Results 141 to 150 of about 56,247,789 (275)

HA emollient does not reduce LL-37-induced inflammation.

, 2013
Experiments were performed as in Figure 7, but with immediate (t = 0) application of 1% w/w HA-containing emollient (53 kDa HA) or 1% w/w GM-1111 emollient ...
Narayanam V. Rao (356295), Lindsi McCoard (356297), William J. Rusho (356298), Glenn D. Prestwich (356300), Thomas P. Kennedy (356299), Jianxing Zhang (356291), Xiaoyu Xu (356293), Brian Argyle (356296), Gerald Krueger (356301)   +8 more
core   +1 more source

TRAIP Mediates Alcohol‐Induced Liver Injury through Regulating β‐catenin Ubiquitin Degradation via Direct Interaction

Advanced Science, EarlyView.
This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Zhan Wu, Mingjiang Liu, Lijuan Liao, Zhaohong Mo, Wenli Xu, Linfeng Mao, Yubing Chen, Qiuli Xie, Ming Yao, Shilian Chen, Stephen Tomlinson, Sebastian Mueller, Songqing He, Guandou Yuan   +13 more
wiley   +1 more source

MOESM5 of Effects of cigarette smoke on barrier function and tight junction proteins in the bronchial epithelium: protective role of cathelicidin LL-37

, 2019
Additional file 5: No protective effects of LL-37 on CSE-induced reduction in TEER disappeared at 48 h after CSE exposure. Calu-3 cells pretreated with or without 20 μg/ml LL-37 were exposed to 10% CSE. A.
Miyoko Tatsuta (7843853), Yumiko Ishii (3710503), Aimi Ogawa (7843862), Norio Yamamoto (112915), Keiko Kan-o (7843856), Akitaka Fujita (7843865), Satoru Fukuyama (7843859), Koichiro Matsumoto (7843868), Tomohiro Ogawa (205798), Yoichi Nakanishi (584819)   +9 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

LL-37, scrambled LL-37 and lysozyme induced bundle formation of Mg-F-actin at low and physiological (100 mM NaCl) ionic strength.

, 2012
(A) Kinetics of LL-37-induced bundle formation: LL-37 (2–8 µM) was added to MgF-actin (2 µM) and bundle formation was followed as an increase in light scattering at 350 nm. Presented data are representative of three independent experiments. (B) Extent of
Andras Muhlrad (116643), Gilad Bachrach (116639), Asaf Sol (116633), Edna Blotnick (116636)   +3 more
core   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Prediction of recurrent currents of tooth decay among pregnant women laboratory method evaluation of antimicrobial activity of immunity oral liquid

Кубанский научный медицинский вестник, 2015
The aim of the study was to develop a laboratory risk assessment methodology caries recurrence during pregnancy on the contents of the antimicrobial factor in innate immunity in oral fluid.
V. A. Prohodnaja, T. V. Gajvoronskaja, A. S. Lomova   +2 more
doaj  

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

Analysis of role of OMV-associated PrtV in LL-37 resistance.

, 2015
(A) PrtV protein contributes to bacterial resistance against LL-37. V. cholerae O1 El Tor strain C6706 was grown in the presence of OMVs pre-incubated with a sub-lethal concentration (25 μg/ml) of the antimicrobial peptide LL-37.
Pramod K. Rompikuntal (361308), Richard Lundmark (776716), Tanya L. Johnson (206970), Marylise Duperthuy (466225), Monika Åhlund (776715), Maria Sandkvist (206981), Jan Oscarsson (42119), Bernt Eric Uhlin (107126), Svitlana Vdovikova (625814), Sun Nyunt Wai (107124)   +9 more
core   +1 more source