Results 11 to 20 of about 5,302,191 (386)

The Thermodynamics of General and Local Anesthesia [PDF]

Biophysical Journal, 2014
General anesthetics are known to cause depression of the freezing point of transitions in biomembranes. This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusion from the solid phase. Such a generic law provides physical justification of the famous Meyer-Overton rule.
Graesboll, Kaare, Sasse-Middelhoff, Henrike, Heimburg, Thomas   +2 more
openaire   +7 more sources

Genetic liability for diet-derived circulating antioxidants, oxidative stress, and risk of osteoarthritis: a Mendelian randomization study

Frontiers in Nutrition, 2023
BackgroundAlthough well-documented, the causal relationships between diet-derived circulating antioxidants, oxidative stress, and osteoarthritis (OA) are equivocal.
Yidan Tang, Yidan Tang, Xiaolin Xu, Xiaolin Xu, Shuangyi Zhang, Shuangyi Zhang, Weishuang Kong, Weiyi Zhang, Weiyi Zhang, Tao Zhu, Tao Zhu   +10 more
doaj   +1 more source

General Versus Local Anesthesia With Conscious Sedation in Transcatheter Aortic Valve Implantation

Circulation, 2020
Background: In clinical practice, local anesthesia with conscious sedation (CS) is performed in roughly 50% of patients undergoing transcatheter aortic valve replacement.
H. Thiele, T. Kurz, H. Feistritzer, G. Stachel, P. Hartung, P. Lurz, I. Eitel, C. Marquetand, H. Nef, O. Doerr, U. Vigelius-Rauch, A. Lauten, U. Landmesser, S. Treskatsch, M. Abdel-Wahab, M. Sandri, D. Holzhey, M. Borger, J. Ender, H. Ince, A. Öner, R. Meyer‐Saraei, R. Hambrecht, A. Fach, Thomas Augenstein, N. Frey, I. König, R. Vonthein, Yvonne Rückert, A. Funkat, S. Desch, Astrid E. Berggreen, M. Heringlake, S. de Waha‐Thiele   +33 more
semanticscholar   +1 more source

The feasibility of local anesthesia for the surgical treatment of umbilical hernia: a systematic review of the literature [PDF]

, 2017
Background: Yearly approximately 4500 umbilical hernias are repaired in The Netherlands, mostly under general anesthesia. The use of local anesthesia has shown several advantages in groin hernia surgery.
Jairam, A.P. (An), Jeekel, J. (Hans), Lange, J.F. (Johan), Muysoms, F.E. (Filip), Posthuma-Kaufmann, R. (Ruth)   +4 more
core   +8 more sources

History of anesthesia usage in dentistry [PDF]

Stomatološki glasnik Srbije, 2005
Since prehistoric times, man has sought ways to lessen pain. With varying degrees of success he has utilized: opium, nerve compresses, cold, hypnosis, etc.
Koković Vladimir
doaj   +1 more source

Advances in the Understanding of Two-Pore Domain TASK Potassium Channels and Their Potential as Therapeutic Targets

Molecules, 2022
TWIK-related acid-sensitive K+ (TASK) channels, including TASK-1, TASK-3, and TASK-5, are important members of the two-pore domain potassium (K2P) channel family. TASK-5 is not functionally expressed in the recombinant system.
Xueming Fan, Yongzhi Lu, Guizhi Du, Jin Liu   +3 more
doaj   +1 more source

Dissolving Microneedles for Rapid and Painless Local Anesthesia

Pharmaceutics, 2020
Microneedles are emerging drug delivery methods for painless treatment. The current study tested dissolving microneedles containing lidocaine (Li-DMN) for use in local anesthesia.
Byeong-min Lee, Chisong Lee, S. F. Lahiji, U. Jung, G. Chung, Hyungil Jung   +5 more
semanticscholar   +1 more source

Light-triggered release of conventional local anesthetics from a macromolecular prodrug for on-demand local anesthesia

Nature Communications, 2020
An on-demand anesthetic that would only take effect when needed and where the intensity of anesthesia could be easily adjustable according to patients’ needs would be highly desirable.
Wei Zhang, T. Ji, Yang Li, Yueqin Zheng, Manisha Mehta, Chao Zhao, Andong Liu, D. Kohane   +7 more
semanticscholar   +1 more source

Structural Modification in Anesthetic Drug Development for Prodrugs and Soft Drugs

Frontiers in Pharmacology, 2022
Among the advancements in drug structural modifications, the increased focus on drug metabolic and pharmacokinetic properties in the anesthetic drug design process has led to significant developments.
Chaoyi Deng, Chaoyi Deng, Jin Liu, Jin Liu, Wensheng Zhang, Wensheng Zhang   +5 more
doaj   +1 more source

Genetically supported causality between gut microbiota, gut metabolites and low back pain: a two-sample Mendelian randomization study

Frontiers in Microbiology, 2023
BackgroundPrevious studies have implicated a vital association between gut microbiota/gut microbial metabolites and low back pain (LBP), but their causal relationship is still unclear.
Mengchan Su, Mengchan Su, Yidan Tang, Yidan Tang, Weishuang Kong, Shuangyi Zhang, Shuangyi Zhang, Tao Zhu, Tao Zhu   +8 more
doaj   +1 more source