Results 41 to 50 of about 28,050 (264)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

miR-455/GREM1 axis promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing M2 macrophage polarization

Cancer Cell International
Background Colorectal cancer is among the most common malignant tumors affecting the gastrointestinal tract. Liver metastases, a complication present in approximately 50% of colorectal cancer patients, are a considerable concern.
Shipeng Dai, Fan Xu, Xiaozhang Xu, Tian Huang, Yiming Wang, Hongyu Wang, Yucheng Xie, Lei Yue, Wenhu Zhao, Yongxiang Xia, Jian Gu, Xiaofeng Qian   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

ESRP1-mediated biogenesis of circPTPN12 inhibits hepatocellular carcinoma progression by PDLIM2/ NF-κB pathway

Molecular Cancer
Background Emerging evidence indicates the pivotal involvement of circular RNAs (circRNAs) in cancer initiation and progression. Understanding the functions and underlying mechanisms of circRNAs in tumor development holds promise for uncovering novel ...
Yang Ji, Chuangye Ni, Yanjun Shen, Zhenggang Xu, Lei Tang, Fei Yu, Lingbang Zhu, Hao Lu, Chuanyong Zhang, Shikun Yang, Xuehao Wang   +10 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Clinical and Basic Research Progress on Treg-Induced Immune Tolerance in Liver Transplantation

Frontiers in Immunology, 2021
Rejection after organ transplantation is a cause of graft failure. Effectively reducing rejection and inducing tolerance is a challenge in the field of transplantation immunology.
Xuhao Ni, Xuhao Ni, Xuhao Ni, Xuhao Ni, Qi Wang, Qi Wang, Qi Wang, Qi Wang, Jian Gu, Jian Gu, Jian Gu, Jian Gu, Ling Lu, Ling Lu, Ling Lu, Ling Lu   +15 more
doaj   +1 more source

Rescue of a Living Donor with Liver Transplantation [PDF]

American Journal of Transplantation, 2008
Postoperative liver failure is a rare complication after living donor liver resection. This is a case report of a 22-year-old healthy donor who was rescued with liver transplantation 11 days after right hemihepatectomy. Nine months later the patient is alive, and has fully recovered from his multiple organ failure.
B, Ringe, G, Xiao, D A, Sass, J, Karam, S, Shang, T P, Maroney, A E, Trebelev, S, Levison, A C, Fuchs, R, Petrucci, A, Ko, M, Gonzalez, J C, Reynolds, W C, Meyers   +13 more
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

MicroRNA-98 Inhibits Hepatic Stellate Cell Activation and Attenuates Liver Fibrosis by Regulating HLF Expression

Frontiers in Cell and Developmental Biology, 2020
Liver fibrosis is a major endpoint of patients with chronic liver diseases. The molecular mechanisms behind liver fibrosis remain largely unknown. Many studies have indicated the role of microRNA (miRNA) in hepatic tumorigenesis. But the role of miRNA in
Qi Wang, Qi Wang, Qi Wang, Qi Wang, Qi Wang, Song Wei, Song Wei, Song Wei, Song Wei, Song Wei, Haoming Zhou, Haoming Zhou, Haoming Zhou, Haoming Zhou, Lei Li, Lei Li, Lei Li, Lei Li, Shun Zhou, Shun Zhou, Shun Zhou, Shun Zhou, Chengyu Shi, Chengyu Shi, Chengyu Shi, Chengyu Shi, Yong Shi, Yong Shi, Yong Shi, Yong Shi, Jiannan Qiu, Jiannan Qiu, Jiannan Qiu, Jiannan Qiu, Ling Lu, Ling Lu, Ling Lu, Ling Lu, Ling Lu, Ling Lu, Ling Lu   +40 more
doaj   +1 more source