Results 31 to 40 of about 33,686 (303)

A comparison of different linkage statistics in small to moderate sized pedigrees with complex diseases

open access: yesBMC Research Notes, 2012
Background In the last years GWA studies have successfully identified common SNPs associated with complex diseases. However, most of the variants found this way account for only a small portion of the trait variance.
Flaquer Antònia, Strauch Konstantin
doaj   +1 more source

Interval Mapping Using Nonparametric Accelerated Failure Time Cure Model [PDF]

open access: yesJournal of Statistical Theory and Applications (JSTA), 2013
Many important problems in evolutionary biology begin with observations of phenotypic variation. Suppose time to an event-data are used to map quantitative trait loci (QTL) and underlying population is a mixture of susceptible and non-susceptible ...
Devrim Bilgili, Nader Ebrahimi
doaj   +1 more source

Lod score values varying the D' value between marker 4 and disease locus A.

open access: yes, 2014
Unstratified lod score is represented by solid line and stratified lod score by dashed line. Horizontal dotted line identifies the threshold for significant evidence of linkage.
David A. Greenberg (319010)   +1 more
core   +1 more source

Genetic linkage mapping and QTL identification for salinity tolerance in Indian mustard (Brassica juncea L. Czern and Coss.) using SSR markers

open access: yesOil Crop Science, 2023
Soil salinity is one of the major environmental constraints that limits crop yield and nearly 7% of the total area worldwide is affected by salinity. Salinity-induced oxidative stress causes membrane damage during germination and seedling growth.
Rekha Patel   +4 more
doaj   +1 more source

A combined linkage and exome sequencing analysis for electrocardiogram parameters in the Erasmus Rucphen Family study

open access: yesFrontiers in Genetics, 2016
Electrocardiogram (ECG) measurements play a key role in the diagnosis and prediction of cardiac arrhythmias and sudden cardiac death. ECG parameters, such as the PR, QRS, and QT intervals, are known to be heritable and genome-wide association studies ...
Claudia Tamar Silva   +23 more
doaj   +1 more source

Variation in LOD score distribution by position on Chr 1.

open access: yes, 2013
Distribution of 95th percentile LOD scores by marker for 10,000 GRAIP permutations of coat color and body weight QTL mapping in the AIL population. Note that the maximum and minimum values of the 95th percentile on this chromosome alone are separated by ...
Jeremy L. Peirce (80213)   +7 more
core   +1 more source

Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Québec Family Study

open access: yesJournal of Lipid Research, 2004
A genome-wide linkage study was performed to identify chromosomal regions harboring genes influencing lipid and lipoprotein levels. Linkage analyses were conducted for four quantitative lipoprotein/lipid traits, i.e., total cholesterol, triglyceride, HDL-
Y. Bossé   +7 more
doaj   +1 more source

LOD score distributions from CERVUS analyses of parentage in three-toed woodpeckers.

open access: yes, 2013
(a) LOD score for the candidate males that have been unequivocally assigned as fathers (▪) and for candidate males that were the second most likely candidate excluded (□) (N = 80); (b) LOD score for the candidate females that have been unequivocally ...
Markus Piha (369243)   +4 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Prognostic values of SOFA score, qSOFA score, and LODS score for patients with sepsis

open access: yesAnnals of Palliative Medicine, 2020
Sepsis continues to carry a high rate of mortality, which makes effective and simple evaluation methods for predicting the prognosis of septic patients especially important. In this study, we retrospectively analyzed the relationships between three scoring systems including Sequential Organ Failure Assessment (SOFA) score, Quick SOFA (qSOFA) score, and
Yonglin, Li   +6 more
openaire   +2 more sources

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