Results 191 to 200 of about 1,333,743 (274)

Comparing the genetic and serum expression of LL-37 Antimicrobial Peptide in pemphigus vulgaris and pemphigus foliaceus patients. [PDF]

An Bras Dermatol
Dhaffouli F, Elloumi N, Sellami K, Bahloul E, Tahri S, Turki H, Hachicha H, Abida O.   +7 more
europepmc   +1 more source

Interaction of Antimicrobial Peptide Ll-37 with Lipopolysaccharides [PDF]

Biophysical Journal, 2019
Michael Martynowycz, Amy Rice, Konstantin Andreev, Thatyane M. Nobre Pavinatto, Jeff Wereszczynski, David Gidalevitz   +5 more
openaire   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Evaluation of the relationship between salivary levels of Streptococcus mutans, statherin, and cathelicidin LL-37 and early childhood caries. [PDF]

BMC Oral Health
Pamuk C, Ersin N, Emingil G, Ozdemir G, Vural C, Vural C, Gül A, Çelik H, Gezgin Y.   +8 more
europepmc   +1 more source

Targeting Supramolecular Active Complexes of Nav1.7/Nav1.8 to Relieve Chronic Neuropathic Pain

Advanced Science, EarlyView.
In mice and patients with severe chronic neuropathic pain (NP), Nav1.7, Nav1.8, TrkB, and five cytoskeletal proteins form supramolecular active complexes (SMACs) with polygonal lattice structures as noxious signal amplifiers in dorsal root ganglion (DRG) neurons.
Liting Sun, Hang Xian, Yunxin Shi, Taotan Yang, Hongyan Shuai, Wenchao Hu, Siying Fei, Miao Xu, Taoyuan Yang, Ruilong Xia, Ting Wen, Fengting Zhu, Yan Fu, Yang Li, Wei Xia, Ran Qian, Yuanying Liu, Zhicheng Tian, Lamei Li, Qian Zhou, Lize Xiong, Rui Cong, Ceng Luo, Shengxi Wu, Xiafeng Shen, Xin Yu, Rou‐Gang Xie, Changgeng Peng   +27 more
wiley   +1 more source

<i>Legionella pneumophila</i>-Induced NETs Do Not Bear LL-37 Peptides. [PDF]

Microorganisms
Iliadi V, Marti S, Skeva A, Marmanis K, Tsavdaridou T, Euthymiou G, Tryfonopoulou E, Themelidis D, Xanthopoulou A, Chlichlia K, Koffa M, Konstantinidis T, Panopoulou M, Thrace Legionella Study Group.   +13 more
europepmc   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Therapeutic effect of an MRGPRX2/MRGPRB2 antagonist on LL-37-induced rosacea-like inflammation in mice. [PDF]

Inflamm Res
Chow BKC, Choi YG, Wong TK, Nawabjan SA, Li K, Kumar M.   +5 more
europepmc   +1 more source

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Antimicrobial Peptides of the Cathelicidin Family: Focus on LL-37 and Its Modifications. [PDF]

Int J Mol Sci
Voronko OE, Khotina VA, Kashirskikh DA, Lee AA, Gasanov VAO.   +4 more
europepmc   +1 more source