Results 91 to 100 of about 76,795 (267)

Transcriptomic Analysis of Trigeminal Ganglion and Spinal Trigeminal Nucleus Caudalis in Mice with Inflammatory Temporomandibular Joint Pain

Journal of Pain Research, 2022
Tieli Dong,1,* Haichao Si,1,2,* Zhisong Li,1 Qian Bai,1 Feng Tao3 1Department of Anesthesiology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Anesthesiology, Nanyang Central ...
Dong T, Si H, Li Z, Bai Q, Tao F
doaj  

Identification and Functional Characterization of PI3K/Akt/mTOR Pathway-Related lncRNAs in Lung Adenocarcinoma: A Retrospective Study [PDF]

Cell Journal
Objective: This paper aimed to investigate the PI3K/Akt/mTOR signal-pathway regulator factor-related lncRNAsignatures (PAM-SRFLncSigs), associated with regulators of the indicated signaling pathway in patients with lungadenocarcinoma (LUAD) undergoing ...
Jiaqi Zhong, Ying Kong, Ruming Li, Minghan Feng, Liming Li, Xiao Zhu, Lianzhou Chen   +6 more
doaj   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Identification of Potential Prognostic Long Non-Coding RNA Biomarkers for Predicting Recurrence in Patients with Cervical Cancer

Cancer Management and Research, 2020
Yan Zhang,1 Xing Zhang,1 Haixia Zhu,2 Yang Liu,3 Jian Cao,3 Dake Li,3 Bo Ding,4 Wenjing Yan,1 Hua Jin,2,* Shizhi Wang1,* 1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing,
Zhang Y, Zhang X, Zhu H, Liu Y, Cao J, Li D, Ding B, Yan W, Jin H, Wang S   +9 more
doaj  

Long Noncoding RNAs in Aortic Dissection: Mechanistic Roles and Therapeutic Potential

AGING MEDICINE, EarlyView.
Aortic dissection (AD) involves vascular inflammation, VSMC dysfunction, and ECM degradation. LncRNAs regulate AD progression via ceRNA networks, with great potential as diagnostic biomarkers and therapeutic targets, while further clinical validation is needed.
Chao Chang, Yongrong Lan, Zhenhua Wu, Jie Geng, Zhigang Guo, Qingliang Chen   +5 more
wiley   +1 more source

Long Non-Coding RNA and mRNA Profiles in the Spinal Cord of Rats with Resiniferatoxin-Induced Neuropathic Pain

Journal of Pain Research, 2022
Caihua Wu,1 Yongmin Liu,2 Kexing Wan,2 Yuye Lan,2 Min Jia,3 Lixue Lin,4 Shan Gao,1 Ke Chen,1 Jinmei Yang,1 Hui-Lin Pan,5 Man Li,2 Hongrong Mao1 1Department of Acupuncture, Wuhan First Hospital, Wuhan, Hubei Province, 430030, People’s Republic of China ...
Wu C, Liu Y, Wan K, Lan Y, Jia M, Lin L, Gao S, Chen K, Yang J, Pan HL, Li M, Mao H   +11 more
doaj  

lncRNA-ACOD1: GOT2 has got a lncRNA cofactor

Non-coding RNA Investigation, 2018
In spite of the limited information encoded in viral genomes, viruses can infect and replicate in complex organisms. Evolution has selected viruses able to use cellular factors to achieve viral entry, viral protein expression, and viral replication, packaging and release.
Marina Barriocanal, Puri Fortes
openaire   +1 more source

Genome‐wide network analysis identifies the lncRNA‐92467/miR‐205‐5p/PTPRM/CAMs axis in a rat model of hypoxic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of hypoxic pulmonary hypertension (HPH) remains unclear. In this study, we explored its key regulatory mechanisms using animal models, RNA sequencing, and cellular assays. We found that lncRNA‐92467 functions as a ceRNA, binding miR‐205‐5p, and thereby upregulating PTPRM, inhibiting abnormal proliferation and migration of endothelial ...
Yan‐Ying Shen, Yi‐Bing Chen, Xin Li, Xiang Xu, Ge Guo, Han‐Lu Li, Yong‐Ming Yao, Chun‐Lei Liu   +7 more
wiley   +1 more source

Biophysical Characterization and Proteomic Analysis of Small Extracellular Vesicles Derived From Different Neural Cell Lines

Advanced NanoBiomed Research, EarlyView.
This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey E. Collins‐Praino, Andrew Care, Yuling Wang   +4 more
wiley   +1 more source