Results 11 to 20 of about 72,586 (301)

Patients with Acute Myeloid Leukemia Admitted to Intensive Care Units: Outcome Analysis and Risk Prediction. [PDF]

PLoS ONE, 2016
BACKGROUND:This retrospective, multicenter study aimed to reveal risk predictors for mortality in the intensive care unit (ICU) as well as survival after ICU discharge in patients with acute myeloid leukemia (AML) requiring treatment in the ICU.
Michele Pohlen, Nils H Thoennissen, Jan Braess, Johannes Thudium, Christoph Schmid, Matthias Kochanek, Karl-Anton Kreuzer, Pia Lebiedz, Dennis Görlich, Hans U Gerth, Christian Rohde, Torsten Kessler, Carsten Müller-Tidow, Matthias Stelljes, Carsten Hullermann, Thomas Büchner, Günter Schlimok, Michael Hallek, Johannes Waltenberger, Wolfgang Hiddemann, Wolfgang E Berdel, Bernhard Heilmeier, Utz Krug   +22 more
doaj   +1 more source

A novel locus for autosomal recessive primary microcephaly (MCPH6) maps to 13q12.2 [PDF]

, 2003
Key points: • Autosomal recessive primary microcephaly (MCPH) is a genetic disorder in which an affected subject is born with a head circumference >3 SD below the expected mean and is mentally retarded.
Costa, S.M.R., Hampshire, D.J., Leal, G.F., Roberts, E., Silva, E.O., Woods, C.G.   +5 more
core   +2 more sources

Parameter Estimation and Quantitative Parametric Linkage Analysis with GENEHUNTER-QMOD [PDF]

, 2012
Objective: We present a parametric method for linkage analysis of quantitative phenotypes. The method provides a test for linkage as well as an estimate of different phenotype parameters.
Abecasis GR, Almasy L, Birgin EG, Birgin EG, Chen WM, Dietter J, Dietter J, Dudbridge F, Elston RC, Franke D, Gudbjartsson DF, Haseman JK, Holmans P, Kleensang A, Knapp M, Kong A, Konstantin Strauch, Kruglyak L, Kurz T, Kurz T, Lander ES, Lathrop GM, Mattheisen M, Morris N, Pratt SC, Strauch K, Strauch K, Thomas Künzel, Ziegler A   +28 more
core   +1 more source

Computing expectation values for RNA motifs using discrete convolutions

BMC Bioinformatics, 2005
Background Computational biologists use Expectation values (E-values) to estimate the number of solutions that can be expected by chance during a database scan.
Fontaine Jean-Fred, Legendre Matthieu, Lambert André, Gautheret Daniel   +3 more
doaj   +1 more source

Different Modular Organization Between Early Onset and Late Onset Depression: A Study Base on Granger Causality Analysis

Frontiers in Aging Neuroscience, 2021
Background: Modular organization reflects the activity patterns of our brain. Different disease states may lead to different activity patterns and clinical features.
Naikeng Mai, Yujie Wu, Xiaomei Zhong, Ben Chen, Min Zhang, Qi Peng, Yuping Ning, Yuping Ning, Yuping Ning   +8 more
doaj   +1 more source

Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program

BMC Medical Genetics, 2006
Background Elevated resting heart rate has been shown in multiple studies to be a strong predictor of cardiovascular disease. Previous family studies have shown a significant heritable component to heart rate with several groups conducting genomic ...
Ellison R Curtis, Hunt Steven C, Wilk Jemma B, Laramie Jason M, Chakravarti Aravinda, Boerwinkle Eric, Myers Richard H   +6 more
doaj   +1 more source

A genome-wide linkage scan for distinct subsets of schizophrenia characterized by age at onset and neurocognitive deficits. [PDF]

PLoS ONE, 2011
As schizophrenia is genetically and phenotypically heterogeneous, targeting genetically informative phenotypes may help identify greater linkage signals.
Yin-Ju Lien, Po-Chang Hsiao, Chih-Min Liu, Stephen V Faraone, Ming T Tsuang, Hai-Gwo Hwu, Wei J Chen   +6 more
doaj   +1 more source

Linkage to chromosome 11p12 in two Maltese families with a highly penetrant form of osteoporosis [PDF]

, 2007
Osteoporosis is a metabolic bone disease with a strong genetic component. Family-based linkage studies were performed by a number of investigators to try to identify loci that might contain genes responsible for an increased susceptibility to ...
Brincat, Mark P., Galea, Raymond P., Vidal, Christopher, Xuereb-Anastasi, Angela   +3 more
core   +1 more source

Accuracy of short sequence repeats on single‑parent parentage identification in Chinese shrimp Fenneropenaeus chinensis

Aquatic Biology, 2014
Based on the parentage identification results using 4 polymorphic short sequence repeats (SSRs) with both parents known, we assessed the accuracy of parentage identification for a single known parent using the same 4 SSRs and 4 other additional SSRs for ...
K Zhang, W Wang, J Kong, K Luo, X Jin
doaj   +1 more source

A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains. [PDF]

, 2015
The genetic variants underlying complex traits are often elusive even in powerful model organisms such as Caenorhabditis elegans with controlled genetic backgrounds and environmental conditions.
Andersen, Erik C, Bloom, Joshua S, Crissman, Jonathan R, Gerke, Justin P, Ghosh, Rajarshi, Kruglyak, Leonid, Seidel, Hannah S, Shimko, Tyler C   +7 more
core   +2 more sources