Results 81 to 90 of about 31,278 (264)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Characterization analysis of lncRNAs. [PDF]

, 2016
(a) The length compassion analysis of lncRNA and mRNA. X axis indicates the length of lncRNAs and mRNAs (bp), while Y axis represents the frequent count.
Junjuan Wang (2833112), Delong Wang (1794073), Weili Fan (2833115), Xiaoge Wang (419278), Xiugui Chen (2833109), Wuwei Ye (2833100), Shuai Wang (109515), Lixue Guo (762312), Min Mu (2833103), Zujun Yin (168521), Xuke Lu (2833106)   +10 more
core   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Autophagy-related lncRNAs and exosomal lncRNAs in colorectal cancer: focusing on lncRNA-targeted strategies

Cancer Cell International
Autophagy is a cellular process that involves the degradation and recycling of cellular components, including damaged proteins and organelles. It is an important mechanism for maintaining cellular homeostasis and has been implicated in various diseases, including cancer.
Yan Dong, Yiwei He, Yanna Geng, Meimei Wei, Xiaomei Zhou, Jianlun Lian, Jamal Hallajzadeh   +6 more
openaire   +3 more sources

A Novel Predictive Model Associated with Osteosarcoma Metastasis

Cancer Management and Research, 2021
Han Zhang,1,2 Guanhong Chen,2 Xiajie Lyu,3 Chun Rong,4 Yingzhen Wang,1 Ying Xu,2 Chengyu Lyu1 1Department of Orthopaedics, The Affiliated Hospital of Qingdao University, Qingdao City, Shandong Province, People’s Republic of China; 2Department of ...
Zhang H, Chen G, Lyu X, Rong C, Wang Y, Xu Y, Lyu C   +6 more
doaj  

Identification of lncRNAs involved in biological regulation in early age-related macular degeneration [PDF]

, 2017
Wei Zhu,1,* Yi-Fang Meng,1,* Qian Xing,1 Jian-Jun Tao,1 Jiong Lu,1 Yan Wu2 1Department of Ophthalmology, Changshu No. 2 People’s Hospital, Changshu, China; 2Department of Ophthalmology, First Hospital Affiliated to Soochow University, Suzhou ...
Lu J, Meng YF, Zhu W, Xing Q, Tao JJ, Wu Y   +5 more
core  

EVlncRNA-Dpred: improved prediction of experimentally validated lncRNAs by deep learning [PDF]

, 2022
Long non-coding RNAs (lncRNAs) played essential roles in nearly every biological process and disease. Many algorithms were developed to distinguish lncRNAs from mRNAs in transcriptomic data and facilitated discoveries of more than 600 000 of lncRNAs ...
Wang, Jihua, Zhou, Bailing, Zhou, Yaoqi, Ji, Baohua, Huang, Pingping, Yu, Xue, Ding, Maolin, Feng, Jing, Zhang, Junye, Cao, Zanxia, Yang, Yuedong   +10 more
core   +1 more source

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

ccanovi/lncRNAs: lncRNAs [PDF]

Identification of long intergenic non-coding RNAs (lincRNAs) in Norway spruce somatic embryogenesis (SE)
IrynaShutava, Nicolas Delhomme, ccanovi
core   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source