Results 1 to 10 of about 53,126,315 (234)

LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated responses and selectively suppress Lipocalin-2 in bronchial epithelial cells [PDF]

Journal of Inflammation
Background Levels of the human cationic antimicrobial host defence peptide LL-37 are enhanced in the lungs during neutrophilic airway inflammation. LL-37 drives Th17 differentiation, and Th17 cells produce IL-17A and IL-17F which form the biologically ...
Anthony Altieri, Dylan Lloyd, Padmanie Ramotar, Anne M van der Does, Mahadevappa Hemshekhar, Neeloffer Mookherjee   +5 more
doaj   +3 more sources

LL-37 and citrullinated-LL-37 enhances oxylipins: citrullination attenuates LL-37-mediated COX-2-dependent chemokine response in human bronchial epithelial cells [PDF]

Respiratory Research
Background During airway inflammation, chemokines, oxylipins (bioactive lipids) and cationic host defence peptides (CHDP) are enhanced in the lungs. However, the interplay of these molecules in the process of airway inflammation is not fully resolved ...
Padmanie Ramotar, Mahadevappa Hemshekhar, Anthony Altieri, Anne M van der Does, Christopher D Pascoe, Neeloffer Mookherjee   +5 more
doaj   +2 more sources

Adaptive immune response to the autoantigen LL‐37 differentiates atherosclerotic cardiovascular disease phenotypes [PDF]

Clinical & Translational Immunology
Atherosclerosis is the common underlying pathology in atherosclerotic cardiovascular disease (ASCVD) phenotypes of myocardial infarction (MI), stroke or peripheral artery disease (PAD). Single immune cell profiling of atherosclerotic plaques demonstrates
Paul C. Dimayuga, Kuang‐Yuh Chyu, Jianchang Zhou, Xiaoning Zhao, Janet Wei, Bojan Cercek, Prediman K. Shah   +6 more
doaj   +2 more sources

Combined nonoxynol-9 and antimicrobial peptide LL-37 for barrier contraception [PDF]

Reproduction and Fertility
Birth control and sexually transmitted infections are global concerns. Nonoxynol-9 (N-9) is the most commonly used component in spermicides, with controversial safety and efficacy.
Murong Xu, Carol Pui Shan Chan, Luping Cong, Jacqueline Pui Wah Chung, Ellis Kin Lam Fok, David Yiu Leung Chan   +5 more
doaj   +2 more sources

LL‐37 IgG levels are associated with clinical characteristics and T follicular cell response in acute coronary syndrome in adults [PDF]

Physiological Reports
Elevated LL‐37 IgG levels are implicated in inflammatory conditions and immune complexes formed with LL‐37 potentially propagate immunothrombosis in acute coronary syndrome (ACS). The reported binding of LL‐37 to LDL may be relevant in this context given
Paul C. Dimayuga, Jianchang Zhou, Xiaoning Zhao, Kuang‐Yuh Chyu, Prediman K. Shah, Bojan Cercek   +5 more
doaj   +2 more sources

Elevated LL-37/FPR2 Axis and its Regulatory Role for Gingival Fibroblasts in Periodontitis [PDF]

International Dental Journal
Introduction and aims: LL-37, an antimicrobial peptide with dual pro-/anti-inflammatory roles, has been implicated in the pathogenesis of periodontitis, yet its specific action through its receptor Formyl peptide receptor 2 (FPR2) remains unclear.
Tingting Lin, Zhurong Cui, Yue Shen, Ruhan Yang, Weijun Yu, Shucheng Hu, Yuanjie Shi, Bin Jiang, Min Jin, Eryi Lu, Yuting Gu   +10 more
doaj   +2 more sources

LL-37 Inhibits EV71 Infection by Upregulating STAC via the EGFR-ERK Signaling Pathway [PDF]

Viruses
LL-37, a 37-amino acid human-derived antimicrobial peptide, was shown in our earlier clinical study to shorten the negative conversion time of the Omicron BA.5.1.3 variant of SARS-CoV-2.
Jiaqi Zhang, Hanlin Zhang, Yi Chen, Hanfei Liu, Shuhuang Peng, Jiwei Zhao, Zhe Luan, Yujian Zhang, Meng Dong, Wanzhu Jin, Gang Sun   +10 more
doaj   +2 more sources

The antibacterial effect of human adipose-derived stem cells on LL-37-resistant bacteria. [PDF]

PLoS ONE
Human adipose-derived stem cells (hADSCs) exhibit antibacterial properties, but their effectiveness against bacteria resistant to LL-37- a natural human antimicrobial peptide important in the immune defense- is not fully understood.
Parisa Afzal Haghjoo, Ali Mojtahedi, Malek Moien Ansar, Malek Masoud Ansar, Safieh Danesh Mobarhan   +4 more
doaj   +2 more sources

Vitamin D-inducible antimicrobial peptide LL-37 binds SARS-CoV-2 Spike and accessory proteins ORF7a and ORF8 [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundThe role of vitamin D in Coronavirus Disease 2019 (COVID-19) outcomes remains debated, but emerging evidence suggests it may enhance recovery by strengthening immune responses.
Annika Roth, Steffen Lütke, Steffen Lütke, Matthias Mörgelin, Matthias Mörgelin, Denise Meinberger, Gabriele Hermes, Gerhard Sengle, Gerhard Sengle, Gerhard Sengle, Gerhard Sengle, Gerhard Sengle, Manuel Koch, Manuel Koch, Manuel Koch, Marco Drexelius, Jan Gebauer, Ines Neundorf, Dzemal Elezagic, Mats Paulsson, Mats Paulsson, Mats Paulsson, Thomas Streichert, Andreas R. Klatt   +23 more
doaj   +2 more sources

Role of antimicrobial peptide cathelicidin in thrombosis and thromboinflammation

Frontiers in Immunology, 2023
Thrombosis is a frequent cause of cardiovascular mortality and hospitalization. Current antithrombotic strategies, however, target both thrombosis and physiological hemostasis and thereby increase bleeding risk.
Qing Zhang, Qing Zhang, Qurrat Ul Ain, Christian Schulz, Christian Schulz, Joachim Pircher, Joachim Pircher   +6 more
doaj   +1 more source