Results 161 to 170 of about 23,328 (215)
Some of the next articles are maybe not open access.
The first analogues of LNA (Locked Nucleic Acids): Phosphorothioate-LNA and 2′-thio-LNA
Bioorganic & Medicinal Chemistry Letters, 1998LNA (Locked Nucleic Acids, 1, X = O, Y = O) is a novel oligonucleotide analogue capable of recognizing complementary DNA and RNA with unprecedented thermal affinities. Synthesis of the first chemically modified LNA analogues is reported. A 9-mer phosphorothioate-LNA containing three LNA thymine monomers (1, X = O, Y = S, Base = thymin-1-yl) and 9-mer ...
Kumar, Ravindra +5 more
openaire +3 more sources
LNA characterization methodologies
International Journal of Circuit Theory and Applications, 2016SummaryJoint characterization of low‐noise amplifiers regarding stochastic and deterministic parameters based on output power measurement for a set of known input termination impedances is considered. As an advantage of this method, both noise parameters and the input impedance can be obtained for narrow and broad band applications without special ...
Bernhard Lehmeyer +2 more
openaire +1 more source
Structural Characterization of LNA and α-L-LNA Hybridized to RNA
Nucleosides, Nucleotides and Nucleic Acids, 2003LNA and alpha-L-LNA are promising candidates for the development of efficient oligonucleotide-based therapeutic agents. Here, we present a short overview of the structural results we have obtained for LNA:RNA and alpha-L-LNA:RNA hybrids. Specifically, we have shown that LNA acts as an A-type mimic, while alpha-L-LNA acts as a B-type mimic when built ...
Petersen, M.; id_orcid 0000-0002-0997-7657 +4 more
openaire +3 more sources
In Vitro Incorporation of LNA Nucleotides
Nucleosides, Nucleotides & Nucleic Acids, 2007An LNA modified nucleoside triphosphate 1 was synthesized in order to investigate its potential to act as substrate for DNA strand synthesis by polymerases. Primer extension assays for the incorporation experiments revealed that Phusion High Fidelity DNA polymerase is an efficient enzyme for incorporation of the LNA nucleotide and for extending strand ...
Veedu, R.N., Vester, B., Wengel, J.
openaire +5 more sources
STRUCTURAL STUDIES ON LNA QUADRUPLEXES
Nucleosides, Nucleotides & Nucleic Acids, 2005LNAs (locked nucleic acids) are new DNA analogues with higher binding affinities toward nucleic acids than the canonical counterparts mainly due to the characteristic conformational restriction arising from the 2'-O, 4'-C methylene bridge. In light of the promising therapeutic applications and considering the advantageous characteristics of LNAs, such ...
RANDAZZO, ANTONIO +5 more
openaire +3 more sources
Analog Integrated Circuits and Signal Processing, 2001
Three LNAs at 2 GHz frequency range have been implemented in a SiGe Bipolar process targeted for a universal mobile telecommunications system. The LNAs are operating in two gain modes and they include a power-down mode. Both on-wafer and packaged LNAs were measured.
Ryynänen Jussi +2 more
openaire +1 more source
Three LNAs at 2 GHz frequency range have been implemented in a SiGe Bipolar process targeted for a universal mobile telecommunications system. The LNAs are operating in two gain modes and they include a power-down mode. Both on-wafer and packaged LNAs were measured.
Ryynänen Jussi +2 more
openaire +1 more source
Structural Characterization of LNA and α‐L‐LNA Hybridized to RNA
ChemInform, 2004AbstractFor Abstract see ChemInform Abstract in Full Text.
Michael Petersen +4 more
openaire +1 more source
Chemical Communications, 1999
Remarkably strong binding affinities towards complementary single stranded DNA and RNA were obtained for 10- and 14-mer LNAs (locked nucleic acids) containing diastereoisomeric β-D-ribo, β-D-xylo or α-L-ribo configured LNA thymine monomers; a possible relevance of these results in relation to nucleic acid evolution is discussed.
Rajwanshi, Vivek Kumar +3 more
openaire +2 more sources
Remarkably strong binding affinities towards complementary single stranded DNA and RNA were obtained for 10- and 14-mer LNAs (locked nucleic acids) containing diastereoisomeric β-D-ribo, β-D-xylo or α-L-ribo configured LNA thymine monomers; a possible relevance of these results in relation to nucleic acid evolution is discussed.
Rajwanshi, Vivek Kumar +3 more
openaire +2 more sources
2007 14th IEEE International Conference on Electronics, Circuits and Systems, 2007
A monolithic low-noise-amplifier operating in the 60 GHz band is presented. The circuit has been designed utilizing an advanced 0.25 mum SiGe BiCMOS technology, featuring npn transistors with fT and fmax ap 200 GHz. A two stage cascode architecture has been chosen for the implementation.
Van-Hoang Do +2 more
openaire +1 more source
A monolithic low-noise-amplifier operating in the 60 GHz band is presented. The circuit has been designed utilizing an advanced 0.25 mum SiGe BiCMOS technology, featuring npn transistors with fT and fmax ap 200 GHz. A two stage cascode architecture has been chosen for the implementation.
Van-Hoang Do +2 more
openaire +1 more source
LNA noise parameter measurement
2015 European Conference on Circuit Theory and Design (ECCTD), 2015Joint measurement of stochastic parameters of a low noise amplifier (LNA), based on output power measurement for input termination impedances is considered. As an advantage of this method the noise parameters can be determined in a quick way for narrow and broad band applications without special equipment.
Bernhard Lehmeyer +2 more
openaire +1 more source