Results 21 to 30 of about 1,870,567 (303)

Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease

Lipids in Health and Disease, 2008
Background The APOA1-C3-A5 gene cluster plays an important role in the regulation of lipids. Asian Indians have an increased tendency for abnormal lipid levels and high risk of Coronary Artery Disease (CAD).
Hebbagodi Sridhara, John Shibu, Khadrinarasimhiah Natesha B, Rao Veena S, Perumal Ganapathy, Shanker Jayashree, Mukherjee Manjari, Kakkar Vijay V   +7 more
doaj   +1 more source

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

BMC Medical Genomics, 2018
Background Electrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk. We combined linkage and association analyses to discover novel rare genetic variants involved in three such measures and two ...
Claudia Tamar Silva, Irina V. Zorkoltseva, Maartje N. Niemeijer, Marten E. van den Berg, Najaf Amin, Ayşe Demirkan, Elisa van Leeuwen, Adriana I. Iglesias, Laura B. Piñeros-Hernández, Carlos M. Restrepo, Jan A. Kors, Anatoly V. Kirichenko, Rob Willemsen, Ben A. Oostra, Bruno H. Stricker, André G. Uitterlinden, Tatiana I. Axenovich, Cornelia M. van Duijn, Aaron Isaacs   +18 more
doaj   +1 more source

A genome scan for serum triglyceride in obese nuclear families

Journal of Lipid Research, 2005
Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. We carried out a genome scan for serum TG in 320 nuclear families segregating extreme obesity and normal ...
Wei-Dong Li, Chuanhui Dong, Ding Li, Cathleen Garrigan, R. Arlen Price   +4 more
doaj   +1 more source

Manic Depressive Illness and Tyrosine Hydroxylase Gene: Linkage Heterogeneity and Association

Neurobiology of Disease, 1997
Several studies have implicated the tyrosine hydroxylase (TH) locus within the 11p15 region in susceptibility to manic depressive illness (MDI). This possibility was further investigated by both parametric (lod score) and nonparametric (affected-pedigree-
Alain Malafosse, Marion Leboyer, Thierry d'Amato, Stephane Amadéo, Mocrane Abbar, Dominique Campion, Olivier Canseil, Didier Castelnau, Francis Gheysen, Bernard Granger, Birgitta Henrikson, Marie-France Poirier, Olivier Sabaté, Danielle Samolyk, Josué Feingold, Jacques Mallet   +15 more
doaj   +1 more source

The genetics of reading disability in an often excluded sample: novel loci suggested for reading disability in Rolandic epilepsy.

PLoS ONE, 2012
BackgroundReading disability (RD) is a common neurodevelopmental disorder with genetic basis established in families segregating "pure" dyslexia. RD commonly occurs in neurodevelopmental disorders including Rolandic Epilepsy (RE), a complex genetic ...
Lisa J Strug, Laura Addis, Theodore Chiang, Zeynep Baskurt, Weili Li, Tara Clarke, Huntley Hardison, Steven L Kugler, David E Mandelbaum, Edward J Novotny, Steven M Wolf, Deb K Pal   +11 more
doaj   +1 more source

A comparison of different linkage statistics in small to moderate sized pedigrees with complex diseases

BMC Research Notes, 2012
Background In the last years GWA studies have successfully identified common SNPs associated with complex diseases. However, most of the variants found this way account for only a small portion of the trait variance.
Flaquer Antònia, Strauch Konstantin
doaj   +1 more source

A combined linkage and exome sequencing analysis for electrocardiogram parameters in the Erasmus Rucphen Family study

Frontiers in Genetics, 2016
Electrocardiogram (ECG) measurements play a key role in the diagnosis and prediction of cardiac arrhythmias and sudden cardiac death. ECG parameters, such as the PR, QRS, and QT intervals, are known to be heritable and genome-wide association studies ...
Claudia Tamar Silva, Claudia Tamar Silva, Claudia Tamar Silva, Irina Zorkoltseva, Najaf Amin, Ayse Demirkan, Ayse Demirkan, Elisabeth Maria van Leeuwen, Jan Kors, Marten van den Berg, Bruno Stricker, Bruno Stricker, Bruno Stricker, André Uitterlinden, Anatoly Kirichenko, Jacqueline C.M. Witteman, Rob Willemsen, Ben Oostra, Ben Oostra, Tatiana Axenovich, Cornelia Marja Van Duijn, Cornelia Marja Van Duijn, Aaron Isaacs, Aaron Isaacs   +23 more
doaj   +1 more source

Interval Mapping Using Nonparametric Accelerated Failure Time Cure Model [PDF]

Journal of Statistical Theory and Applications (JSTA), 2013
Many important problems in evolutionary biology begin with observations of phenotypic variation. Suppose time to an event-data are used to map quantitative trait loci (QTL) and underlying population is a mixture of susceptible and non-susceptible ...
Devrim Bilgili, Nader Ebrahimi
doaj   +1 more source

Maximum LOD scores at DYX loci in the original dataset ‘r’ indicates maximization of lod score under recessive model, ‘d’ under dominant model.

, 2012
Maximum LOD scores at DYX loci in the original dataset ‘r’ indicates maximization of lod score under recessive model, ‘d’ under dominant model.
Zeynep Baskurt (151147), Lisa J. Strug (151135), Tara Clarke (151154), Steven L. Kugler (151160), Deb K. Pal (151175), Laura Addis (151139), Weili Li (151151), Steven M. Wolf (151171), David E. Mandelbaum (151163), Edward J. Novotny (151167), Huntley Hardison (151157), Theodore Chiang (151143)   +11 more
core   +1 more source

Allele frequency misspecification: effect on power and Type I error of model-dependent linkage analysis of quantitative traits under random ascertainment

BMC Genetics, 2006
Background Studies of model-based linkage analysis show that trait or marker model misspecification leads to decreasing power or increasing Type I error rate.
Wilson Alexander F, Atwood Larry D, Sorant Alexa JM, Mandal Diptasri M, Bailey-Wilson Joan E   +4 more
doaj   +1 more source