Results 21 to 30 of about 33,666 (150)

LncRNA-XIST Competitively Binds to MicroRNA-532-5p to Regulate PTEN Expression, Exacerbating Cerebral Ischemia-Reperfusion Injury. [PDF]

Adv Biol (Weinh)
Cerebral ischemia‐reperfusion injury (CIRI) is a severe neurological condition. LncRNA‐XIST is closely associated with CIRI; however, its underlying mechanism remains unclear.
Lu X, Chen L, Qian L, Zhang X, Wang Y, Yu B.   +5 more
europepmc   +2 more sources

Interfering lncRNA XIST inhibits the growth of salivary adenoid cystic carcinoma cells and improves cisplatin sensitivity by up-regulating miR-429 [PDF]

Xin yixue, 2022
ObjectiveTo investigate the regulatory effect and mechanism of lncRNA XIST on salivary adenoid cystic carcinoma （SACC） cell growth and cisplatin （DDP） chemosensitivity.
Zhang Xuan, Ma Licheng, Sun Longxiao, Zhang Lei
doaj   +1 more source

LncRNA XIST promotes liver cancer progression by acting as a molecular sponge of miR-200b-3p to regulate ZEB1/2 expression

Journal of International Medical Research, 2021
Objective To evaluate the predictive value of long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) for survival, and determine the involvement of miRNA(miR)-200b-3p and zinc finger E-box-binding homeobox (ZEB) 1/2 in the pro-tumor effect of
Lili Liu, Hua Jiang, Hongming Pan, Xiuming Zhu   +3 more
doaj   +1 more source

LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinoma

Molecular Medicine, 2021
Background Long non-coding RNA (lncRNA) XIST has been implicated in the progression of a variety of tumor diseases. The purpose of this study was to explore the molecular role of lncRNA XIST in human hepatitis B virus (HBV)-related hepatocellular ...
Jiancheng Wang, Gang Yin, Hu Bian, Jiangli Yang, Pengcheng Zhou, Kai Yan, Cheng Liu, Pei Chen, Jun Zhu, Zhi Li, Tongqing Xue   +10 more
doaj   +1 more source

lncRNA Xist regulates sevoflurane-induced social and emotional impairment by modulating miR-98-5p/EDEM1 signaling axis in neonatal mice

Molecular Therapy: Nucleic Acids, 2021
Long non-coding RNA (lncRNA) X-inactive specific transcript (Xist) is involved in apoptosis and inflammatory injury. This study aimed to assess the role of lncRNA Xist in sevoflurane-induced social and emotional impairment and neuronal apoptosis in ...
Lili Xu, Qi Xu, Shaobing Dai, Cuicui Jiao, Yingying Tang, Jiaqian Xie, Hui Wu, Xinzhong Chen   +7 more
doaj   +1 more source

LncRNA XIST facilitates hypertrophy of ligamentum flavum by activating VEGFA-mediated autophagy through sponging miR-302b-3p. [PDF]

Biol Direct, 2023
Background Increasing evidences have shown that long non-coding RNAs (lncRNAs) display crucial regulatory roles in the occurrence and development of numerous diseases.
Cao Y, Li J, Qiu S, Ni S, Duan Y.
europepmc   +2 more sources

Long non-coding RNA XIST: a novel oncogene in multiple cancers

Molecular Medicine, 2021
Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions as an oncogene. XIST is involved in multiple
Jun Yang, Manlong Qi, Xiang Fei, Xia Wang, Kefeng Wang   +4 more
doaj   +1 more source

Mbd2 contributes to DNA methylation-directed repression of the Xist gene [PDF]

, 2007
Transcription of the Xist gene triggers X chromosome inactivation in cis and is therefore silenced on the X chromosome that remains active. DNA methylation contributes to this silencing, but the mechanism is unknown.
Hermann, Andrea, Prokhortchouk, Anna, Adie, Karen, Hendrich, Brian, Barr, Helen, Tsai, Hsin-Hao, Berger, Jennifer, Bird, Adrian; id_orcid   +7 more
core   +1 more source

DataSheet_1_Effect of LncRNA XIST on Immune Cells of Primary Biliary Cholangitis.pdf

, 2022
ObjectivePrimary biliary cholangitis (PBC) is an autoimmune disease with significant gender difference. X chromosome inactivation (XCI) plays important roles in susceptibility to diseases between genders.
Bin Liu (5899), Qixuan Liu (2445208), Chunhui She (12194288), Patrick S. C. Leung (11271105), Yuan Yao (31223), Yifei Yang (585215), Bo Zang (12194291)   +6 more
core   +1 more source

Silencing of HuR Inhibits Osteosarcoma Cell Epithelial-Mesenchymal Transition via AGO2 in Association With Long Non-Coding RNA XIST

Frontiers in Oncology, 2021
BackgroundOsteosarcoma (OS) is a highly malignant and aggressive bone tumor. This study was performed to explore the mechanisms of HuR (human antigen R) in the progression of OS.MethodsHuR expression levels in OS tissues and cells were detected by ...
Yongming Liu, Yuan Zhang, Jinxue Zhang, Jingchang Ma, Xuexue Xu, Yuling Wang, Ziqing Zhou, Dongxu Jiang, Shen Shen, Yong Ding, Yong Zhou, Ran Zhuang, Ran Zhuang   +12 more
doaj   +1 more source