Results 31 to 40 of about 33,666 (150)

Assessing recent selection and functionality at long noncoding RNA loci in the mouse genome [PDF]

, 2015
This work was supported by the Biotechnology and Biological Sciences Research Council and The Wellcome Trust. A.N. was supported by the Swiss National Science Foundation (Grant: PZ00P3_142636). H.K. was supported by the European Research Council Starting
Ness, Rob W, Keightley, Peter D, Kaessmann, H., Keightley, P. D., Halligan, D. L., Ness, R. W., Wiberg, R.A., Wiberg, Ralf Axel Wilhelm, Halligan, Daniel L, Ness, R.W., Keightley, P.D., Keightley, Peter D., Kaessmann, Henrik, Wiberg, R. A., Wiberg, R Axel W, Ness, Rob W., Necsulea, A., Halligan, D.L., Halligan, Daniel L., Necsulea, Anamaria   +19 more
core   +1 more source

Long Non-coding RNA X-Inactive Specific Transcript Mediates Cell Proliferation and Intrusion by Modulating the miR-497/Bcl-w Axis in Extranodal Natural Killer/T-cell Lymphoma

Frontiers in Cell and Developmental Biology, 2020
The present study was directed toward laying new findings for Extranodal natural killer/T-cell lymphoma (ENKL)-oriented therapy with a focus on long non-coding RNA (lncRNA)–microRNAs (miRNAs)–mRNA interaction.
Qinhua Liu, Ruonan Ran, Zhengsheng Wu, Xiaodan Li, Qingshu Zeng, Ruixiang Xia, Yalei Wang   +6 more
doaj   +1 more source

The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome [PDF]

, 2013
Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. We investigated the localization mechanisms of the Xist lncRNA during X-chromosome inactivation (XCI), a paradigm of ...
Engreitz, Jesse M., Kadri, Sabah, Lander, Eric S., Goren, Alon, Pandya-Jones, Amy, McDonel, Patrick, Surka, Christine, Engreitz, Jesse Michael, Plath, Kathrin, Guttman, Mitchell, Lander, Eric Steven, Shishkin, Alexander, Xing, Jeffrey, Sirokman, Klara   +13 more
core   +1 more source

Potential roles of lncRNA-XIST/miRNAs/mRNAs in human cancer cells

, 2023
Long non-coding RNAs (lncRNAs) are non-coding RNAs that contain more than 200 nucleotides but do not code for proteins. In tumorigenesis, lncRNAs can have both oncogenic and tumor-suppressive properties.
Masoodi, T., Dari, M. A. G., Nasrolahi, A., Ghaedrahmati, F., Uddin, S., Azizidoost, S., Radoszkiewicz, K., Farzaneh, M., Sheykhi-Sabzehpoush, M., Najafi, S., Khoshnam, S. E.   +10 more
core   +1 more source

The role of lncRNAs and XIST in oral cancer

Frontiers in Cell and Developmental Biology, 2022
Long non-coding RNA (lncRNA) plays a significant role in the pathogenesis of many human malignant tumors, including oral cancer. LncRNA can act as a gene regulator in a variety of cancers.
Huimin Liu, Dongxu Wang, Shaoning Kan, Ming Hao, Lu Chang, Pengxu Lu, Yangyang Liu, Ye Jin, Weiwei Liu, Weiwei Liu   +9 more
doaj   +1 more source

SViswanathanLab/XIST-Males-Scripts: v1.0.0

, 2022
Somatic XIST activation and features of X chromosome inactivation in male human cancers [Sadagopan et al.
as1000, Mingkee Achom, inasim1998
core   +1 more source

Long non-coding XIST raises methylation of TIMP-3 promoter to regulate collagen degradation in osteoarthritic chondrocytes after tibial plateau fracture

Arthritis Research & Therapy, 2019
Background Hypermethylation of gene promoters has been regarded as an epigenetic regulator for gene inactivation in the development of several diseases.
Hongwei Chen, Shengdi Yang, Ruyi Shao
doaj   +1 more source

LncRNA XIST promoted the stability of TLR9 mRNA in a FUS-dependent manner to facilitate aerobic glycolysis and proliferation in Th17/CD4+T cells

Linchuang shenzangbing zazhi, 2022
ObjectiveTo explore the expression and function of lncRNA XIST in Th17 cells in IgA nephropathy （IgAN） and examine the regulation of lncRNA XIST on TLR9 mRNA expression.MethodsCD4+T cells were isolated from peripheral blood mononuclear cells （PBMCs） and ...
Wu Yan-ping, Ma Xiao, Han Si-ping, Wang Xiao-qin   +3 more
doaj  

LncRNA XIST restrains the activation of Müller cells and inflammation in diabetic retinopathy via stabilizing SIRT1

, 2021
Background Recent studies have provided strong evidence that lncRNAs play a functional regulatory role in diabetic retinopathy (DR). The purpose of this study was to investigate the effect of long non-coding RNA (lncRNA) X-inactive specific transcript ...
Chengwei Chen, Zhenguo Chen, Jiayu Zhang, Liang Wu, Sifang Zhang, Jiawei Chen   +5 more
core   +2 more sources

Association of XIST/miRNA155/Gab2/TAK1 cascade with the pathogenesis of anti-phospholipid syndrome and its effect on cell adhesion molecules and inflammatory mediators

Scientific Reports, 2023
Anti-phospholipid syndrome (APS) is an autoimmune disease characterized by thrombosis and miscarriage events. Still, the molecular mechanisms underlying APS, which predisposes to a wide spectrum of complications, are being explored. Seventy patients with
Mai A. Abd-Elmawla, Yumn A. Elsabagh, Nora M. Aborehab   +2 more
doaj   +1 more source