Results 51 to 60 of about 73,797 (157)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Molecular Interactions of lncRNAs: Cellular Fate Determination and Tissue Regeneration [PDF]

Journal of Cell and Molecular Research, 2015
LncRNAs (long non-coding RNAs) are responsible to control the degradation process, RNA stability, orchestration, inhibition, transcription and histone modification etc.
Monireh Bahrami, Muhammad Irfan-Maqsood
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Transcriptome Profiling of Transposon-Derived Long Non-coding RNAs Response to Hormone in Strawberry Fruit Development

Frontiers in Plant Science, 2022
Strawberry is an economically grown horticulture crop required for fruit consumption. The ripening of its fruit is a complex biological process regulated by various hormones.
Xi Chen, Xi Chen, Chengdong Wang, Bing He, Zifan Wan, Zifan Wan, Yukun Zhao, Yukun Zhao, Fengqin Hu, Yuanda Lv   +9 more
doaj   +1 more source

lncRNA-ACOD1: GOT2 has got a lncRNA cofactor

Non-coding RNA Investigation, 2018
In spite of the limited information encoded in viral genomes, viruses can infect and replicate in complex organisms. Evolution has selected viruses able to use cellular factors to achieve viral entry, viral protein expression, and viral replication, packaging and release.
Marina Barriocanal, Puri Fortes
openaire   +1 more source

Identification of key pathways and molecular players potentially involved in endometrial cancer metastasis through integrated bioinformatics analyses [PDF]

BioImpacts
Introduction: Endometrial cancer (EC) is a particularly frequent gynecological cancer, and metastasis is the leading cause of death in patients with EC.
Maryam Rezazadeh, Shahla Danaei-Mehrabad, Nahideh Afshar Zakariya, Fatemeh Kazemi, Marziyeh Sadat Moslehian, Amin Tamadon, Reza Shirazi, Mahdi Mahdipour, Parvin Hakimi   +8 more
doaj   +1 more source

UntRIG(er)ing lncRNAs [PDF]

Molecular Cell, 2018
In a recent Cell paper, Jiang et al. (2018) have shown that lnc-Lsm3b, a long non-coding RNA induced by type I IFN late in the infection in mouse macrophages, prevents further activation of RIG-I acting as a decoy for RIG-I.
openaire   +3 more sources

Novel human lncRNA–disease association inference based on lncRNA expression profiles [PDF]

Bioinformatics, 2013
Abstract Motivation: More and more evidences have indicated that long–non-coding RNAs (lncRNAs) play critical roles in many important biological processes. Therefore, mutations and dysregulations of these lncRNAs would contribute to the development of various complex diseases.
Xing, Chen, Gui-Ying, Yan
openaire   +2 more sources

Identification of long non-coding RNAs in the early growth stage of Holstein mammary gland

The European Zoological Journal, 2020
In Holsteins, emerging evidence suggests that long non-coding RNAs (lncRNAs) are actively involved in the regulation of mammary gland development. However, the lncRNA expression pattern in the early growth stage of Holstein mammary gland remains little ...
K. Du, A.-Y. Ren, M.-C. Cai, G.-Z. Wang, X.-B. Jia, S.-Q. Hu, J. Wang, S.-Y. Chen, S.-J. Lai   +8 more
doaj   +1 more source

LncRNAs in pancreatic cancer

Oncotarget, 2016
Pancreatic cancer (PC) is one of the most common causes of cancer-related death. The underlying mechanism of PC is not completely understood at present. Studies in recent years have demonstrated that long non-coding RNAs (lncRNAs) have multiple biological functions in cell growth, differentiation and proliferation.
Huang, Xiaoyi, Zhi, Xiaosong, Gao, Yisha, Ta, Na, Jiang, Hui, Zheng, Jianming   +5 more
openaire   +3 more sources