Results 1 to 10 of about 167,789 (348)

LncRNA-mediated regulation of cell signaling in cancer

Oncogene, 2017
To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play
Wan-Xin Peng, Pratirodh Koirala, Y. Mo
semanticscholar   +1 more source

Progress in understanding the role of lncRNA in programmed cell death

Cell Death Discovery, 2021
Long non-coding RNAs (lncRNAs) are transcripts longer than 200 nucleotides but not translated into proteins. LncRNAs regulate gene expressions at multiple levels, such as chromatin, transcription, and post-transcription.
N. Jiang, Xiaoyu Zhang, Xuejun Gu, Xiaozhuang Li, L. Shang   +4 more
semanticscholar   +1 more source

LncRNA GATA3-AS1 promotes the proliferation and migration of breast cancer cells and the mechanisms underlying its action [PDF]

Yixue xinzhi zazhi, 2022
Objective Long non-coding RNA (LncRNA) is closely related to the occurrence and development of various tumors. This study aimed to investigate the biological role and mechanism of LncRNA GATA3-AS1 in breast cancer progression.Methods The expression level
Qi JIANG, Yi-Qing XI, Lei WEI
doaj   +1 more source

Lnc2Cancer 3.0: an updated resource for experimentally supported lncRNA/circRNA cancer associations and web tools based on RNA-seq and scRNA-seq data

Nucleic Acids Res., 2020
An updated Lnc2Cancer 3.0 (http://www.bio-bigdata.net/lnc2cancer or http://bio-bigdata.hrbmu.edu.cn/lnc2cancer) database, which includes comprehensive data on experimentally supported long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) associated
Yue Gao, Shipeng Shang, Shuang Guo, Xin Li, Hanxiao Zhou, Hongjia Liu, Yue Sun, Junwei Wang, Peng Wang, Hui Zhi, Xia Li, Shangwei Ning, Yunpeng Zhang   +12 more
semanticscholar   +1 more source

LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy

Nature Cell Biology, 2021
Major histocompatibility complex-I (MHC-I) presents tumour antigens to CD8+ T cells and triggers anti-tumour immunity. Humans may have 30,000–60,000 long noncoding RNAs (lncRNAs).
Gaopeng Li, Ilona Kryczek, Jutaek Nam, Xiong Li, Shasha Li, Jing Li, Shuang Wei, Sara Grove, Linda Vatan, Jiajia Zhou, W. Du, Heng Lin, Ton Wang, C. Subramanian, J. Moon, M. Cieslik, Mark S. Cohen, W. Zou   +17 more
semanticscholar   +1 more source

LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis

Molecular Cancer, 2020
Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are aberrantly expressed in various cancers. However, the functional roles of lncRNAs in breast cancer remain largely unknown.
Yiran Liang, Xiaojing Song, Yaming Li, Bing Chen, Wenjing Zhao, Lijuan Wang, Hanwen Zhang, Y. Liu, Dianwen Han, Ning Zhang, T. Ma, Yajie Wang, F. Ye, Dan Luo, Xiaoyan Li, Qifeng Yang   +15 more
semanticscholar   +1 more source

lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/β-catenin signaling

Molecular Cancer, 2020
MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination are well established, but the involvement of long noncoding RNAs (lncRNAs) in Twist1-mediated signaling remains largely unknown.
Jinchang Pan, S. Fang, Haihua Tian, Chengwei Zhou, X. Zhao, H. Tian, Jinxian He, W. Shen, Xiaodan Meng, Xiaofeng Jin, Zhaohui Gong   +10 more
semanticscholar   +1 more source

Long Noncoding RNA (lncRNA)-Mediated Competing Endogenous RNA Networks Provide Novel Potential Biomarkers and Therapeutic Targets for Colorectal Cancer

International Journal of Molecular Sciences, 2019
Colorectal cancer (CRC) is the third most common cancer and has a high metastasis and reoccurrence rate. Long noncoding RNAs (lncRNAs) play an important role in CRC growth and metastasis.
Liye Wang, Kwang Bog Cho, Yan Li, Gabriel Tao, Zuoxu Xie, Bin Guo   +5 more
semanticscholar   +1 more source

The pan-cancer lncRNA MILIP links c-Myc to p53 repression

Molecular & Cellular Oncology, 2021
We have recently identified the MYC proto-oncogene, bHLH transcription factor (MYC, best known as c-Myc)-responsive pan-cancer lncRNA c-Myc-Inducible Long noncoding RNA Inactivating P53 (MILIP) as an oncogenic driver.
Yu Chen Feng, Xiao Hong Zhao, Liu Teng, Rick F. Thorne, Lei Jin, Xu Dong Zhang   +5 more
doaj   +1 more source

Epithelial-mesenchymal transition-related genes in coronary artery disease

Open Medicine, 2022
Epithelial-mesenchymal transition (EMT) is critical in the development of coronary artery disease (CAD). However, landscapes of EMT-related genes have not been fully established in CAD.
Xu Xiang, Zou Renchao, Liu Xiaoyong, Liu Jia, Su Qianqian   +4 more
doaj   +1 more source