Results 11 to 20 of about 302,578 (216)
Bioadhesive Nanoparticles for Local Drug Delivery [PDF]
International Journal of Molecular Sciences, 2022 Local drug delivery is an effective strategy for achieving direct and instant therapeutic effects. Current clinical treatments have fallen short and are limited by traditional technologies. Bioadhesive nanoparticles (NPs), however, may be a promising carrier for optimized local drug delivery, offering prolonged drug retention time and steadily ...
Yaqi Ouyang, Lingyun Xiao
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Nanoscale systems for local drug delivery
Nano Today, 2019 Many diseases and conditions affect a relatively localized area of the body. They can be treated either by direct deposition of drug in the target area, or by giving the drug systemically. Here we review nanoparticle-based approaches to achieving both.
Tianjiao Ji, Daniel S Kohane
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Transdermal drug delivery by localized intervention [PDF]
IEEE Engineering in Medicine and Biology Magazine, 2009 Both field-confined skin electroporation and microscissioning offer minimally invasive methods for delivering drugs across skin and nail with minimal sensation. Both methods create high permeability pathways in a pain-free manner. These openings are similar in dimension to commonly experienced scratches and nicks on the skin.
Weaver, James C. +2 more
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Local drug delivery to prevent restenosis [PDF]
Journal of Vascular Surgery, 2013 Despite significant advances in vascular biology, bioengineering, and pharmacology, restenosis remains a limitation to the overall efficacy of vascular reconstructions, both percutaneous and open. Although the pathophysiology of intimal hyperplasia is complex, a number of drugs and molecular tools have been identified that can prevent restenosis ...
Seedial, Stephen M. +6 more
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Local drug delivery drugs and systems [PDF]
International Journal of Applied Dental Sciences, 2020 Periodontal disease is a multifactorial disease that affects the supporting tissues resulting in destruction of supporting structure. Non surgical periodontal treatment has been a cornerstone in the management of periodontics. Local drug delivery system is the application of anti microbial or anti infective agent that would target pathogenic micro ...
Dr. Uma Sudhakar +3 more
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Stent development and local drug delivery [PDF]
British Medical Bulletin, 2001 Stent implantation has become the new standard angioplasty procedure. In-stent re-stenosis remains the major limitation of coronary stenting. Re-stenosis is related to patient-, lesion- and procedure-specific factors. Patient-specific factors can not be influenced to any extent.
Regar, Evelyn +2 more
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Drug Delivery Systems for Local Anesthetics
Recent Patents on Drug Delivery & Formulation, 2010 Although technological innovations in the area of drug delivery claim for varied benefits, increasing the drug therapeutic index for human clinical application is the main goal pursued. Drug delivery systems for local anesthetics (LA) have attracted researchers due to many biomedical advantages associated to their application. Formulation approaches to
de Paula, Eneida +5 more
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Prevention of Restenosis by Local Drug Delivery
Journal of Cardiovascular Pharmacology and Therapeutics, 1996 Local drug therapy for preventing restenosis after angioplasty has been investigated for over a decade. Biologically active agents ranging from drugs to genes can be delivered locally using a wide variety of catheters. Microspheres, liposomes, and polymers have been used to enhance drug retention at the delivery site.
, Makkar +3 more
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Nucleoside‐Based Self‐Assembling Drugs for Localized Drug Delivery [PDF]
ChemMedChem, 2018 AbstractWe have synthesized a range of gelators based on the nucleoside analogues gemcitabine and lamivudine, characterizing representative gels from the series using rheology and transmission electron microscopy. Growth inhibition studies of gemcitabine derivatives confirmed the feasibility of these compounds as novel treatments, indicating the ...
Kathryn J. Skilling +6 more
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Local Drug Delivery Strategies for Glioblastoma Treatment
Brain Tumor Research and Treatment, 2022 Glioblastoma multiforme (GBM) is a brain tumor notorious for its malignancy. The key reason for the limited efficacy of standard treatment is the high recurrence rate of GBM, even after surgical resection. Hence, intensive postsurgical chemical therapies, such as the systemic delivery of various drugs and/or drug combinations, are typically followed ...
Gi Doo Cha +3 more
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