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Biological role of liver X receptors

Journal of Physiology and Pharmacology, 2008
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Targeting liver X receptors in cancer therapeutics

Nature Reviews Cancer, 2015
Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors (LXRs) are nuclear receptor family members that function in cholesterol transport, glucose metabolism and the modulation of inflammatory responses.
Chin-Yo Lin, Jan-Ake Gustafsson
exaly   +3 more sources

Targeting liver X receptors in inflammation

Expert Opinion on Therapeutic Targets, 2013
The two oxysterol receptors, 'liver X receptors (LXRs)' LXRα and LXRβ, are amongst the emerging newer drug targets within the nuclear receptor family and targeting LXRs represents novel strategies needed for prevention and treatment of diseases where current therapeutics is inadequate.This review discusses the current understanding of LXR biology with ...
Knut R, Steffensen, Tomas, Jakobsson, Jan-Åke, Gustafsson   +2 more
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A structural perspective of liver X receptors

2023
Liver X receptors α and β are members of the nuclear receptor family, which comprise a flexible N-terminal domain, a DNA binding domain, a hinge linker, and a ligand binding domain. Liver X receptors are important regulators of cholesterol and lipid homeostasis by controlling the transcription of numerous genes.
Jan-Åke, Gustafsson, Xian Chang, Li, Ji Ho, Suh, Xiaohua, Lou   +3 more
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Pregnane X Receptor Activation in Liver Perfusion

Transplantation Proceedings, 2022
Liver normothermic machine perfusion (NMP) is being adopted as a method of optimizing livers before transplantation. However, there is further potential to use the NMP model as a platform for drug delivery. Pregnane X receptor (PXR) activation upregulates CYP3A expression and has been shown to be protective against ischemia-reperfusion in rodents.
Samuel Moulding, Rodrigo Figueiredo, Avinash Sewpaul, Alistair Leitch, Lucy Bates, Matthew Wright, Colin Wilson   +6 more
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Action mechanisms of Liver X Receptors

Biochemical and Biophysical Research Communications, 2014
The two Liver X Receptors, LXRα and LXRβ, are nuclear receptors belonging to the superfamily of ligand-activated transcription factors. They share more than 78% homology in amino acid sequence, a common profile of oxysterol ligands and the same heterodimerization partner, Retinoid X Receptor. LXRs play crucial roles in several metabolic pathways: lipid
Chiara, Gabbi, Margaret, Warner, Jan-Åke, Gustafsson   +2 more
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Enolase is regulated by Liver X Receptors

Steroids, 2015
Enolase is a glycolytic enzyme known to inhibit cholesteryl ester hydrolases (CEHs). Cholesteryl ester loading of macrophages, as occurs during atherosclerosis, is accompanied by increased Enolase protein and activity. Here, we describe that J774 macrophages treated with LXR agonists exhibit reduced Enolase transcript and protein abundance.
de Boussac, Hugues, Maqdasy, Salwan, Trousson, Amalia, Zelcer, Noam, Volle, H., Lobaccaro, A., Baron, Silvere   +6 more
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The Liver X Receptor and Atherosclerosis

New England Journal of Medicine, 2007
Atherosclerosis can be prevented in mice by treating them with a ligand of the liver X receptor β, a protein expressed by macrophages.
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Liver X Receptors, Atherosclerosis and Inflammation

Current Atherosclerosis Reports, 2012
Liver X receptors (LXRs) belong to the nuclear receptor superfamily of ligand-dependent transcription factors. LXRs are activated by oxysterols, metabolites of cholesterol, and therefore act as intracellular sensors of this lipid. There are two LXR genes (α and β) that display distinct tissue/cell expression profiles.
Daryn R, Michael, Tim G, Ashlin, Melanie L, Buckley, Dipak P, Ramji   +3 more
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Liver X Receptor and Farnesoid X Receptor as Therapeutic Targets

The American Journal of Cardiology, 2007
Despite the success of existing therapies, new therapies targeted toward dyslipidemia are still needed. Liver X receptor (LXR) and farnesoid X receptor (FXR) represent 2 very different attractive targets for new therapeutic development. LXR is a nuclear receptor that primarily acts to rid cells and the body of excess cholesterol. LXR agonists have been
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