Results 41 to 50 of about 885,184 (197)

Local Drug Delivery for Prevention of Hearing Loss

Frontiers in Cellular Neuroscience, 2019
Systemic delivery of therapeutics for targeting the cochlea to prevent or treat hearing loss is challenging. Systemic drugs have to cross the blood-labyrinth barrier (BLB).
Leonard P. Rybak, Leonard P. Rybak, Asmita Dhukhwa, Debashree Mukherjea, Vickram Ramkumar   +4 more
doaj   +1 more source

Deformable Nanovesicles Synthesized through an Adaptable Microfluidic Platform for Enhanced Localized Transdermal Drug Delivery. [PDF]

, 2017
Phospholipid-based deformable nanovesicles (DNVs) that have flexibility in shape offer an adaptable and facile method to encapsulate diverse classes of therapeutics and facilitate localized transdermal delivery while minimizing systemic exposure. Here we
Alam, Mohammad Parvez, Campagna, Jesus, Hokugo, Akishige, John, Varghese, Nishimura, Ichiro, Sharma, Shivani, Spilman, Patricia, Subbiah, Naren   +7 more
core   +2 more sources

Strategic Approaches for Colon Targeted Drug Delivery: An Overview of Recent Advancements

Pharmaceutics, 2020
Colon targeted drug delivery systems have gained a great deal of attention as potential carriers for the local treatment of colonic diseases with reduced systemic side effects and also for the enhanced oral delivery of various therapeutics vulnerable to ...
Sang Hoon Lee, Rajiv Bajracharya, Jeong Youn Min, Ji-Won Han, Byeong Ju Park, Hyo-Kyung Han   +5 more
doaj   +1 more source

Vascular Regeneration by Local Growth Factor Release Is Self-Limited by Microvascular Clearance [PDF]

, 2008
Background— The challenge of angiogenesis science is that stable sustained vascular regeneration in humans has not been realized despite promising preclinical findings.
Edelman, Elazer R., Hayward, Alison, Hwang, Chao-Wei, Le, Kha N., Lovich, Mark A., Tzafriri, A. Rami   +5 more
core   +1 more source

Prevention of Restenosis by Local Drug Delivery

Journal of Cardiovascular Pharmacology and Therapeutics, 1996
Local drug therapy for preventing restenosis after angioplasty has been investigated for over a decade. Biologically active agents ranging from drugs to genes can be delivered locally using a wide variety of catheters. Microspheres, liposomes, and polymers have been used to enhance drug retention at the delivery site.
, Makkar, , Eigler, , Litvack, , Forrester   +3 more
openaire   +2 more sources

The potential of silk and silk-like proteins as natural mucoadhesive biopolymers for controlled drug delivery

Frontiers in Chemistry, 2015
Drug delivery across mucus membranes is a particularly effective route of administration due to the large surface area. However, the unique environment present at the mucosa necessitates altered drug formulations designed to (1) deliver sensitive ...
Amanda E Brooks
doaj   +1 more source

Advances in oral transmucosal drug delivery [PDF]

, 2011
Original article can be found at : http://sciencedirect.com/ Copyright ElsevierThe successful delivery of drugs across the oral mucosa represents a continuing challenge, as well as a great opportunity.
Brown, Marc, Liu, Fang, Patel, Viralkumar F.   +2 more
core   +1 more source

Investigation of particle accumulation, chemosensitivity and thermosensitivity for effective solid tumor therapy using thermosensitive liposomes and hyperthermia [PDF]

, 2016
Doxorubicin (Dox) loaded thermosensitive liposomes (TSLs) have shown promising results for hyperthermia-induced local drug delivery to solid tumors. Typically, the tumor is heated to hyperthermic temperatures (41-42 °C), which induced intravascular drug ...
Bolkestein, M. (Michiel), Eggermont, A.M.M. (Alexander), Grüll, H. (Holger), Hagen, T.L.M. (Timo) ten, Jong, M. (Marcel) de, Koning, G.A. (Gerben), Lokerse, W.J.M. (Wouter)   +6 more
core   +3 more sources

Microtransformers: controlled microscale navigation with flexible robots [PDF]

, 2018
Artificial microswimmers are a new technology with promising microfluidics and biomedical applications, such as directed cargo transport, microscale assembly, and targeted drug delivery. A fundamental barrier to realising this potential is the ability to
Montenegro-Johnson, Thomas D.
core   +2 more sources

Cascade-targeted delivery platform enhances antigen cross-presentation and STING activation for durable cellular immunity

Bioactive Materials
Achieving robust and durable cellular immunity remains a key challenge in the development of subunit vaccines, primarily due to inefficient antigen cross-presentation and inadequate immune activation.
Yuan Xue, Shuting Bai, Yating Wang, Jiaxing Feng, Kun Xiong, Xue Tang, Chunting He, Yanhua Xu, Hongling Yu, Tianyi Luo, Qing Lin, Xun Sun, Ling Zhang, Zhirong Zhang, Tao Gong   +14 more
doaj   +1 more source