Results 1 to 10 of about 10,043,064 (337)

Advances in Oral Drug Delivery Systems: Challenges and Opportunities

Pharmaceutics, 2023
The oral route is the most preferred route for systemic and local drug delivery. However, the oral drug delivery system faces the harsh physiological and physicochemical environment of the gastrointestinal tract, which limits the bioavailability and ...
Jie Lou, Hongli Duan, Qin Qin, Zhipeng Teng, Fengxu Gan, Xiaofang Zhou, Xing Zhou   +6 more
doaj   +2 more sources

Iontophoretic Drug Delivery in the Oral Cavity

Pharmaceutics, 2018
Iontophoresis is a noninvasive method to enhance systemic and local drug delivery by the application of an electric field. For systemic drug delivery in the oral cavity, iontophoresis was studied primarily for transbuccal delivery.
Apipa Wanasathop, S. Kevin Li
doaj   +1 more source

Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy

Gels, 2022
At present, an oral tumor is usually treated by surgery combined with preoperative or postoperative radiotherapies and chemotherapies. However, traditional chemotherapies frequently result in substantial toxic side effects, including bone marrow ...
Yiwen Zhao, Bei Ran, Xi Xie, Wanrong Gu, Xiuwen Ye, Jinfeng Liao   +5 more
doaj   +1 more source

Statins: A new era in local drug delivery

Journal of Pharmacy and Bioallied Sciences, 2012
Periodontitis is an inflammatory disease of the supporting tissues of the teeth, caused by a group of specific microorganisms. Aggressive forms of periodontitis can be localized or generalized.
Sugumari Elavarasu, Thanga Kumaran Suthanthiran, Devisree Naveen   +2 more
doaj   +1 more source

Advances in peptide-drug conjugate-based supramolecular hydrogel systems for local drug delivery

Medicine in Drug Discovery, 2022
Peptide-drug conjugate (PDC) systems consisting of peptide, linker and drug, have attracted extensive attention in drug delivery applications. With the assistance of peptides, the PDC systems have competitive advantages over other drug delivery vehicles,
Qi Shang, Yun Su, Faith Leslie, Mingjiao Sun, Feihu Wang   +4 more
doaj   +1 more source

The potential of silk and silk-like proteins as natural mucoadhesive biopolymers for controlled drug delivery

Frontiers in Chemistry, 2015
Drug delivery across mucus membranes is a particularly effective route of administration due to the large surface area. However, the unique environment present at the mucosa necessitates altered drug formulations designed to (1) deliver sensitive ...
Amanda E Brooks
doaj   +1 more source

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Pharmaceutics, 2020
Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to ...
Sang Hoon Lee, Rajiv Bajracharya, Jeong Youn Min, Ji-Won Han, Byeong Ju Park, Hyo-Kyung Han   +5 more
doaj   +1 more source

Advances in local drug delivery technologies for improved rheumatoid arthritis therapy.

Advanced Drug Delivery Reviews
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by an inflammatory microenvironment and cartilage erosion within the joint cavity.
Xiao-Ran An, Jia-Pei Yang, Xiaolin Cui, Jiaxuan Zhao, Chen-Wei Jiang, Ming-Lu Tang, Yabing Dong, Long-Fei Lin, Hui Li, Fei-Hu Wang   +9 more
semanticscholar   +1 more source

Cascade-targeted delivery platform enhances antigen cross-presentation and STING activation for durable cellular immunity

Bioactive Materials
Achieving robust and durable cellular immunity remains a key challenge in the development of subunit vaccines, primarily due to inefficient antigen cross-presentation and inadequate immune activation.
Yuan Xue, Shuting Bai, Yating Wang, Jiaxing Feng, Kun Xiong, Xue Tang, Chunting He, Yanhua Xu, Hongling Yu, Tianyi Luo, Qing Lin, Xun Sun, Ling Zhang, Zhirong Zhang, Tao Gong   +14 more
doaj   +1 more source

Herbal Local Drug Delivery: A Narrative Review

Indian Journal of Dental Sciences
Periodontitis is a complex and chronic inflammation of the periodontium and can be diagnosed clinically by gingival inflammation, attachment loss, and loosening of teeth.
Akanksha Mohan Karale, Pramod Waghmare, Vidya M. Dodwad, Avneet Kaur   +3 more
doaj   +1 more source