X receptor (LXR)α is a nuclear receptor that responds to oxysterols and cholesterol overload by stimulating cholesterol efflux, transport, conversion to bile acids, and excretion.
Shimpi Bedi, Genesis Victoria Hines, Valery V. Lozada-Fernandez, Camila de Jesus Piva, Alagammai Kaliappan, S.Dean Rider, Jr., Heather A. Hostetler   +6 more
doaj   +1 more source

Activation of liver X receptor/retinoid X receptor pathway ameliorates liver disease in Atp7B−/− (Wilson disease) mice [PDF]

Hepatology, 2016
Wilson disease (WD) is a hepatoneurological disorder caused by mutations in the copper‐transporter, ATP7B. Copper accumulation in the liver is a hallmark of WD. Current therapy is based on copper chelation, which decreases the manifestations of liver disease, but often worsens neurological symptoms. We demonstrate that in Atp7b−/−
James P, Hamilton, Lahari, Koganti, Abigael, Muchenditsi, Venkata S, Pendyala, David, Huso, Joseph, Hankin, Robert C, Murphy, Dominik, Huster, Uta, Merle, Christopher, Mangels, Nan, Yang, James J, Potter, Esteban, Mezey, Svetlana, Lutsenko   +13 more
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Myelin-derived lipids modulate macrophage activity by liver X receptor activation.

PLoS ONE, 2012
Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system in which macrophages and microglia play a central role.
Jeroen F J Bogie, Silke Timmermans, Vân Anh Huynh-Thu, Alexandre Irrthum, Hubert J M Smeets, Jan-Åke Gustafsson, Knut R Steffensen, Monique Mulder, Piet Stinissen, Niels Hellings, Jerome J A Hendriks   +10 more
doaj   +1 more source

Liver as a new target organ in Alzheimer’s disease: insight from cholesterol metabolism and its role in amyloid-beta clearance

Neural Regeneration Research, 2023
Alzheimer’s disease, the primary cause of dementia, is characterized by neuropathologies, such as amyloid plaques, synaptic and neuronal degeneration, and neurofibrillary tangles.
Beibei Wu, Yuqing Liu, Hongli Li, Lemei Zhu, Lingfeng Zeng, Zhen Zhang, Weijun Peng   +6 more
doaj   +1 more source