Results 171 to 180 of about 56,247,789 (275)

LL-37: Biological Mechanisms and Emerging Therapeutic Applications in Intestinal Disease. [PDF]

Immun Inflamm Dis
Liu Q, Xu P, Zhang C.
europepmc   +1 more source

LL-37 and its truncated fragments modulate amyloid-β dynamics, aggregation and toxicity through hetero-oligomer and cluster formation

LL-37 and its variants with amphiphilic structure can modulate amyloid-β (Aβ) fibril formation, but the detailed mechanism behind it is still unclear. By using four different peptides (LL-37, LL-379–32, LL-3718–29, LL-3719–28), we found these peptides ...
Pereira Curia, Guadalupe (author), Mörman, Cecilia (author), Wang, Guangshun (author), Gräslund, Astrid (author), Österlund, Nicklas (author), Wang, Xue (author), Luo, Jinghui (author), Sternke-Hoffmann, Rebecca (author), L. Ilag, Leopold (author), Ilag, LL, Gräslund, Astrid,, Ilag, Leopold L.,, Wang, G, Wang, Guangshun, Wang, X, Osterlund, N, Sternke-Hoffmann, Rebecca, Luo, J, Österlund, Nicklas,, Graslund, A, Morman, C, Mörman, Cecilia, Wang, Xue, Luo, Jinghui, Pereira, Curia G, Pereira Curia, Guadalupe, Sternke-Hoffmann, R   +26 more
core   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

A Micropeptide Component of the OGDH Complex Modulates ATP Production in the TCA Cycle

Advanced Science, EarlyView.
This study identified a mitochondrial micropeptide encoded by a non‐canonical open reading frame (alt‐ORF) within the CTSB gene. This micropeptide named APPM (ATP production‐promoting micropeptide) is a novel component of the OGDHc complex in the TCA cycle. APPM localizes to the inner mitochondrial membrane and directly binds to OGDH, the E1 subunit of
Xinqiang Yin, Weiyan Qi, Lifen Lin, Huilin Zheng, Guoxiang Zhao, Quan Chen, Guoqiang Shao, Yifan Wu, Jialiang Hu, Hanmei Xu   +9 more
wiley   +1 more source

Salivary cathelicidin LL-37 as a non-invasive biomarker for oral cancer detection. [PDF]

Bioinformation
Ravichandran T, B G H, Ganesan N, K SG.
europepmc   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Inhibition of lipopolysaccharide signalling by LL-37 and repercussions for LL-37 function in the Pseudomonas-infected cystic fibrosis lung

Journal of Cystic Fibrosis, 2010
Scott, A., Weldon, S., Tunney, M., Elborn, J.S., Taggart, C.C.   +4 more
openaire   +1 more source

OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice

Advanced Science, EarlyView.
OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang, Aaron Chan, Yongyi Fan, Yanwu Wang, Pao Xue, Yingxin Zhang, Xiaodeng Zhan, Weixun Wu, Ping Yu, Daibo Chen, Junlin Fu, Yongbo Hong, Xihong Shen, Lianping Sun, Aike Zhu, Shihua Cheng, Qunen Liu, Liyong Cao   +17 more
wiley   +1 more source

A degradable hydrogel scaffold incorporating the LL-37 for gingival soft tissue regeneration. [PDF]

Regen Biomater
Mao J, Li X, Liao K, Liu L, Zheng H, Cui Y, Guo Z, Song K, Zhao J, Wu L, Zhang W, Chen J, Li W.   +12 more
europepmc   +1 more source

Loss of CYLD on Chromosome 16q Impairs Homologous Recombination and Genomic Stability Through TIRR Degradation

Advanced Science, EarlyView.
Chromosome 16q loss drives genomic instability through disruption of the CYLD–TIRR–53BP1 axis. CYLD preserves homologous recombination by stabilizing TIRR and limiting 53BP1 accumulation at DNA double‐strand breaks. CYLD deficiency redirects repair toward error‐prone non‐homologous end joining, promotes mutational burden and homologous recombination ...
Mingming Lu, Jialu Kang, Qi Ye, Zixi Wang, Lei Li, Yuzeshi Lei, Leihong Ye, Tianjie Liu, Bin Wang, Tao Liu, Shan Xu, Ke Wang, Yong Zhang, Jian Ma, Lei Li   +14 more
wiley   +1 more source