Results 21 to 30 of about 64,353 (185)

LncRNA expression profile in human malignant embryonic rhabdomyosarcoma cell line infected with Coxsackie virus group B type 5 [PDF]

Jichu yixue yu linchuang, 2022
Objective To explore the molecular mechanism of the interaction between Coxsackie virus group B type 5 (CVB5) and the host, The long non-coding RNA(lncRNA) expression profile in human malignant embryonic rhabdomyosarcoma cell line (RD) infected by CVB5 ...
TENG Pei-ying, LI Jing, SHI Yu-lu, YANG Fan, OU Xia, CHEN Wei
doaj   +1 more source

SGII: Systematic Identification of Essential lncRNAs in Mouse and Human Genome With lncRNA-Protein-Protein Heterogeneous Interaction Network

Frontiers in Genetics, 2022
Long noncoding RNAs (lncRNAs) play important roles in a variety of biological processes. Knocking out or knocking down some lncRNA genes can lead to death or infertility. These lncRNAs are called essential lncRNAs.
Xiao-Hong Xin, Ying-Ying Zhang, Chu-Qiao Gao, Hui Min, Likun Wang, Pu-Feng Du   +5 more
doaj   +1 more source

Function of lncRNAs and approaches to lncRNA-protein interactions [PDF]

Science China Life Sciences, 2013
Long non-coding RNAs (lncRNAs), which represent a new frontier in molecular biology, play important roles in regulating gene expression at epigenetic, transcriptional and post-transcriptional levels. More and more lncRNAs have been found to play important roles in normal cell physiological activities, and participate in the development of varieties of ...
Zhu, JuanJuan, Fu, HanJiang, Wu, YongGe, Zheng, XiaoFei   +3 more
openaire   +2 more sources

Long noncoding RNA HOTAIR interacts with Y-Box Protein-1 (YBX1) to regulate cell proliferation

Life Science Alliance, 2021
The authors determined that HOTAIR specifically bind to YBX1 and promote its nuclear translocation, and then regulating cell proliferation by stimulating the PI3K/Akt and ERK/RSK signaling pathways. HOTAIR is a long noncoding RNA (lncRNA) which serves as
Siting Li, Qian Xiong, Minghai Chen, Bing Wang, Xue Yang, Mingkun Yang, Qiang Wang, Zongqiang Cui, Feng Ge   +8 more
doaj   +1 more source

The Challenges and Opportunities of lncRNAs in Ovarian Cancer Research and Clinical Use [PDF]

, 2020
[Abstract] Ovarian cancer is one of the most lethal gynecological malignancies worldwide because it tends to be detected late, when the disease has already spread, and prognosis is poor.
Barreiro-Alonso, Aida, Cerdán, María Esperanza, Lamas, Mónica, Quindós-Varela, María, Rodríguez-Belmonte, Esther, Salamini-Montemurri, Martín, Vizoso-Vázquez, Ángel   +6 more
core   +1 more source

LPI-CSFFR: Combining Serial Fusion with Feature Reuse for Predicting LncRNA-Protein Interactions [PDF]

Computational Biology and Chemistry, 2022
<p>Long non-coding RNAs (LncRNAs) play important roles in a series of life activities, and they function primarily with proteins. The wet experimental-based methods in lncRNA-protein interactions (lncRPIs) study are time-consuming. Therefore, in this study, we propose a reliable computational-based method called LPI-CSFFR using sequences ...
Xiaoqian, Huang, Yi, Shi, Jing, Yan, Wenyan, Qu, Xiaoyi, Li, Jianjun, Tan   +5 more
openaire   +2 more sources

Probing lncRNA–Protein Interactions: Data Repositories, Models, and Algorithms

Frontiers in Genetics, 2020
Identifying lncRNA-protein interactions (LPIs) is vital to understanding various key biological processes. Wet experiments found a few LPIs, but experimental methods are costly and time-consuming. Therefore, computational methods are increasingly exploited to capture LPI candidates.
Lihong Peng, Fuxing Liu, Jialiang Yang, Xiaojun Liu, Yajie Meng, Xiaojun Deng, Cheng Peng, Geng Tian, Liqian Zhou   +8 more
openaire   +3 more sources

Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma. [PDF]

, 2017
Long non-coding RNAs (lncRNAs) have a critical role in cancer initiation and progression, and thus may mediate oncogenic or tumor suppressing effects, as well as be a new class of cancer therapeutic targets. We performed high-throughput sequencing of RNA
Ai, B, Bai, X-F, Cao, H-H, Feng, C-C, He, J-Z, Huang, G-W, Koeffler, HP, Lei, F, Li, C-Q, Li, E-M, Li, M, Li, S, Li, X, Li, X-C, Liao, L-D, Lin, D-C, Liu, Y-J, Shen, J-H, Tang, Z-D, Wang, L-D, Wang, M-R, Wang, Q-Y, Wang, S-H, Wu, B-L, Wu, J-Y, Wu, Z-Y, Xu, L-Y, Xu, Y-J, Xue, Y-J, Zhang, J, Zhao, J-M, Zheng, C-P, Zhu, Y   +32 more
core   +1 more source

Revealing protein-lncRNA interaction [PDF]

, 2015
Long non-coding RNAs (lncRNAs) are associated to a plethora of cellular functions, most of which require the interaction with one or more RNA-binding proteins (RBPs); similarly, RBPs are often able to bind a large number of different RNAs.
Colantoni, A, Ferrè, F, Helmer-Citterich, M   +2 more
core   +1 more source

The Landscape of Long Non-Coding RNA Dysregulation and Clinical Relevance in Muscle Invasive Bladder Urothelial Carcinoma. [PDF]

, 2019
Bladder cancer is one of the most common cancers in the United States, but few advancements in treatment options have occurred in the past few decades.
Chang, Eric Y, Chu, Megan, High, Rachel A, Li, Wei Tse, Ongkeko, Weg M, Shen, Haotian, Wang-Rodriguez, Jessica, Wong, Lindsay M   +7 more
core   +1 more source