Results 101 to 110 of about 31,278 (264)

LncRNA–Protein Interactions: A Key to Deciphering LncRNA Mechanisms

Biomolecules
Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators in a multitude of biological processes. However, their functional basis, particularly structure-based functional characteristics, remains elusive. lncRNAs exert their influence primarily through intricate interactions with various cellular components.
Zuoneng Wang, Muhammad Aftab, Zigang Dong, Yanan Jiang, Kangdong Liu   +4 more
openaire   +3 more sources

LncRNAs in pancreatic cancer

Oncotarget, 2016
Pancreatic cancer (PC) is one of the most common causes of cancer-related death. The underlying mechanism of PC is not completely understood at present. Studies in recent years have demonstrated that long non-coding RNAs (lncRNAs) have multiple biological functions in cell growth, differentiation and proliferation.
Huang, Xiaoyi, Zhi, Xiaosong, Gao, Yisha, Ta, Na, Jiang, Hui, Zheng, Jianming   +5 more
openaire   +3 more sources

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton

Advanced Science, EarlyView.
Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang, Jie Dai, Ting Zhao, Shengjun Zhao, Hongyu Wu, Jiaying Pan, Yupeng Hao, Ke Nie, Li Yu, Yumeng Zhu, Xiangyi Zhao, Kai Huang, Mengke Zhang, Yongyan Zhao, Yaping Jiang, Siyuan Wang, Yiling Pan, Yubing Chen, Yilai Lin, Wanghong Shi, Yayuan Deng, Jin Han, Jie Li, Xuan Long, Junbin Wang, Zhiyuan Zhang, Zegang Han, Zhanfeng Si, Lei Ju, Jun Li, Tianzhen Zhang, Ji Zhou, Xueying Guan   +32 more
wiley   +1 more source

Revealing protein–lncRNA interaction [PDF]

Briefings in Bioinformatics, 2015
Long non-coding RNAs (lncRNAs) are associated to a plethora of cellular functions, most of which require the interaction with one or more RNA-binding proteins (RBPs); similarly, RBPs are often able to bind a large number of different RNAs. The currently available knowledge is already drawing an intricate network of interactions, whose deregulation is ...
Fabrizio Ferrè, Alessio Colantoni, Manuela Helmer-Citterich   +2 more
openaire   +4 more sources

Long Non-Coding RNAs in Brown Adipose Tissue

Diabetes, Metabolic Syndrome and Obesity, 2020
Songjia Lai,1,* Kun Du,1,* Yu Shi,1 Cao Li,1 Guoze Wang,1,2 Shenqiang Hu,1 Xianbo Jia,1 Jie Wang,1 Shiyi Chen1 1Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130 ...
Lai S, Du K, Shi Y, Li C, Wang G, Hu S, Jia X, Wang J, Chen S   +8 more
doaj  

Molecular Interactions of lncRNAs: Cellular Fate Determination and Tissue Regeneration [PDF]

Journal of Cell and Molecular Research, 2015
LncRNAs (long non-coding RNAs) are responsible to control the degradation process, RNA stability, orchestration, inhibition, transcription and histone modification etc.
Monireh Bahrami, Muhammad Irfan-Maqsood
doaj   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

Lipid−lncRNA Crossroads: An Overview of Interactions Between Lipids and lncRNA

Cells
Long non-coding RNAs (lncRNAs) interact with a variety of biomolecules, including DNA, mRNAs, microRNA, and proteins, to regulate various cellular processes. Recently, their interactions with lipids have gained increasing attention as an emerging research area.
Andrea Bayona-Hernandez, Ana Miladinović, Ludovica Antiga, Pavel Hozak, Martin Sztacho, Enrique Castano   +5 more
openaire   +3 more sources

Identification of key pathways and molecular players potentially involved in endometrial cancer metastasis through integrated bioinformatics analyses [PDF]

BioImpacts
Introduction: Endometrial cancer (EC) is a particularly frequent gynecological cancer, and metastasis is the leading cause of death in patients with EC.
Maryam Rezazadeh, Shahla Danaei-Mehrabad, Nahideh Afshar Zakariya, Fatemeh Kazemi, Marziyeh Sadat Moslehian, Amin Tamadon, Reza Shirazi, Mahdi Mahdipour, Parvin Hakimi   +8 more
doaj   +1 more source