Biological Function of Long Non-coding RNA (LncRNA) Xist [PDF]
Frontiers in Cell and Developmental Biology, 2021 Long non-coding RNAs (lncRNAs) regulate gene expression in a variety of ways at epigenetic, chromatin remodeling, transcriptional, and translational levels. Accumulating evidence suggests that lncRNA X-inactive specific transcript (lncRNA Xist) serves as
Chuanyang Liu, Xin-Yuan Qiu, Lu Min
exaly +4 more sources
LncRNA xist regulates sepsis associated neuroinflammation in the periventricular white matter of CLP rats by miR-122-5p/PKCη Axis [PDF]
Frontiers in Immunology, 2023 BackgroundNeuroinflammation is a common feature of many neurological diseases, and remains crucial for disease progression and prognosis. Activation of microglia and astrocytes can lead to neuroinflammation.
Huifang Wang +13 more
doaj +2 more sources
Effect of LncRNA XIST on Immune Cells of Primary Biliary Cholangitis [PDF]
Frontiers in Immunology, 2022 ObjectivePrimary biliary cholangitis (PBC) is an autoimmune disease with significant gender difference. X chromosome inactivation (XCI) plays important roles in susceptibility to diseases between genders.
Chunhui She +6 more
doaj +2 more sources
Long noncoding RNA X‐inactive specific transcript (lncRNA XIST) inhibits hepatic insulin resistance by competitively binding microRNA‐182‐5p [PDF]
Immunity, Inflammation and Disease, 2023 Background What is highlighted in this study refers to the role and molecular mechanism of long noncoding RNA (lncRNA) X‐inactive specific transcript (XIST) in cells with insulin resistance (IR).
Guoqing Zhong +5 more
doaj +2 more sources
Role of lncRNA Xist-miR-124-CCL2 axis in HIV Tat-mediated microglial activation and neuroinflammation [PDF]
Frontiers in ImmunologyIntroductionHIV proteins, such as the Transactivator of transcription (Tat), mediate neuroinflammation in the central nervous system by promoting the release of pro-inflammatory cytokines and chemokines.
Palsamy Periyasamy +4 more
doaj +2 more sources
Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke [PDF]
Molecular Therapy: Nucleic Acids, 2021 The aim of this study was to investigate the function and regulatory mechanism of long non-coding RNA (lncRNA) X-inactive-specific transcript (XIST) in cerebral ischemic stroke (CIS).
Cong Wang +8 more
doaj +2 more sources
LncRNA XIST promotes bladder cancer progression by modulating miR-129-5p/TNFSF10 axis [PDF]
Discover OncologyBackground The differential expression, biological function, and ceRNA regulatory mechanism of lncRNA XIST in bladder cancer (BC) were investigated, and its clinical values for the early diagnosis of bladder cancer patients were elucidated.
Yu-Lin Kong +4 more
doaj +2 more sources
SETD7-mediated epigenetic regulation of LncRNA XIST promotes trophoblast pyroptosis: a study in preeclampsia mouse and cell models [PDF]
Biology DirectBackground Pre-eclampsia (PE) is a severe pregnancy-specific hypertensive disorder that poses significant risks to both maternal and fetal health. This study seeks to elucidate the mechanism by which SETD7 regulates trophoblast cell pyroptosis in PE ...
Xiaolan Zhao +3 more
doaj +2 more sources
A Boolean Model of the Proliferative Role of the lncRNA XIST in Non-Small Cell Lung Cancer Cells [PDF]
Biology, 2022 The long non-coding RNA X inactivate-specific transcript (lncRNA XIST) has been verified as an oncogenic gene in non-small cell lung cancer (NSCLC) whose regulatory role is largely unknown.
Shantanu Gupta +3 more
doaj +2 more sources
Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signaling [PDF]
Heliyon, 2023 Acute myeloid leukemia (AML) is a life-threatening aggressive malignancy of the bone marrow and has posed a great challenge to the clinic, due to a lack of fully understanding of the molecular mechanism. Histone deacetylase 1 (HDAC1) has been reported to
Chao Wen +5 more
doaj +2 more sources