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The Power and Robustness of Maximum LOD Score Statistics [PDF]
Annals of Human Genetics, 2008 SummaryThe maximum LOD score statistic is extremely powerful for gene mapping when calculated using the correct genetic parameter value. When the mode of genetic transmission is unknown, the maximum of the LOD scores obtained using several genetic parameter values is reported.
Yoo YJ, Mendell NR.
exaly +5 more sources
The Power to Detect Linkage in Complex Disease by Means of Simple LOD-Score Analyses
American Journal of Human Genetics, 1998 SummaryMaximum-likelihood analysis (via LOD score) provides the most powerful method for finding linkage when the mode of inheritance (MOI) is known. However, because one must assume an MOI, the application of LOD-score analysis to complex disease has ...
David A Greenberg, Susan E Hodge
exaly +2 more sources
On the lod score method in linkage analysis
Annals of Human Genetics, 1984 SummaryGenetic epidemiology deals with the interaction of environmental and genetic determinants in common diseases. Linkage analysis is an important branch of this field. The current practice of claiming linkage between two genetic loci when the maximum lod score z(θ) exceeds 3 has not received theoretical justification, whether considered as a ...
Chotai, Jayanti,
openaire +4 more sources
Further Evidence for the Increased Power of LOD Scores Compared with Nonparametric Methods
American Journal of Human Genetics, 1999 SummaryIn genetic analysis of diseases in which the underlying model is unknown, “model free” methods—such as affected sib pair (ASP) tests—are often preferred over LOD-score methods, although LOD-score methods under the correct or even approximately ...
Martina Durner +2 more
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American Journal of Human Genetics, 1998 SummaryWe present a test statistic, the quantitative LOD (QLOD) score, for the testing of both linkage and exclusion of quantitative-trait loci in randomly selected human sibships. As with the traditional LOD score, the boundary values of 3, for linkage,
Grier P Page +2 more
exaly +2 more sources
Monitoring of BNP cardiac biomarker with major emphasis on biosensing methods: A review
Sensors International, 2021 Heart failure (HF) is a prominent disease becomes a crucial cause of morbidity and mortality. It is a severe condition in which the heart is incapable to supply adequate blood to the patient's body. More than 26 million people globally exist with HF.
Twinkle Dahiya +5 more
doaj +1 more source
Linkage replication for chromosomal region 13q32 in schizophrenia: evidence from a Brazilian pilot study on early onset schizophrenia families. [PDF]
PLoS ONE, 2012 We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN® software.
Ary Gadelha +8 more
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Identification of a Locus on the X Chromosome Linked to Familial Membranous Nephropathy
Kidney International Reports, 2021 Introduction: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults and is a leading cause of end-stage renal disease due to glomerulonephritis.
Mallory L. Downie +14 more
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High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. [PDF]
PLoS ONE, 2010 Human lifespan is approximately 25% heritable, and genetic factors may be particularly important for achieving exceptional longevity. Accordingly, siblings of centenarians have a dramatically higher probability of reaching extreme old age than the ...
Steven E Boyden, Louis M Kunkel
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Differences in Odor Identification in Early-Onset and Late-Onset Depression
Brain Sciences, 2022 (1) Background: Odor identification (OI) dysfunction is a potential predictor of developing dementia in late life depression (LLD). However, it is not clear whether patients with early onset depression (EOD) and late onset depression (LOD) may exhibit ...
Meiling Liu +12 more
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