Results 71 to 80 of about 31,278 (264)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
New Insights into the Roles of Yes-Associated Protein (YAP1) in Colorectal Cancer Development and Progression [PDF]
Iranian Journal of Colorectal Research, 2019 Yes-associated protein (YAP1), the downstream effector of the Hippo pathway, plays important roles in the regulation of tissue reconstruction,stem cell proliferation, and development of different cancers.
Fariba Dehghanian +3 more
doaj
Targeting long non-coding RNAs as new modulators in anti-EGFR resistance mechanisms [PDF]
BioImpactsEpidermal growth factor receptor (EGFR) is a cell surface protein that plays a vital role in regulating cell growth and division. However, certain tumors, such as colorectal cancer (CRC), can exhibit an overexpression of EGFR, resulting in uncontrolled ...
Mostafa Akbarzadeh-Khiavi +2 more
doaj +1 more source
Cellular and molecular basis of thyroid autoimmunity
European Thyroid Journal, 2023 Autoimmune thyroid disease (AITD) is the most common human autoimmune disease. The two major clinical manifestations of AITD are Graves’ disease and Hashimoto’s thyroiditis (HT).
Joanna Bogusławska +3 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
LncRNAs in ocular neovascularizations
International Journal of Ophthalmology, 2019 The prevalence of eye diseases worldwide is dramatically increasing and represents a major concern in underdeveloped and developed regions. Ocular diseases, previously associated with a higher depression risk, also impose a substantial economic burden on affected families, thus early detection and/or accurate treatment in order to avoid and prevent ...
Yacouba Cissé, Lang Bai, Min-Ting Chen
openaire +3 more sources
The genomic map of total lncRNAs and deregulated LncRNAs in chromosomes of mouse. [PDF]
, 2013 The distribution of LncRNAs in chromosomes of mouse is marked in blue. The upregulated LncRNAs are highlighed in red and the downregulated lncRNAs are highlighted in green.
Youfei Guan (209018) +8 more
core +1 more source
Small RNA pathways in mammalian oocytes
FEBS Open Bio, EarlyView.Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley +1 more source
Los ARNs no codificantes largos y su vinculación con las patologías testiculares
Anales de la Facultad de Medicina, 2019 Si bien la porción del genoma destinada a la síntesis de proteínas es muy pequeña, actualmente se sabe que casi todo el genoma se expresa bajo forma de ARNs no codificantes.
María F. Trovero, Adriana Geisinger
doaj +1 more source
Distribution of Repeat Elements across lncRNAs. [PDF]
, 2014 Distribution of different Repeat Families across lncRNAs in (a) human and (b) mouse compared to protein coding transcripts. (c) Repeat associated lncRNA subtypes in human and mouse.
Sudipto Saha (64064) +4 more
core +1 more source