Results 161 to 170 of about 117,740 (287)

Piezo1‐Mediated Mechanotransduction: Orchestrating the Dynamic Response of Podocytes and Parietal Epithelial Cells to Mechanical Stress

open access: yesActa Physiologica, Volume 242, Issue 3, March 2026.
ABSTRACT Aim The glomerulus is a specialized microvascular unit that filters plasma through the coordinated function of podocytes and parietal epithelial cells (PECs). From this perspective, the glomerulus functions like a living hydrogeological filtration system.
Maria Elena Melica   +3 more
wiley   +1 more source

Implementing Genomic Medicine in Primary Care: A Convergent Mixed Method Case Study

open access: yesJournal of Evaluation in Clinical Practice, Volume 32, Issue 2, March 2026.
ABSTRACT Purpose Despite the growing interest in implementing genomic medicine into primary care, numerous barriers persist. Herein we present formative work conducted at three primary care clinics to identify barriers to implementation as part of a state‐funded genomic medicine initiative.
Emory W. Heffernan   +10 more
wiley   +1 more source

Precision RNAi in Tomato Using Synthetic Trans‐Acting Small Interfering RNAs Derived From Minimal Precursors

open access: yesPlant Biotechnology Journal, Volume 24, Issue 3, Page 1269-1284, March 2026.
ABSTRACT RNA interference (RNAi) is a highly conserved gene silencing mechanism regulating gene expression at transcriptional and post‐transcriptional levels in plants. Synthetic trans‐acting small interfering RNAs (syn‐tasiRNAs) have emerged as powerful tools for highly specific and efficient gene silencing.
Ariel H. Tomassi   +8 more
wiley   +1 more source

LNA modification of single-stranded DNA oligonucleotides allows subtle gene modification in mismatch-repair-proficient cells [PDF]

open access: bronze, 2016
Thomas W van Ravesteyn   +6 more
openalex   +1 more source

Downregulation of microRNA‐494 drives mitochondrial biogenesis and function in trained muscle

open access: yesExperimental Physiology, Volume 111, Issue 3, Page 1093-1108, 1 March 2026.
Abstract MicroRNAs (miRNAs) are key regulators of cellular processes, including mitochondrial function and energy metabolism. This study explores the regulation of miR‐494 in skeletal muscle and circulation, investigating its response to exercise training and an acute exercise bout, its association with metabolic disorders, and the effects of ...
Natália Pálešová   +10 more
wiley   +1 more source

Locked nucleic acid (LNA) based PCR approach for the diagnosis and screening of spinal muscular atrophy [PDF]

open access: diamond
Gökçe Güllü Amuran   +4 more
openalex   +1 more source

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