Results 1 to 10 of about 72,586 (301)

The power and robustness of maximum LOD score statistics. [PDF]

Ann Hum Genet, 2008
SummaryThe maximum LOD score statistic is extremely powerful for gene mapping when calculated using the correct genetic parameter value. When the mode of genetic transmission is unknown, the maximum of the LOD scores obtained using several genetic parameter values is reported.
Yoo YJ, Mendell NR.
europepmc   +6 more sources

Ordered subset linkage analysis supports a susceptibility locus for age-related macular degeneration on chromosome 16p12 [PDF]

BMC Genetics, 2004
Background Age-related macular degeneration (AMD) is a complex disorder that is responsible for the majority of central vision loss in older adults living in developed countries. Phenotypic and genetic heterogeneity complicate the analysis of genome-wide
Weeks Daniel E, Gilbert John R, De La Paz Monica A, Hauser Elizabeth R, Agarwal Anita, Postel Eric A, Scott William K, Schmidt Silke, Gorin Michael B, Haines Jonathan L, Pericak-Vance Margaret A   +10 more
doaj   +5 more sources

Monitoring of BNP cardiac biomarker with major emphasis on biosensing methods: A review

Sensors International, 2021
Heart failure (HF) is a prominent disease becomes a crucial cause of morbidity and mortality. It is a severe condition in which the heart is incapable to supply adequate blood to the patient's body. More than 26 million people globally exist with HF.
Twinkle Dahiya, Sarita Yadav, Neelam Yadav, Avantika Mann, Minakshi Sharma, J.S. Rana   +5 more
doaj   +1 more source

Linkage replication for chromosomal region 13q32 in schizophrenia: evidence from a Brazilian pilot study on early onset schizophrenia families. [PDF]

PLoS ONE, 2012
We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN® software.
Ary Gadelha, Vanessa Kiyomi Ota, Jose Paya Cano, Maria Isabel Melaragno, Marilia A C Smith, Jair de Jesus Mari, Rodrigo A Bressan, Sintia Iole Belangero, Gerome Breen   +8 more
doaj   +1 more source

Identification of a Locus on the X Chromosome Linked to Familial Membranous Nephropathy

Kidney International Reports, 2021
Introduction: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults and is a leading cause of end-stage renal disease due to glomerulonephritis.
Mallory L. Downie, Sanjana Gupta, Mehmet C. Tekman, Chris Cheshire, Steven Arora, Christoph Licht, Lisa A. Robinson, Marina Munoz, Alvaro Madrid Aris, Ibrahim Al Attrach, Paul E. Brenchley, Daniel P. Gale, Horia Stanescu, Detlef Bockenhauer, Robert Kleta   +14 more
doaj   +1 more source

Differences in Odor Identification in Early-Onset and Late-Onset Depression

Brain Sciences, 2022
(1) Background: Odor identification (OI) dysfunction is a potential predictor of developing dementia in late life depression (LLD). However, it is not clear whether patients with early onset depression (EOD) and late onset depression (LOD) may exhibit ...
Meiling Liu, Ben Chen, Xiaomei Zhong, Min Zhang, Qiang Wang, Huarong Zhou, Zhangying Wu, Le Hou, Qi Peng, Si Zhang, Minfeng Yang, Gaohong Lin, Yuping Ning   +12 more
doaj   +1 more source

High-density genomewide linkage analysis of exceptional human longevity identifies multiple novel loci. [PDF]

PLoS ONE, 2010
Human lifespan is approximately 25% heritable, and genetic factors may be particularly important for achieving exceptional longevity. Accordingly, siblings of centenarians have a dramatically higher probability of reaching extreme old age than the ...
Steven E Boyden, Louis M Kunkel
doaj   +1 more source

QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the hypertension genetic epidemiology network study

BMC Medical Genetics, 2008
Background In a previous study of the Hypertension Genetic Epidemiology Network (HyperGEN) we have shown that metabolic syndrome (MetS) risk factors were moderately and significantly associated with echocardiographic (ECHO) left ventricular (LV ...
de Simone Giovanni, Devereux Richard B, Lewis Cora E, North Kari E, Hunt Steven C, Tang Weihong, Huang Pinchia, Kraja Aldi T, Arnett Donna K, Rice Treva, Rao DC   +10 more
doaj   +1 more source

A genome-wide search for risk genes using homozygosity mapping and microarrays with 1,494 single-nucleotide polymorphisms in 22 eastern Cuban families with bipolar disorder [PDF]

, 2005
Homozygosity mapping is a very powerful method for finding rare recessive disease genes in monogenic disorders and may also be useful for locating risk genes in complex disorders, late onset disorders where parents often are not available, and for rare ...
American Psychiatric Association, Baron, Bennett, Bull, Bull, Curtis, Dick, Ewald, Ewald, Houwen, Kruglyak, Kruglyak, Lander, Miano, Modin, Primdahl, Segurado, van Duijn, Wang, Wing, World Health Organization, Wright   +21 more
core   +1 more source

Genetic loci linked to Type 1 Diabetes and Multiple Sclerosis families in Sardinia

BMC Medical Genetics, 2008
Background The Mediterranean island of Sardinia has a strikingly high incidence of the autoimmune disorders Type 1 Diabetes (T1D) and Multiple Sclerosis (MS).
Frongia Paola, Maioli Mario, Pacifico Adolfo, Pala Gavino, Nucaro Annalisa, Lampis Rosanna, Contu Daniela, Corongiu Daniela, Secci Maria, Rolesu Marcella, Cuccu Stefania, Tranquilli Stefania, Mancosu Cristina, Lai Marina, Melis Maria, Schirru Lucia, Fadda Elisabetta, Solla Elisabetta, Costa Gianna, Orrù Valeria, Motzo Costantino, Moi Loredana, Murru Daniela, Zoledziewska Magdalena, Deidda Elisabetta, Murru Raffaele, Zavattari Patrizia, Pitzalis Maristella, Chessa Margherita, Ricciardi Rossella, Lostia Stanislao, Marinaro Anna, Milia Anna, Landis Novella, Zedda Maria, Whalen Michael B, Santoni Federico, Marrosu Maria, Devoto Marcella, Cucca Francesco   +39 more
doaj   +1 more source