Results 81 to 90 of about 117,416 (307)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

Transcriptome Profiling of Transposon-Derived Long Non-coding RNAs Response to Hormone in Strawberry Fruit Development

Frontiers in Plant Science, 2022
Strawberry is an economically grown horticulture crop required for fruit consumption. The ripening of its fruit is a complex biological process regulated by various hormones.
Xi Chen, Xi Chen, Chengdong Wang, Bing He, Zifan Wan, Zifan Wan, Yukun Zhao, Yukun Zhao, Fengqin Hu, Yuanda Lv   +9 more
doaj   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Identification of key pathways and molecular players potentially involved in endometrial cancer metastasis through integrated bioinformatics analyses [PDF]

BioImpacts
Introduction: Endometrial cancer (EC) is a particularly frequent gynecological cancer, and metastasis is the leading cause of death in patients with EC.
Maryam Rezazadeh, Shahla Danaei-Mehrabad, Nahideh Afshar Zakariya, Fatemeh Kazemi, Marziyeh Sadat Moslehian, Amin Tamadon, Reza Shirazi, Mahdi Mahdipour, Parvin Hakimi   +8 more
doaj   +1 more source

Long non-coding RNAs as novel components in the TP53 pathway [PDF]

, 2016
C
Koster, Jan, Lefever, Steve, Lindner, Sven, Mestdagh, Pieter, Rombaut, Dries, Schulte, Johannes, van Sluis, Peter, Vandesompele, Jo, Versteeg, Rogier   +8 more
core   +2 more sources

The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter. [PDF]

, 2019
A major challenge in finding a cure for HIV-1/AIDS is the difficulty in identifying and eradicating persistent reservoirs of replication-competent provirus.
Chang, Kungyen, Chao, Ti-Chun, Karris, Maile Ann Young, Kaul, Marcus, Li, Zhonghan, Qin, Yue, Rana, Tariq M, Sanchez, Ana, Singh, Gatikrushna, Tiwari, Shashi Kant, Yau, Edwin, Zhang, Qiong   +11 more
core   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Long Non-Coding RNAs in Brown Adipose Tissue

Diabetes, Metabolic Syndrome and Obesity, 2020
Songjia Lai,1,* Kun Du,1,* Yu Shi,1 Cao Li,1 Guoze Wang,1,2 Shenqiang Hu,1 Xianbo Jia,1 Jie Wang,1 Shiyi Chen1 1Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130 ...
Lai S, Du K, Shi Y, Li C, Wang G, Hu S, Jia X, Wang J, Chen S   +8 more
doaj  

Identification of long non-coding RNAs in the early growth stage of Holstein mammary gland

The European Zoological Journal, 2020
In Holsteins, emerging evidence suggests that long non-coding RNAs (lncRNAs) are actively involved in the regulation of mammary gland development. However, the lncRNA expression pattern in the early growth stage of Holstein mammary gland remains little ...
K. Du, A.-Y. Ren, M.-C. Cai, G.-Z. Wang, X.-B. Jia, S.-Q. Hu, J. Wang, S.-Y. Chen, S.-J. Lai   +8 more
doaj   +1 more source

lncRNA/MicroRNA interactions in the vasculature [PDF]

Clinical Pharmacology & Therapeutics, 2016
MicroRNA (miRNA) have gained widespread attention for their role in diverse vascular processes including angiogenesis, apoptosis, proliferation, and migration. Despite great understanding of miRNA expression and function, knowledge of long noncoding RNA (lncRNA) molecular mechanisms still remains limited.
Ballantyne, Margaret D, McDonald, Robert A, Baker, Andrew H   +2 more
openaire   +4 more sources