Results 31 to 40 of about 10,043,064 (337)
High-Precision 3D Printing of Microporous Cochlear Implants for Personalized Local Drug Delivery. [PDF]
J Funct Biomater, 2023 Hearing loss is a highly prevalent multifactorial disorder affecting 20% of the global population. Current treatments using the systemic administration of drugs are therapeutically ineffective due to the anatomy of the cochlea and the existing blood ...
Isaakidou A +3 more
europepmc +2 more sources
Inflammation-specific targeted carriers for local drug delivery to inflammatory bowel disease.
Biomaterials, 2022 Delivering drugs directly to the inflamed intestinal sites to treat inflammatory bowel disease (IBD), particularly Crohn's and ulcerative colitis, is highly challenging.
Niranjan G. Kotla +11 more
semanticscholar +1 more source
F1000Research, 2023 Periodontitis is the chronic inflammation of tooth-supporting tissues that leads to loss of tooth support if untreated. Conventional therapy for periodontitis (mechanical removal of microbial biofilm and oral hygiene enforcement) is augmented by anti ...
Shashikiran Shanmugasundaram +2 more
doaj +1 more source
Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery
Gels, 2020 Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation,
Esfandyar Askari +7 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2022 Chronic osteomyelitis is one of the most challenging diseases in orthopedic treatment. It is usually treated with intravenous antibiotics and debridement in clinical practice, which also brings systemic drug side effects and bone defects.
Yi-Xiu Liu, Xu Li, A. Liang
semanticscholar +1 more source
Turmeric as a local drug delivery in periodontitis: A review of literature
CHRISMED Journal of Health and Research, 2022 Periodontitis is a multifactorial disease. Traditional methods like toothbrushing and manual scaling and root planing are the treatment of choice. However, these methods are time-consuming and not fully effective.
Arnav Mukherji, Sinthiya Bose
doaj +1 more source
Release of functional dexamethasone by intracellular enzymes: A modular peptide-based strategy for ocular drug delivery [PDF]
, 2020 Tissue barriers limit drug delivery in the eye. Therefore, retinal diseases are treated with intravitreal injections. Delivery systems with reduced dosing frequency and/or cellular drug delivery properties are needed.
Sadeghi, Amir +7 more
core +1 more source
Local Delivery of Therapeutics to the Cochlea Using Nanoparticles and Other Biomaterials
Pharmaceuticals, 2022 Hearing loss negatively impacts the well-being of millions of people worldwide. Systemic delivery of ototherapeutics has limited efficacy due to severe systemic side effects and the presence of the blood–labyrinth barrier that selectively limits or ...
Shreshtha Dash +2 more
doaj +1 more source
Photonic and magnetic materials for on-demand local drug delivery.
Advanced Drug Delivery Reviews, 2022 Nanomedicine has been considered a promising tool for biomedical research and clinical practice in the 21st century because of the great impact nanomaterials could have on human health.
I. Armenia +6 more
semanticscholar +1 more source
Transdermal drug delivery by localized intervention [PDF]
IEEE Engineering in Medicine and Biology Magazine, 2009 Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free manner. These openings are similar in dimension to commonly experienced scratches and nicks on the skin.
Weaver, James C. +2 more
openaire +4 more sources