Synaptic tagging and capture : differential role of distinct calcium/calmodulin kinases in protein synthesis-dependent long-term potentiation [PDF]
, 2010 Weakly tetanized synapses in area CA1 of the hippocampus that ordinarily display long-term potentiation lasting ~3 h (called early-LTP) will maintain a longer-lasting change in efficacy (late-LTP) if the weak tetanization occurs shortly before or after ...
Bito, Haruhiko +5 more
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Synthesis and Localization of Pathogenesis-Related Proteins in Tobacco [PDF]
Molecular and Cellular Biology, 1987 The PR1 family of pathogenesis-related proteins from tobacco (Nicotiana tabacum L.) leaves is induced by a variety of pathogenic and chemical agents and is associated with resistance to tobacco mosaic virus. The majority of the PR1 proteins did not copurify with mesophyll protoplasts (the major cell type of the leaf) isolated from tobacco mosaic virus ...
J P, Carr +4 more
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Frontiers in Cell and Developmental Biology, 2021 Neurons are highly complex polarized cells, displaying an extraordinary degree of spatial compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local protein synthesis is utilized to continually modify the synaptic proteome,
Dipen Rajgor +2 more
doaj +1 more source
A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa [PDF]
, 2018 Nutrients such as amino acids play key roles in shaping the metabolism of microorganisms in natural environments and in host–pathogen interactions.
Cutruzzolà, F. +8 more
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Subcellular Communication Through RNA Transport and Localized Protein Synthesis [PDF]
Traffic, 2010 Interest in the mechanisms of subcellular localization of mRNAs and the effects of localized translation has increased over the last decade. Polarized eukaryotic cells transport mRNA-protein complexes to subcellular sites, where translation of the mRNAs can be regulated by physiological stimuli.
Christopher J, Donnelly +2 more
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Cue-Polarized Transport of β-actin mRNA Depends on 3′UTR and Microtubules in Live Growth Cones
Frontiers in Cellular Neuroscience, 2018 Guidance cues trigger fast responses in axonal growth cones such as directional turning and collapse that require local protein synthesis. An attractive cue-gradient, such as Netrin-1, triggers de novo synthesis of β-actin localized to the near-side ...
Kin-Mei Leung +5 more
doaj +1 more source
Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia [PDF]
, 2006 Growth arrest and DNA damage protein 34 (GADD34) is a multifunctional protein upregulated in response to cellular stress and is believed to mediate DNA repair and restore protein synthesis. In the present study we have examined GADD34 immunoreactivity in
Brown +15 more
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mRNA Trafficking and Local Protein Synthesis at the Synapse [PDF]
Neuron, 1999 The local delivery of mRNA and synthesis of proteins in dendrites provides a solution to the problem of synaptic heterogeneity (Figure 1Figure 1). Early work clearly demonstrating the presence of both mRNAs and polyribosomes in dendrites indicated the capacity for local translation.
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Current Advances in Local Protein Synthesis and Synaptic Plasticity [PDF]
The Journal of Neuroscience, 2006 Local or dendritic protein synthesis is required for long-term functional synaptic change, such as long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD both rely on similar signal transduction cascades, which regulate translation initiation.
Brad E, Pfeiffer, Kimberly M, Huber
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Localized Synaptic Potentiation by BDNF Requires Local Protein Synthesis in the Developing Axon [PDF]
Neuron, 2002 Brain-derived neurotrophic factor (BDNF) is known to promote neuronal survival, guide axonal pathfinding, and participate in activity-dependent synaptic plasticity. In Xenopus nerve-muscle cultures, localized contact of a single BDNF-coated bead with the presynaptic axon resulted in potentiation of transmitter secretion at the developing synapses, but ...
Zhang, Xiao-hui, Poo, Mu-ming
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