The Power and Robustness of Maximum LOD Score Statistics [PDF]
Annals of Human Genetics, 2008 SummaryThe maximum LOD score statistic is extremely powerful for gene mapping when calculated using the correct genetic parameter value. When the mode of genetic transmission is unknown, the maximum of the LOD scores obtained using several genetic parameter values is reported.
N R Mendell
exaly +5 more sources
Distribution of Model-Based Multipoint Heterogeneity Lod Scores [PDF]
Genetic Epidemiology, 2010 AbstractThe distribution of two‐point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ2 approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating th e distribution of the multipoint HLOD despite its wide application.
Chao Xing, Nathan Morris, Guan Xing
exaly +3 more sources
Monitoring of BNP cardiac biomarker with major emphasis on biosensing methods: A review
Sensors International, 2021 Heart failure (HF) is a prominent disease becomes a crucial cause of morbidity and mortality. It is a severe condition in which the heart is incapable to supply adequate blood to the patient's body. More than 26 million people globally exist with HF.
Twinkle Dahiya +5 more
doaj +1 more source
Linkage replication for chromosomal region 13q32 in schizophrenia: evidence from a Brazilian pilot study on early onset schizophrenia families. [PDF]
PLoS ONE, 2012 We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN® software.
Ary Gadelha +8 more
doaj +1 more source
Identification of a Locus on the X Chromosome Linked to Familial Membranous Nephropathy
Kidney International Reports, 2021 Introduction: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults and is a leading cause of end-stage renal disease due to glomerulonephritis.
Mallory L. Downie +14 more
doaj +1 more source
High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. [PDF]
PLoS ONE, 2010 Human lifespan is approximately 25% heritable, and genetic factors may be particularly important for achieving exceptional longevity. Accordingly, siblings of centenarians have a dramatically higher probability of reaching extreme old age than the ...
Steven E Boyden, Louis M Kunkel
doaj +1 more source
Differences in Odor Identification in Early-Onset and Late-Onset Depression
Brain Sciences, 2022 (1) Background: Odor identification (OI) dysfunction is a potential predictor of developing dementia in late life depression (LLD). However, it is not clear whether patients with early onset depression (EOD) and late onset depression (LOD) may exhibit ...
Meiling Liu +12 more
doaj +1 more source
BMC Medical Genetics, 2008 Background In a previous study of the Hypertension Genetic Epidemiology Network (HyperGEN) we have shown that metabolic syndrome (MetS) risk factors were moderately and significantly associated with echocardiographic (ECHO) left ventricular (LV ...
de Simone Giovanni +10 more
doaj +1 more source
Genetic loci linked to Type 1 Diabetes and Multiple Sclerosis families in Sardinia
BMC Medical Genetics, 2008 Background The Mediterranean island of Sardinia has a strikingly high incidence of the autoimmune disorders Type 1 Diabetes (T1D) and Multiple Sclerosis (MS).
Frongia Paola +39 more
doaj +1 more source
Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction. [PDF]
PLoS ONE, 2016 BACKGROUND:This retrospective, multicenter study aimed to reveal risk predictors for mortality in the intensive care unit (ICU) as well as survival after ICU discharge in patients with acute myeloid leukemia (AML) requiring treatment in the ICU.
Michele Pohlen +22 more
doaj +1 more source