Results 31 to 40 of about 885,184 (197)

Local BDNF Delivery to the Injured Cervical Spinal Cord using an Engineered Hydrogel Enhances Diaphragmatic Respiratory Function. [PDF]

, 2018
We developed an innovative biomaterial-based approach to repair the critical neural circuitry that controls diaphragm activation by locally delivering brain-derived neurotrophic factor (BDNF) to injured cervical spinal cord.
Ghosh, Biswarup, Lepore, Angelo C., Nong, Jia, Trovillion, Victoria A., Urban, Mark W., Wang, Zhicheng, Wright, Megan C., Zhang, Zhiling, Zhong, Yinghui   +8 more
core   +2 more sources

Drug Delivery Systems for Local Anesthetics

Recent Patents on Drug Delivery & Formulation, 2010
Although technological innovations in the area of drug delivery claim for varied benefits, increasing the drug therapeutic index for human clinical application is the main goal pursued. Drug delivery systems for local anesthetics (LA) have attracted researchers due to many biomedical advantages associated to their application. Formulation approaches to
de Paula, Eneida, Cereda, Cíntia M.S., Tofoli, Giovana R., Franz-Montan, Michelle, Fraceto, Leonardo F., De Araújo, Daniele R.   +5 more
openaire   +3 more sources

Advances in Oral Drug Delivery Systems: Challenges and Opportunities

Pharmaceutics, 2023
The oral route is the most preferred route for systemic and local drug delivery. However, the oral drug delivery system faces the harsh physiological and physicochemical environment of the gastrointestinal tract, which limits the bioavailability and ...
Jie Lou, Hongli Duan, Qin Qin, Zhipeng Teng, Fengxu Gan, Xiaofang Zhou, Xing Zhou   +6 more
doaj   +1 more source

Iontophoretic Drug Delivery in the Oral Cavity

Pharmaceutics, 2018
Iontophoresis is a noninvasive method to enhance systemic and local drug delivery by the application of an electric field. For systemic drug delivery in the oral cavity, iontophoresis was studied primarily for transbuccal delivery.
Apipa Wanasathop, S. Kevin Li
doaj   +1 more source

Developments on the Smart Hydrogel-Based Drug Delivery System for Oral Tumor Therapy

Gels, 2022
At present, an oral tumor is usually treated by surgery combined with preoperative or postoperative radiotherapies and chemotherapies. However, traditional chemotherapies frequently result in substantial toxic side effects, including bone marrow ...
Yiwen Zhao, Bei Ran, Xi Xie, Wanrong Gu, Xiuwen Ye, Jinfeng Liao   +5 more
doaj   +1 more source

Nasal Drug Delivery Systems: An Overview [PDF]

, 2015
Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R., Ghori, Muhammad U., Mahdi, Mohammed H., Smith, Alan M.   +3 more
core   +1 more source

Enriching Discourse on Public Domains [PDF]

, 2006
Studying microvascular responses to iontophoresis of vasoconstricting drugs contributes to a better understanding of the regulatory mechanisms of cutaneous vessels, but measuring these responses with laser-Doppler flowmetry at basal blood flow conditions
Baiat, Yashma, Henricson, Joakim, Sjöberg, Folke   +2 more
core   +2 more sources

Statins: A new era in local drug delivery

Journal of Pharmacy and Bioallied Sciences, 2012
Periodontitis is an inflammatory disease of the supporting tissues of the teeth, caused by a group of specific microorganisms. Aggressive forms of periodontitis can be localized or generalized.
Sugumari Elavarasu, Thanga Kumaran Suthanthiran, Devisree Naveen   +2 more
doaj   +1 more source

Advances in peptide-drug conjugate-based supramolecular hydrogel systems for local drug delivery

Medicine in Drug Discovery, 2022
Peptide-drug conjugate (PDC) systems consisting of peptide, linker and drug, have attracted extensive attention in drug delivery applications. With the assistance of peptides, the PDC systems have competitive advantages over other drug delivery vehicles,
Qi Shang, Yun Su, Faith Leslie, Mingjiao Sun, Feihu Wang   +4 more
doaj   +1 more source

Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter pylori [PDF]

, 2015
Objectives: There are various obstacles in the eradication of Helicobacter.pylori (H. pylori) infections, including low antibiotic levels and poor accessibility of the drug at the site of the infection.
Adebisi, Adebisi, Adeola O. Adebisi, Ahuja, Akiyama, Bai, Bajpai, Barbara R. Conway, Batchelor, Bazzoli, Boddupalli, Cammarota, Castro, Chun, Desai, Dunn, Dupuy, Erah, Erah, Ernst, Gal, Georgopoulos, Gåserød, Higuchi, Hixson, Iijima, Ikeda, Ishak, Kawahara, Khanvilkar, Kohri, Korsmeyer, Lee, Lehmann, Malfertheiner, Miyazaki, Moore, Murata, Murray, Najib, Nakagawa, Nayak, Norris, Park, Pasparakis, Pereira, Peter R. Laity, Peterson, Rajinikanth, Romero, Rothenbacher, Singh, Smrdel, Stops, Suerbaum, Suzuki, Umamaheshwari, Varum, Whitehead, Østberg   +59 more
core   +1 more source