Results 261 to 270 of about 524,130 (286)
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Liver X receptor: from metabolism to cancer
Biochemical Journal, 2014Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Accumulation of cholesterol and its intermediates, such as oxysterols, lead to activation of the nuclear receptors LXRs (liver X receptors).
Nicolas, Venteclef, Pascal, Ferré
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Liver X receptors in cardiovascular and metabolic disease
Cellular and Molecular Life Sciences, 2006Liver X receptors (LXRs) alpha and beta are nuclear oxysterol receptors and metabolic sensors initially found to regulate cholesterol metabolism and lipid biosynthesis. Recent studies have elucidated the importance of LXR in the development of cardiovascular diseases and metabolic disorders.
R, Geyeregger, M, Zeyda, T M, Stulnig
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Natural modulators of liver X receptors
Journal of Integrative Medicine, 2014Nuclear receptor transcription factors are ligand-activated proteins that control various biological events from cell growth and development to lipid metabolism, and energy and glucose homeostasis. Nuclear receptors are important drug targets for metabolic diseases. Liver X receptors (LXRs) are nuclear receptor transcription factors that play essential
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Regulation of cholesterol homeostasis by liver X receptors
Clinica Chimica Acta, 2010Cellular cholesterol levels reflect a balance between uptake, efflux, and endogenous synthesis. The sterol-responsive transcription factors liver X receptors (LXRalpha and LXRbeta) help maintain cholesterol homeostasis, not only through promotion of cholesterol efflux from peripheral tissues but also through suppression of de novo synthesis and ...
Yan-Wei, Hu, Lei, Zheng, Qian, Wang
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Cardiology in Review, 2010
Liver X receptors (LXRs) are nuclear receptors that play a major role in the expression of genes which are involved in lipid metabolism. LXRs are part of the superfamily of steroid receptors that work to deliver metabolic signals on the transcriptional level to either suppress or activate target genes.
Neil, Parikh, William H, Frishman
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Liver X receptors (LXRs) are nuclear receptors that play a major role in the expression of genes which are involved in lipid metabolism. LXRs are part of the superfamily of steroid receptors that work to deliver metabolic signals on the transcriptional level to either suppress or activate target genes.
Neil, Parikh, William H, Frishman
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Xol INXS: role of the liver X and the farnesol X receptors
Current Opinion in Lipidology, 2001Cholesterol and bile acid metabolism is tightly controlled by nuclear receptors. The liver X receptor, an oxysterol-activated nuclear receptor, limits cholesterol accumulation in the body both by stimulating reverse cholesterol transport and by inhibiting intestinal cholesterol absorption.
Fayard, Elisabeth +2 more
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A Natural Product Ligand of the Oxysterol Receptor, Liver X Receptor
The Journal of Pharmacology and Experimental Therapeutics, 2003Natural products have been identified as ligands for a number of members of the nuclear hormone receptor (NHR) superfamily. Often these natural products are used as dietary supplements to treat myriad ailments ranging from perimenopausal hot flashes to hypercholesterolemia and reduced cognitive function.
Kelli S, Bramlett +14 more
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Current opinion in investigational drugs (London, England : 2000), 2005
The liver X receptors (LXRs), members of the nuclear receptor superfamily, are potential targets for a variety of diseases. While there are many opportunities for the development of LXR-based therapeutics, there are some major hurdles, such as the ability of LXRs to cause hypertriglyceridemia, as well as some species-dependent aspects of LXR-mediated ...
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The liver X receptors (LXRs), members of the nuclear receptor superfamily, are potential targets for a variety of diseases. While there are many opportunities for the development of LXR-based therapeutics, there are some major hurdles, such as the ability of LXRs to cause hypertriglyceridemia, as well as some species-dependent aspects of LXR-mediated ...
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Paeoniflorin acts as a liver X receptor agonist
Journal of Asian Natural Products Research, 2013Paeoniflorin is one of the active ingredients of Paeonia lactiflora Pall., a novel traditional herbal medicine exerting pharmacological effects including antihyperlipidemic, neuroprotective, and anti-hepatofibrosis effects. Liver X receptor (LXR) acts as a ligand-activated transcription factor to exhibit antihyperlipidemic and neuroprotective effects ...
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Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents, 2002
Xiao Hu, Deepak Lala
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Xiao Hu, Deepak Lala
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