Results 21 to 30 of about 28,050 (264)

PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells

Nature Communications, 2022
Members of the PRDI-BF1 and RIZ homology domain (PRDM) family have been involved in the regulation of several pathological conditions, including cancer.
Qing Li, Liren Zhang, Wenhua You, Jiali Xu, Jingjing Dai, Dongxu Hua, Ruizhi Zhang, Feifan Yao, Suiqing Zhou, Wei Huang, Yongjiu Dai, Yu Zhang, Tasiken Baheti, Xiaofeng Qian, Liyong Pu, Jing Xu, Yongxiang Xia, Chuanyong Zhang, Jinhai Tang, Xuehao Wang   +19 more
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Over-Expression of GUSB Leads to Primary Resistance of Anti-PD1 Therapy in Hepatocellular Carcinoma

Frontiers in Immunology, 2022
Immunotherapy treatments, particularly immune checkpoint blockade, can result in benefits in clinical settings. But many pre-clinical and clinical studies have shown that resistance to anti-PD1 therapy frequently occurs, leading to tumor recurrence and ...
Xiangyi Kong, Zhiying Zheng, Guoxin Song, Zihao Zhang, Hanyuan Liu, Junwei Kang, Guoqiang Sun, Guangshun Sun, Tian Huang, Xiao Li, Dawei Rong, Ke Wang, Weiwei Tang, Yongxiang Xia   +13 more
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PSMC2 Regulates Cell Cycle Progression Through the p21/Cyclin D1 Pathway and Predicts a Poor Prognosis in Human Hepatocellular Carcinoma

Frontiers in Oncology, 2021
Proteasome 26S subunit ATPase 2 (PSMC2) plays a pathogenic role in various cancers. However, its function and molecular mechanism in hepatocellular carcinoma (HCC) remain unknown.
Yiwei Liu, Yiwei Liu, Yiwei Liu, Hairong Chen, Xiangcheng Li, Xiangcheng Li, Xiangcheng Li, Feng Zhang, Feng Zhang, Feng Zhang, Lianbao Kong, Lianbao Kong, Lianbao Kong, Xuehao Wang, Xuehao Wang, Xuehao Wang, Jin Bai, Jin Bai, Xiaofeng Wu, Xiaofeng Wu, Xiaofeng Wu   +20 more
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Living Donor Liver Transplantation

Chirurgia, 2017
In 50 years after the first liver transplantation, the medical world has witnessed the liver transplantation to become one of the widely recognized and leading branches of surgery. In this period, liver transplantation combined with surgical technique, patient selection, advancements in anesthesia and postoperative care and increased experience has ...
Birkan, Bozkurt, Murat, Dayangac, Yaman, Tokat   +2 more
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HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation

Signal Transduction and Targeted Therapy, 2021
N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy activation is one of the ways by which cancer cells survive hypoxia.
Qing Li, Yong Ni, Liren Zhang, Runqiu Jiang, Jing Xu, Hong Yang, Yuanchang Hu, Jiannan Qiu, Liyong Pu, Jinhai Tang, Xuehao Wang   +10 more
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Anti-IL-22 Antibody Attenuates Acute Graft-versus-Host Disease via Increasing Foxp3+ T Cell through Modulation of CD11b+ Cell Function

Journal of Immunology Research, 2018
Transfer of splenocytes isolated from B6 mice into normal B6D2F1 mice induces acute graft-versus-host disease (aGVHD), resulting in the expansion of donor cytotoxic T lymphocytes that eliminate recipient B cells. The cytokine IL-22, secreted by Th1 cells,
Jianbo Wu, Jian Gu, Shun Zhou, Hao Lu, Yunjie Lu, Ling Lu, Xuehao Wang   +6 more
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Macrophage GSK3β-deficiency inhibits the progression of hepatocellular carcinoma and enhances the sensitivity of anti-PD1 immunotherapy

Journal for ImmunoTherapy of Cancer, 2022
Background Glycogen synthase kinase 3β (GSK3β) was originally discovered to regulate glycogen synthesis and show a relationship to tumors. However, the biological functions of GSK3β in tumor-associated macrophages (TAMs) in cancers including ...
Li Liu, Jie Zhao, Jinyu Zhang, Guoqiang Sun, Yongxiang Xia, Xuehao Wang, Hanyuan Liu, Siqi Zhao, Zihao Zhang, Tian Huang, Xiangyi Kong, Weiwei Tang, Guangshun Sun, Hengsong Cao, Dawei Rong, Qinghua Ji   +15 more
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Acidic Microenvironment Regulates the Severity of Hepatic Ischemia/Reperfusion Injury by Modulating the Generation and Function of Tregs via the PI3K-mTOR Pathway

Frontiers in Immunology, 2020
Hepatic ischemia/reperfusion injury (HIRI) is a major cause of liver dysfunction and even liver failure after liver transplantation and hepatectomy. One of the critical mechanisms that lead to HIRI is an acidic microenvironment, which develops due to the
Xiaojie Gan, Xiaojie Gan, Xiaojie Gan, Xiaojie Gan, Rongsheng Zhang, Rongsheng Zhang, Rongsheng Zhang, Rongsheng Zhang, Jian Gu, Jian Gu, Jian Gu, Jian Gu, Zheng Ju, Zheng Ju, Zheng Ju, Zheng Ju, Xiao Wu, Xiao Wu, Xiao Wu, Xiao Wu, Qi Wang, Qi Wang, Qi Wang, Qi Wang, Hao Peng, Hao Peng, Hao Peng, Hao Peng, Jiannan Qiu, Jiannan Qiu, Jiannan Qiu, Jiannan Qiu, Jinren Zhou, Jinren Zhou, Jinren Zhou, Jinren Zhou, Feng Cheng, Feng Cheng, Feng Cheng, Feng Cheng, Ling Lu, Ling Lu, Ling Lu, Ling Lu   +43 more
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Epigenetics: Roles and therapeutic implications of non-coding RNA modifications in human cancers

Molecular Therapy: Nucleic Acids, 2021
As next-generation sequencing (NGS) is leaping forward, more than 160 covalent RNA modification processes have been reported, and they are widely present in every organism and overall RNA type.
Dawei Rong, Guangshun Sun, Fan Wu, Ye Cheng, Guoqiang Sun, Wei Jiang, Xiao Li, Yi Zhong, Liangliang Wu, Chuanyong Zhang, Weiwei Tang, Xuehao Wang   +11 more
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Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing

Redox Biology, 2022
Single-cell RNA-sequencing (scRNA-seq) presents better insights into cell behavior in the context of a complex tumor microenvironment by profiling single-cell populations.
Xiaopei Hao, Zhiying Zheng, Hanyuan Liu, Yao Zhang, Junwei Kang, Xiangyi Kong, Dawei Rong, Guangshun Sun, Guoqiang Sun, Li Liu, Haibo Yu, Weiwei Tang, Xuehao Wang   +12 more
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