Results 21 to 30 of about 33,686 (303)

A genome-wide linkage scan for distinct subsets of schizophrenia characterized by age at onset and neurocognitive deficits. [PDF]

PLoS ONE, 2011
As schizophrenia is genetically and phenotypically heterogeneous, targeting genetically informative phenotypes may help identify greater linkage signals.
Yin-Ju Lien, Po-Chang Hsiao, Chih-Min Liu, Stephen V Faraone, Ming T Tsuang, Hai-Gwo Hwu, Wei J Chen   +6 more
doaj   +1 more source

Accuracy of short sequence repeats on single‑parent parentage identification in Chinese shrimp Fenneropenaeus chinensis

Aquatic Biology, 2014
Based on the parentage identification results using 4 polymorphic short sequence repeats (SSRs) with both parents known, we assessed the accuracy of parentage identification for a single known parent using the same 4 SSRs and 4 other additional SSRs for ...
K Zhang, W Wang, J Kong, K Luo, X Jin
doaj   +1 more source

Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease

Lipids in Health and Disease, 2008
Background The APOA1-C3-A5 gene cluster plays an important role in the regulation of lipids. Asian Indians have an increased tendency for abnormal lipid levels and high risk of Coronary Artery Disease (CAD).
Hebbagodi Sridhara, John Shibu, Khadrinarasimhiah Natesha B, Rao Veena S, Perumal Ganapathy, Shanker Jayashree, Mukherjee Manjari, Kakkar Vijay V   +7 more
doaj   +1 more source

A genome scan for serum triglyceride in obese nuclear families

Journal of Lipid Research, 2005
Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. We carried out a genome scan for serum TG in 320 nuclear families segregating extreme obesity and normal ...
Wei-Dong Li, Chuanhui Dong, Ding Li, Cathleen Garrigan, R. Arlen Price   +4 more
doaj   +1 more source

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

BMC Medical Genomics, 2018
Background Electrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk. We combined linkage and association analyses to discover novel rare genetic variants involved in three such measures and two ...
Claudia Tamar Silva, Irina V. Zorkoltseva, Maartje N. Niemeijer, Marten E. van den Berg, Najaf Amin, Ayşe Demirkan, Elisa van Leeuwen, Adriana I. Iglesias, Laura B. Piñeros-Hernández, Carlos M. Restrepo, Jan A. Kors, Anatoly V. Kirichenko, Rob Willemsen, Ben A. Oostra, Bruno H. Stricker, André G. Uitterlinden, Tatiana I. Axenovich, Cornelia M. van Duijn, Aaron Isaacs   +18 more
doaj   +1 more source

Manic Depressive Illness and Tyrosine Hydroxylase Gene: Linkage Heterogeneity and Association

Neurobiology of Disease, 1997
Several studies have implicated the tyrosine hydroxylase (TH) locus within the 11p15 region in susceptibility to manic depressive illness (MDI). This possibility was further investigated by both parametric (lod score) and nonparametric (affected-pedigree-
Alain Malafosse, Marion Leboyer, Thierry d'Amato, Stephane Amadéo, Mocrane Abbar, Dominique Campion, Olivier Canseil, Didier Castelnau, Francis Gheysen, Bernard Granger, Birgitta Henrikson, Marie-France Poirier, Olivier Sabaté, Danielle Samolyk, Josué Feingold, Jacques Mallet   +15 more
doaj   +1 more source

The genetics of reading disability in an often excluded sample: novel loci suggested for reading disability in Rolandic epilepsy.

PLoS ONE, 2012
BackgroundReading disability (RD) is a common neurodevelopmental disorder with genetic basis established in families segregating "pure" dyslexia. RD commonly occurs in neurodevelopmental disorders including Rolandic Epilepsy (RE), a complex genetic ...
Lisa J Strug, Laura Addis, Theodore Chiang, Zeynep Baskurt, Weili Li, Tara Clarke, Huntley Hardison, Steven L Kugler, David E Mandelbaum, Edward J Novotny, Steven M Wolf, Deb K Pal   +11 more
doaj   +1 more source

Allele frequency misspecification: effect on power and Type I error of model-dependent linkage analysis of quantitative traits under random ascertainment

BMC Genetics, 2006
Background Studies of model-based linkage analysis show that trait or marker model misspecification leads to decreasing power or increasing Type I error rate.
Wilson Alexander F, Atwood Larry D, Sorant Alexa JM, Mandal Diptasri M, Bailey-Wilson Joan E   +4 more
doaj   +1 more source

Combinatorial Conflicting Homozygosity (CCH) analysis enables the rapid identification of shared genomic regions in the presence of multiple phenocopies.

, 2015
The ability to identify regions of the genome inherited with a dominant trait in one or more families has become increasingly valuable with the wide availability of high throughput sequencing technology.
Neild, GH, Connor, TM, Levine, AP, Maxwell, PH, Gale, DP, Oygar, DD, Segal, AW   +6 more
core   +1 more source

LOD score curves on chromosome 13.

, 2014
(A) A significant QTL for glomerular index was detected on chromosome 13. The approximate 95% confidential intervals: 0–31.5 cM. (B) Glomerular index at the peak LOD score (D13Mit60).
Ken-ichi Nagasaki (5130728), Takashi Agui (185979), Daisuke Torigoe (185972), Tomohiro Nishino (589345), Hayato Sasaki (589344), Nobuya Sasaki (185961), Hiroshi Kitamura (269785)   +6 more
core   +1 more source