Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Local Art, Local Action: A Proposal for Deliberating on and about Main Street
Journal of Deliberative Democracy, 2013 In every campaign, politicians make promises. They spell out their hopes and dreams for their constituents and describe the dystopia that would exist should their opponent be elected instead.
Anna Wolfe
doaj +2 more sources
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
The Impact of Local Structures on Socio-Political Action;Case: Baluch in Iran
تحقيقات جغرافيايی, 2018 Introduction and Background There is a relationship between local structures and individual and social actions. These relationships are formed before they are determined. These structures are not entirely objective frameworks.
barzin Zarqami, Ebrahim Roumina
doaj
Global issues, local action: exploring local governments use of research in "tackling climate change and its impacts on health" in Victoria, Australia. [PDF]
BMC Health Serv Res, 2023 Dam J, Wright A, Bos JJA, Bragge P.
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Local Action of Increased Pressure Induces Hyperpolarization Electrical Signals and Influences Photosynthetic Light Reactions in Wheat Plants. [PDF]
Plants (Basel), 2023 Yudina L +4 more
europepmc +1 more source
The Power of Local Action: Learning and Exploring Possibilities for Local Humanitarian Leadership
, 2020 The Power of Local Action is an Oxfam learning compendium on local humanitarian leadership (LHL) that arose out of learning events and global meetings held in 2019 in Nairobi, Mexico City, Jakarta and Istanbul, and draws from the ...
van den Berg, Michelle +6 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source