Results 61 to 70 of about 33,666 (150)

Molecular and genomic advances in breast cancer: A comprehensive review of predictive and therapeutic innovations

Precision Medical Sciences, Volume 15, Issue 3, Page 164-175, September 2026.
Breast cancer subtypes, estrogen receptor‐positive (ER+), HER2‐enriched, and TNBC, are defined by genomic and epigenetic signatures. Multi‐omics profiling, immunotherapy, liquid biopsy, and AI‐driven radiogenomics enable precision medicine. Tools like Oncotype DX and PAM50 support personalized care.
Samina Malik, Arif Malik, Shahzad Ahmad, Hassan Mohsin, Shazia Iqbal   +4 more
wiley   +1 more source

Long Non-Coding RNA XIST Promotes Wilms Tumor Progression Through the miR-194-5p/YAP Axis

Cancer Management and Research, 2021
Xingyue He,1 Xin Luo,2 Junjun Dong,1 Xing Deng,1 Feng Liu,1,2 Guanghui Wei1,2 1Department of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key ...
He X, Luo X, Dong J, Deng X, Liu F, Wei G   +5 more
doaj  

XIST Is a Key Modulator Associated With the Adhesome Network

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
CRISPRi‐mediated knockdown of XIST in OVCAR3 ovarian cancer cells alters adhesome gene expression, supporting a functional connection between XIST and cell adhesion programs. Building on this finding, transcriptomic analyses of GTEx and TCGA datasets reveal that XIST is strongly coordinated with the adhesome network across normal tissues, whereas this ...
Dongning Chen, Nolan Origer, Sha Sun, Timothy L. Downing   +3 more
wiley   +1 more source

Systematic Discovery of Xist RNA Binding Proteins [PDF]

, 2015
SummaryNoncoding RNAs (ncRNAs) function with associated proteins to effect complex structural and regulatory outcomes. To reveal the composition and dynamics of specific noncoding RNA-protein complexes (RNPs) in vivo, we developed comprehensive ...
Flynn, Ryan A., Chu, Ci, Calabrese, J. Mauro, Zhang, Qiangfeng Cliff, Heard, Edith, Chang, Howard Y., da Rocha, Simão Teixeira, Bharadwaj, Maheetha, Magnuson, Terry   +8 more
core   +1 more source

XIST lost induces ovarian cancer stem cells to acquire taxol resistance via a KMT2C-dependent way

Cancer Cell International, 2020
Background/aims The expression levels of long non-coding RNA XIST are significantly associated with paclitaxel (Pac) sensitivity in ovarian cancer, but the mechanism of action remains unclear.
Ruili Huang, Lijuan Zhu, Yali Zhang
doaj   +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, Volume 81, Issue 9, Page 3039-3070, September 2026.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter, Ian M. Adcock, Cristina Benito‐Villalvilla, Rodolfo Bianchini, Leif Bjermer, Gaetano Caramori, Luigi Cari, Kian Fan Chung, Zuzana Diamant, Ibon Eguiluz‐Gracia, Edward F. Knol, Milos Jesenak, Francesca Levi‐Schaffer, Giuseppe Nocentini, Liam O'Mahony, Oscar Palomares, Frank Redegeld, Milena Sokolowska, Betty Van Esch, Marco Zurlo, Cristiana Stellato   +20 more
wiley   +1 more source

Extensive remodelling of XIST regulatory networks during primate evolution

, 2023
Unravelling how gene regulatory networks are remodelled during evolution is crucial to understand how species adapt to environmental changes. We addressed this question for X-chromosome inactivation, a process essential to female development that is ...
Dong, Michael, Castel, Gaël, Alfeghaly, Charbel, Heard, Edith, Rognard, Cloé, Loda, Agnese, Rougeulle, Claire, Savatier, Pierre, Cazottes, Emmanuel, Aksoy, Irène, Villacorta, Laura, Morey, Céline   +11 more
core   +1 more source

Long Noncoding RNAs in Aortic Dissection: Mechanistic Roles and Therapeutic Potential

AGING MEDICINE, Volume 9, Issue 4, Page 416-425, August 2026.
Aortic dissection (AD) involves vascular inflammation, VSMC dysfunction, and ECM degradation. LncRNAs regulate AD progression via ceRNA networks, with great potential as diagnostic biomarkers and therapeutic targets, while further clinical validation is needed.
Chao Chang, Yongrong Lan, Zhenhua Wu, Jie Geng, Zhigang Guo, Qingliang Chen   +5 more
wiley   +1 more source

Functional dissection of the Xist lncRNA conserved sequences in X-chromosome inactivation

, 2022
Tese de mestrado, Biologia Molecular e Genética, Universidade de Lisboa, Faculdade de Ciências, 2019Introduction: Due to the discrepancy in the number of X chromosomes between the sexes in many animal species, dosage compensation mechanisms have evolved ...
Gil, Cláudia Raquel Estopa
core  

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3 [PDF]

, 2014
Many long non-coding RNAs (lncRNAs) affect gene expression, but the mechanisms by which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is required for transcriptional silencing of one X chromosome during development in
Eric S. Lander, McHugh, Colleen A, Christina Tran, Surka, Christine F., Julia Su, Christine F. Surka, Lander, Eric S, Moradian, Annie, Burghard, Christina, Amy Chow, Su, Julia, Guttman, Mitchell, Lander, Eric Steven, Lander, Eric, Tran, Christina, Mitchell Guttman, Michael J. Sweredoski, Sweredoski, Michael J., Annie Moradian, Christina Burghard, Kathrin Plath, Sonja Hess, Lander, Eric S., Pandya-Jones, Amy, Blanco, Mario, McDonel, Patrick, Chow, Amy, Colleen A. McHugh, Shishkin, Alexander A, Sweredoski, Michael J, Plath, Kathrin, Alexander A. Shishkin, Surka, Christine F, McHugh, Colleen A., Shishkin, Alexander A., Amy Pandya-Jones, Mario Blanco, Chen, Chun-Kan, Hess, Sonja, Chun-Kan Chen, Patrick McDonel   +40 more
core   +1 more source