Results 1 to 10 of about 28,050 (264)

Immune checkpoint inhibitors plus capecitabine and oxaliplatin in unresectable or advanced biliary tract cancer patients: A retrospective study

Frontiers in Oncology, 2022
ObjectiveImmune checkpoint inhibitors (ICIs) have recently been increasingly used in cancer treatment, whereas their clinical application in biliary tract cancer (BTC) patients is uncommon.
Jie Zhao, Yongzhong Guo, Wenzhou Ding, Guoyong Han, Chuanwei Jiang, Chao Yang, Yuanchang Hu, Long Zhang, Chen Wu, Ming Ni, Xiangyi Kong, Tian Huang, Chuanyong Zhang, Yongxiang Xia   +13 more
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GLIS1 intervention enhances anti-PD1 therapy for hepatocellular carcinoma by targeting SGK1-STAT3-PD1 pathway

Journal for ImmunoTherapy of Cancer, 2023
Background GLI-similar 1 (GLIS1) is one of of Krüppel-like zinc finger proteins, which are either stimulators or inhibitors of genetic transcription. Nevertheless, its effects on T cell were elusive.Methods In this study, we intend to explore the effects
Li Liu, Guoqiang Sun, Yongxiang Xia, Xuehao Wang, Hanyuan Liu, Tian Huang, Ziyi Chen, Weiwei Tang, Guangshun Sun, Hengsong Cao, Dawei Rong, Yuliang Wang, Xiaopei Hao, Zhiying Zheng, Junwei Kang   +14 more
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Targeting Immune Cells in the Tumor Microenvironment of HCC: New Opportunities and Challenges

Frontiers in Cell and Developmental Biology, 2021
Immune associated cells in the microenvironment have a significant impact on the development and progression of hepatocellular carcinoma (HCC) and have received more and more attention.
Xiaopei Hao, Guangshun Sun, Yao Zhang, Xiangyi Kong, Dawei Rong, Jinhua Song, Weiwei Tang, Xuehao Wang   +7 more
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Development and external validation of a nomogram for predicting the effect of tumor size on survival of patients with perihilar cholangiocarcinoma

BMC Cancer, 2020
Background The effect of tumor size on account of long-term survival results in perihilar cholangiocarcinoma (PCCA) patients has remained a controversial debate.
Yaodong Zhang, Zhengshan Wu, Xing Wang, Changxian Li, Jiang Chang, Wangjie Jiang, Hongwei Wang, Yirui Wang, Xiangcheng Li   +8 more
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m6A modification of circHPS5 and hepatocellular carcinoma progression through HMGA2 expression

Molecular Therapy: Nucleic Acids, 2021
N6-methyladenosine (m6A) is capable of mediating circRNA generation in carcinoma biology. Nevertheless, the posttranscriptional systems of m6A and circRNA in hepatocellular carcinoma (HCC) development are still unclear.
Dawei Rong, Fan Wu, Chen Lu, Guangshun Sun, Xiaoli Shi, Xiaoyuan Chen, Yongjiu Dai, Weizhe Zhong, Xiaopei Hao, Jinren Zhou, Yongxiang Xia, Weiwei Tang, Xuehao Wang   +12 more
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CircPAK1 promotes the progression of hepatocellular carcinoma via modulation of YAP nucleus localization by interacting with 14-3-3ζ

Journal of Experimental & Clinical Cancer Research, 2022
Background Circular RNA (circRNA), a new class of non-coding RNA, has obvious correlations with the occurrence and development of many diseases, including tumors. This study aimed to investigate the potential roles of circPAK1 in hepatocellular carcinoma
Xiaopei Hao, Yao Zhang, Xiaoli Shi, Hanyuan Liu, Zhiying Zheng, Guoyong Han, Dawei Rong, Chuanyong Zhang, Weiwei Tang, Xuehao Wang   +9 more
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Epidemiological and Clinical Characteristics of Five Rare Pathological Subtypes of Hepatocellular Carcinoma

Frontiers in Oncology, 2022
BackgroundHepatocellular carcinoma (HCC) is a highly heterogeneous tumor with several rare pathological subtypes and which is still poorly understood. This study aimed to describe the epidemiological and clinical spectrum of five rare HCC subtypes and ...
Xiaoyuan Chen, Xiaoyuan Chen, Xiaoyuan Chen, Xiaoyuan Chen, Yiwei Lu, Yiwei Lu, Yiwei Lu, Xiaoli Shi, Xiaoli Shi, Xiaoli Shi, Xiaoli Shi, Guoyong Han, Guoyong Han, Guoyong Han, Long Zhang, Long Zhang, Long Zhang, Chuangye Ni, Chuangye Ni, Chuangye Ni, Jie Zhao, Jie Zhao, Jie Zhao, Jie Zhao, Yun Gao, Yun Gao, Yun Gao, Xuehao Wang, Xuehao Wang, Xuehao Wang, Xuehao Wang   +30 more
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FER Regulated by miR-206 Promotes Hepatocellular Carcinoma Progression via NF-κB Signaling

Frontiers in Oncology, 2021
ObjectivesFeline sarcoma-related protein (FER) is known to play a critical regulatory role in several carcinomas. However, the exact biological function of FER in hepatocellular carcinoma (HCC) still needs to be investigated.
Wenzhou Ding, Wenzhou Ding, Ye Fan, Ye Fan, Wenbo Jia, Wenbo Jia, Xiongxiong Pan, Guoyong Han, Guoyong Han, Yao Zhang, Yao Zhang, Zhiqiang Chen, Zhiqiang Chen, Yiwei Lu, Yiwei Lu, Jinyi Wang, Jinyi Wang, Jindao Wu, Jindao Wu, Xuehao Wang, Xuehao Wang   +20 more
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CHSY1 promotes CD8+ T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening

Journal of Experimental & Clinical Cancer Research, 2023
Background The most common site of metastasis in colorectal cancer (CRC) is the liver and liver metastases occur in more than 50% of patients during diagnosis or treatment.
Guangshun Sun, Siqi Zhao, Zhongguo Fan, Yuliang Wang, Hanyuan Liu, Hengsong Cao, Guoqiang Sun, Tian Huang, Hongzhou Cai, Hong Pan, Dawei Rong, Yun Gao, Weiwei Tang   +12 more
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STK39 enhances the progression of Cholangiocarcinoma via PI3K/AKT pathway

iScience, 2021
Summary: Serine/threonine kinase 39 (STK39) is overexpressed in various tumor tissues and plays an essential role in tumor progression. In this study, we investigated the clinical value, as well as the potential functions and mechanisms of STK39 in ...
Xiaopei Hao, Yao Zhang, Yiwei Lu, Guoyong Han, Dawei Rong, Guoqiang Sun, Guangshun Sun, Weiwei Tang, Jindao Wu, Xuehao Wang   +9 more
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