Results 151 to 160 of about 23,328 (215)

Bridge Nucleic Acid/DNA Gapmers as Potential Inhibitors of Bacterial Gene Expression by Multiple Antisense Mechanisms: An In Vitro Study. [PDF]

Molecules
Magaña AJ, Phan K, Lopez JA, Ramirez MS, Tolmasky ME.   +4 more
europepmc   +1 more source

Xeno-nucleic acids support formation of Ag(I)-mediated duplexes and silver nanoclusters. [PDF]

Nucleic Acids Res
Guha R, Bethur E, Chim N, Gupta MK, Lin IH, Taylor RE, Chaput JC, Copp SM.   +7 more
europepmc   +1 more source

CoSMIC: A hybrid approach for large-scale, high-resolution microbial profiling of novel niches. [PDF]

PLoS One
Knafo M, Rezenman S, Idan T, Elgart M, Dagan S, Zavaro V, Reich Z, Kapon R, Sade D, Shental N.   +9 more
europepmc   +1 more source

Doxorubicin compromises blood-brain barrier integrity by suppressing annexin A1 expression. [PDF]

Open Life Sci
Hu N, Liu W, Jiang S, Yin Y.
europepmc   +1 more source

Synthesis, Biological Activity, and Molecular Dynamics Simulations of LNA-Charge Neutral Linkages for Enhanced Splice-Switching Antisense Oligonucleotides. [PDF]

Angew Chem Int Ed Engl
Kennett A, Lie L, Flerin M, Kurt BZ, Baker YR, Hill AC, Ramesh A, Wood MJA, Dhara D, El-Sagheer AH, Duarte F, Brown T.   +11 more
europepmc   +1 more source

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Nuclease Stability of LNA Oligonucleotides and LNA-DNA Chimeras

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Troels Koch
exaly   +3 more sources

Aptamers as a model for functional evaluation of LNA and 2′-amino LNA

Bioorganic and Medicinal Chemistry Letters, 2009
The affinity change upon incorporation of LNA and 2'-amino-LNA monomers into an avidin binding DNA aptamer is described. The kinetic profile of selected modified-aptamer was obtained by surface plasmon resonance experiments and compared with the profile of the parent unmodified DNA aptamer.
Frank J Hernández, Jesper Wengel, Birte Vester   +2 more
exaly   +3 more sources

Improvement of a streptavidin-binding aptamer by LNA- and α-l-LNA-substitutions

Bioorganic and Medicinal Chemistry Letters, 2014
Forty modified versions of a streptavidin-binding aptamer each containing single or multiple LNA or α-l-LNA-substitutions were synthesized and their dissociation constants determined by surface plasmon resonance experiments. Both full-length and truncated versions of the aptamer were studied and compared with the unmodified DNA aptamers.
Jesper Wengel, Birte Vester, Lykke H Hansen   +2 more
exaly   +4 more sources

LNA and α-L-LNA: Towards Therapeutic Applications

Nucleosides, Nucleotides and Nucleic Acids, 2003
LNA and alpha-L-LNA are promising candidates for the development of efficient oligonucleotide-based therapeutic agents. Here, we report dose-dependent inhibition of HIV-1 Tat-dependent trans activation by a 12-mer chimeric alpha-L-LNA/DNA oligomer. This oligomer exhibits a dose-dependency similar to that of the corresponding 12-mer chimeric LNA/2'-O-Me-
Wengel, J., Vester, B., Lundberg, L.B., Douthwaite, S., Sørensen, M.D., Babu, B.R., Gait, M.J., Arzumanov, A., Petersen, M., Nielsen, J.T.   +9 more
openaire   +3 more sources