Results 21 to 30 of about 72,586 (301)

Replication of linkage at chromosome 20p13 and identification of suggestive sex-differential risk loci for autism spectrum disorder. [PDF]

, 2014
BackgroundAutism spectrum disorders (ASDs) are male-biased and genetically heterogeneous. While sequencing of sporadic cases has identified de novo risk variants, the heritable genetic contribution and mechanisms driving the male bias are less understood.
Cantor, Rita M, Geschwind, Daniel H, Lowe, Jennifer K, Luo, Rui, Werling, Donna M, Werling, Donna M   +5 more
core   +2 more sources

Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease

Lipids in Health and Disease, 2008
Background The APOA1-C3-A5 gene cluster plays an important role in the regulation of lipids. Asian Indians have an increased tendency for abnormal lipid levels and high risk of Coronary Artery Disease (CAD).
Hebbagodi Sridhara, John Shibu, Khadrinarasimhiah Natesha B, Rao Veena S, Perumal Ganapathy, Shanker Jayashree, Mukherjee Manjari, Kakkar Vijay V   +7 more
doaj   +1 more source

A genome scan for serum triglyceride in obese nuclear families

Journal of Lipid Research, 2005
Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. We carried out a genome scan for serum TG in 320 nuclear families segregating extreme obesity and normal ...
Wei-Dong Li, Chuanhui Dong, Ding Li, Cathleen Garrigan, R. Arlen Price   +4 more
doaj   +1 more source

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

BMC Medical Genomics, 2018
Background Electrocardiographic measures of left ventricular hypertrophy (LVH) are used as predictors of cardiovascular risk. We combined linkage and association analyses to discover novel rare genetic variants involved in three such measures and two ...
Claudia Tamar Silva, Irina V. Zorkoltseva, Maartje N. Niemeijer, Marten E. van den Berg, Najaf Amin, Ayşe Demirkan, Elisa van Leeuwen, Adriana I. Iglesias, Laura B. Piñeros-Hernández, Carlos M. Restrepo, Jan A. Kors, Anatoly V. Kirichenko, Rob Willemsen, Ben A. Oostra, Bruno H. Stricker, André G. Uitterlinden, Tatiana I. Axenovich, Cornelia M. van Duijn, Aaron Isaacs   +18 more
doaj   +1 more source

Rejoinder: Quantifying the Fraction of Missing Information for Hypothesis Testing in Statistical and Genetic Studies [PDF]

, 2011
Rejoinder to "Quantifying the Fraction of Missing Information for Hypothesis Testing in Statistical and Genetic Studies" [arXiv:1102.2774]Comment: Published in at http://dx.doi.org/10.1214/08-STS244REJ the Statistical Science (http://www.imstat.org/sts/
Kong, Augustine, Meng, Xiao-Li, Nicolae, Dan L.   +2 more
core   +2 more sources

Manic Depressive Illness and Tyrosine Hydroxylase Gene: Linkage Heterogeneity and Association

Neurobiology of Disease, 1997
Several studies have implicated the tyrosine hydroxylase (TH) locus within the 11p15 region in susceptibility to manic depressive illness (MDI). This possibility was further investigated by both parametric (lod score) and nonparametric (affected-pedigree-
Alain Malafosse, Marion Leboyer, Thierry d'Amato, Stephane Amadéo, Mocrane Abbar, Dominique Campion, Olivier Canseil, Didier Castelnau, Francis Gheysen, Bernard Granger, Birgitta Henrikson, Marie-France Poirier, Olivier Sabaté, Danielle Samolyk, Josué Feingold, Jacques Mallet   +15 more
doaj   +1 more source

Causal graphical models in systems genetics: A unified framework for joint inference of causal network and genetic architecture for correlated phenotypes [PDF]

, 2009
Causal inference approaches in systems genetics exploit quantitative trait loci (QTL) genotypes to infer causal relationships among phenotypes. The genetic architecture of each phenotype may be complex, and poorly estimated genetic architectures may ...
Attie, Alan D., Keller, Mark P., Neto, Elias Chaibub, Yandell, Brian S.   +3 more
core   +3 more sources

The genetics of reading disability in an often excluded sample: novel loci suggested for reading disability in Rolandic epilepsy.

PLoS ONE, 2012
BackgroundReading disability (RD) is a common neurodevelopmental disorder with genetic basis established in families segregating "pure" dyslexia. RD commonly occurs in neurodevelopmental disorders including Rolandic Epilepsy (RE), a complex genetic ...
Lisa J Strug, Laura Addis, Theodore Chiang, Zeynep Baskurt, Weili Li, Tara Clarke, Huntley Hardison, Steven L Kugler, David E Mandelbaum, Edward J Novotny, Steven M Wolf, Deb K Pal   +11 more
doaj   +1 more source

Distribution of model‐based multipoint heterogeneity lod scores [PDF]

Genetic Epidemiology, 2010
AbstractThe distribution of two‐point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ2 approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating th e distribution of the multipoint HLOD despite its wide application.
Chao, Xing, Nathan, Morris, Guan, Xing
openaire   +2 more sources

Allele frequency misspecification: effect on power and Type I error of model-dependent linkage analysis of quantitative traits under random ascertainment

BMC Genetics, 2006
Background Studies of model-based linkage analysis show that trait or marker model misspecification leads to decreasing power or increasing Type I error rate.
Wilson Alexander F, Atwood Larry D, Sorant Alexa JM, Mandal Diptasri M, Bailey-Wilson Joan E   +4 more
doaj   +1 more source