Results 211 to 220 of about 46,574 (264)

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Validation of a Gamified Eye-hand Coordination Tool for Post-stroke Upper Limb Assessment Using Tobii EyeX and Leap Motion: A Pilot Study. [PDF]

Ann Neurosci
Choudhary N, Rawat P.
europepmc   +1 more source

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Engagement in advance care planning: effect of playing the card game Anticip'action in a community setting. [PDF]

BMC Public Health
Molnar D, Metoukam Bauquis V, Clavien C.
europepmc   +1 more source

Monitoring cognition in multiple sclerosis via adaptive smartphone games-first insights from a validation study. [PDF]

Front Digit Health
Pless S, Woelfle T, Lorscheider J, Wiencierz A, Reyes Ó, Luque C, Calabrese P, Granziera C, Kappos L.   +8 more
europepmc   +1 more source

Innovative technological resources for Alzheimer's disease care management: A scoping review. [PDF]

Digit Health
Almeida M, Ferreira MC, Fernandes CS.
europepmc   +1 more source

Efficacy of synergistic nursing and flexible play-based approach in children with Bronchial Asthma. [PDF]

Pak J Med Sci
Guo Q, Li B, Hu Y, Liu L, Lv W.
europepmc   +1 more source

An interpretable machine learning model based on MRI radiomics and GAME score for predicting early recurrence after thermal ablation in colorectal liver metastases. [PDF]

Int J Colorectal Dis
Kong Y, Wan L, Yue X, Tang F, Zhou X.
europepmc   +1 more source

Analyzing the impact of the automatic ball strike system in professional baseball through a case study on KBO league data. [PDF]

Sci Rep
Lee K, Han K, Ko J.
europepmc   +1 more source